标题
Primary cilia and graded Sonic Hedgehog signaling
作者
关键词
-
出版物
Wiley Interdisciplinary Reviews-Developmental Biology
Volume 1, Issue 5, Pages 753-772
出版商
Wiley
发表日期
2012-04-05
DOI
10.1002/wdev.43
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus
- (2011) Helen J Blair et al. BMC BIOLOGY
- A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development
- (2011) Ellen J. Ezratty et al. CELL
- Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways
- (2011) Liyun Sang et al. CELL
- Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation
- (2011) Luisa Izzi et al. DEVELOPMENTAL CELL
- Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function
- (2011) Benjamin L. Allen et al. DEVELOPMENTAL CELL
- Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia
- (2011) J. B. Wallingford et al. GENES & DEVELOPMENT
- An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia
- (2011) Suzanne Rix et al. HUMAN MOLECULAR GENETICS
- Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
- (2011) Yan Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
- (2011) Corey L. Williams et al. JOURNAL OF CELL BIOLOGY
- Subcellular spatial regulation of canonical Wnt signalling at the primary cilium
- (2011) Madeline A. Lancaster et al. NATURE CELL BIOLOGY
- Complex interactions between genes controlling trafficking in primary cilia
- (2011) Polloneal Jymmiel R Ocbina et al. NATURE GENETICS
- Mechanisms and functions of Hedgehog signalling across the metazoa
- (2011) Philip W. Ingham et al. NATURE REVIEWS GENETICS
- Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components
- (2011) J. Qin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
- (2011) Yongbin Chen et al. PLOS BIOLOGY
- Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?
- (2010) Maxence V. Nachury et al. Annual Review of Cell and Developmental Biology
- Transcriptional control of genes involved in ciliogenesis: a first step in making cilia
- (2010) Joëlle Thomas et al. BIOLOGY OF THE CELL
- Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
- (2010) Hyejeong Kim et al. BMC BIOLOGY
- The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia
- (2010) Hua Jin et al. CELL
- Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts
- (2010) Linda Schneider et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
- (2010) C. Wang et al. DEVELOPMENT
- Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling
- (2010) C. Cruz et al. DEVELOPMENT
- PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals
- (2010) Huiqing Zeng et al. DEVELOPMENTAL BIOLOGY
- Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry
- (2010) Doris Kinzel et al. DEVELOPMENTAL CELL
- MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling
- (2010) Marina Bershteyn et al. DEVELOPMENTAL CELL
- Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction
- (2010) Hyuk Wan Ko et al. DEVELOPMENTAL CELL
- The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
- (2010) E. W. Humke et al. GENES & DEVELOPMENT
- TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
- (2010) S. Mukhopadhyay et al. GENES & DEVELOPMENT
- A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
- (2010) Hanna Tukachinsky et al. JOURNAL OF CELL BIOLOGY
- CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content
- (2010) Branch Craige et al. JOURNAL OF CELL BIOLOGY
- The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia
- (2010) A. Molla-Herman et al. JOURNAL OF CELL SCIENCE
- The perennial organelle: assembly and disassembly of the primary cilium
- (2010) E. S. Seeley et al. JOURNAL OF CELL SCIENCE
- Differential role of Rab proteins in ciliary trafficking: Rab23 regulates Smoothened levels
- (2010) C. Boehlke et al. JOURNAL OF CELL SCIENCE
- Somatostatin Signaling in Neuronal Cilia Is Criticalfor Object Recognition Memory
- (2010) E. B. Einstein et al. JOURNAL OF NEUROSCIENCE
- Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation
- (2010) X. Wen et al. MOLECULAR AND CELLULAR BIOLOGY
- Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
- (2010) Gianluca Canettieri et al. NATURE CELL BIOLOGY
- Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP
- (2010) John F. Dishinger et al. NATURE CELL BIOLOGY
- Primary cilia regulate mTORC1 activity and cell size through Lkb1
- (2010) Christopher Boehlke et al. NATURE CELL BIOLOGY
- The primary cilium: a signalling centre during vertebrate development
- (2010) Sarah C. Goetz et al. NATURE REVIEWS GENETICS
- SUMOylation by Pias1 Regulates the Activity of the Hedgehog Dependent Gli Transcription Factors
- (2010) Barny Cox et al. PLoS One
- A Septin Diffusion Barrier at the Base of the Primary Cilium Maintains Ciliary Membrane Protein Distribution
- (2010) Q. Hu et al. SCIENCE
- Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog
- (2010) Eric Dessaud et al. PLOS BIOLOGY
- Mutations in STIL, Encoding a Pericentriolar and Centrosomal Protein, Cause Primary Microcephaly
- (2009) Arun Kumar et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Centrioles, Centrosomes, and Cilia in Health and Disease
- (2009) Erich A. Nigg et al. CELL
- The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development
- (2009) Setsu Endoh-Yamagami et al. CURRENT BIOLOGY
- The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation
- (2009) Y. Yin et al. DEVELOPMENT
- Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
- (2009) P. Huang et al. DEVELOPMENT
- Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
- (2009) Jinping Jia et al. DEVELOPMENTAL BIOLOGY
- Zebrafishift57,ift88, andift172intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling
- (2009) Shannon C. Lunt et al. DEVELOPMENTAL DYNAMICS
- Planar cell polarity effector geneFuzzyregulates cilia formation and Hedgehog signal transduction in mouse
- (2009) Westley Heydeck et al. DEVELOPMENTAL DYNAMICS
- Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
- (2009) M.-H. Chen et al. GENES & DEVELOPMENT
- Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling
- (2009) Ryan X. Norman et al. HUMAN MOLECULAR GENETICS
- Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
- (2009) Victoria L. Patterson et al. HUMAN MOLECULAR GENETICS
- A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling
- (2009) Scott D. Weatherbee et al. HUMAN MOLECULAR GENETICS
- The Na+/H+exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium
- (2009) Linda Schneider et al. JOURNAL OF CELL BIOLOGY
- Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
- (2009) Ljiljana Milenkovic et al. JOURNAL OF CELL BIOLOGY
- Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base
- (2009) M. Barzi et al. JOURNAL OF CELL SCIENCE
- FGF signalling during embryo development regulates cilia length in diverse epithelia
- (2009) Judith M. Neugebauer et al. NATURE
- The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development
- (2009) Ryan S. Gray et al. NATURE CELL BIOLOGY
- Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
- (2009) K. F. Liem et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
- (2009) J. M. Hyman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
- (2009) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
- (2009) Yu Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Ciliogenesis
- (2009) A. M. Ashique et al. Science Signaling
- The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling
- (2009) H. O.-L. Cheung et al. Science Signaling
- Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia
- (2009) Michael A. Silverman et al. TRENDS IN CELL BIOLOGY
- Left-Right Determination: Involvement of Molecular Motor KIF3, Cilia, and Nodal Flow
- (2009) N. Hirokawa et al. Cold Spring Harbor Perspectives in Biology
- CC2D2A Is Mutated in Joubert Syndrome and Interacts with the Ciliopathy-Associated Basal Body Protein CEP290
- (2008) Nicholas T. Gorden et al. AMERICAN JOURNAL OF HUMAN GENETICS
- C2cd3 is required for cilia formation and Hedgehog signaling in mouse
- (2008) A. N. Hoover et al. DEVELOPMENT
- Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
- (2008) C. E. Chamberlain et al. DEVELOPMENT
- Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
- (2008) E. Dessaud et al. DEVELOPMENT
- FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism
- (2008) Ahryon Cho et al. DEVELOPMENTAL BIOLOGY
- Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
- (2008) Salvatore Cortellino et al. DEVELOPMENTAL BIOLOGY
- Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning
- (2008) Marwan K. Tayeh et al. HUMAN MOLECULAR GENETICS
- Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase
- (2008) Melanie Philipp et al. MOLECULAR BIOLOGY OF THE CELL
- Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors
- (2008) Nicolas F. Berbari et al. MOLECULAR BIOLOGY OF THE CELL
- Foxj1 transcription factors are master regulators of the motile ciliogenic program
- (2008) Xianwen Yu et al. NATURE GENETICS
- Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells
- (2008) Tae Joo Park et al. NATURE GENETICS
- THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
- (2008) Pamela V Tran et al. NATURE GENETICS
- The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos
- (2008) Jennifer L Stubbs et al. NATURE GENETICS
- Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
- (2008) Young-Goo Han et al. NATURE NEUROSCIENCE
- Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome
- (2008) J. L. Tobin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Arrestin-Mediated Localization of Smoothened to the Primary Cilium
- (2008) J. J. Kovacs et al. SCIENCE
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