A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives
出版年份 2016 全文链接
标题
A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives
作者
关键词
-
出版物
Stem Cells International
Volume 2016, Issue -, Pages 1-15
出版商
Hindawi Limited
发表日期
2016-06-29
DOI
10.1155/2016/7290686
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Modulation of MAPK signalling by immobilized adhesive peptides: Effect on stem cell response to BMP-9-derived peptides
- (2016) Sabrina Beauvais et al. Acta Biomaterialia
- BMP signalling in skeletal development, disease and repair
- (2016) Valerie S. Salazar et al. Nature Reviews Endocrinology
- Creation of DNA aptamers against recombinant bone morphogenetic protein 15
- (2016) Jun Sheng Lin et al. REPRODUCTION FERTILITY AND DEVELOPMENT
- Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair
- (2016) Sonia Scarfì World Journal of Stem Cells
- BMP-2 Derived Peptide and Dexamethasone Incorporated Mesoporous Silica Nanoparticles for Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells
- (2015) Xiaojun Zhou et al. ACS Applied Materials & Interfaces
- A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis
- (2015) Georgina Kerr et al. ANGIOGENESIS
- Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome
- (2015) Elisa Degenkolbe et al. BONE
- Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors
- (2015) L. J. A. C. Hawinkels et al. CLINICAL CANCER RESEARCH
- Synergistic effect of HA and BMP-2 mimicking peptide on the bioactivity of HA/PMMA bone cement
- (2015) Zhenzhen Liu et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- The effects of a single intravenous injection of novel activin A/BMP-2 (AB204) on toxicity and the respiratory and central nervous systems
- (2015) Byung-Hak Yoon et al. DRUG AND CHEMICAL TOXICOLOGY
- Featured Article: microRNA-125a in pulmonary hypertension: Regulator of a proliferative phenotype of endothelial cells
- (2015) Lars C Huber et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II
- (2015) YUJING CAO et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- MiR542-3p Regulates the Epithelial-Mesenchymal Transition by Directly Targeting BMP7 in NRK52e
- (2015) Zhicheng Liu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nanotubes Functionalized with BMP2 Knuckle Peptide Improve the Osseointegration of Titanium Implants in Rabbits
- (2015) Yuanping Ma et al. Journal of Biomedical Nanotechnology
- Loss of BMPR2 leads to high bone mass due to increased osteoblast activity
- (2015) J. W. Lowery et al. JOURNAL OF CELL SCIENCE
- Twelve-month results of a multicenter, blinded, pilot study of a novel peptide (B2A) in promoting lumbar spine fusion
- (2015) Zeeshan Sardar et al. JOURNAL OF NEUROSURGERY-SPINE
- Osteogenic properties of a short BMP-2 chimera peptide
- (2015) Lucia Falcigno et al. JOURNAL OF PEPTIDE SCIENCE
- The activin- β A/BMP-2 chimera AB204 is a strong stimulator of adipogenesis
- (2015) Meejung Kim et al. Journal of Tissue Engineering and Regenerative Medicine
- BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease
- (2015) Hidemi Kajimoto et al. KIDNEY INTERNATIONAL
- BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells
- (2015) Jeong Seon Kim et al. Molecular Cancer
- MiR-26a Rescues Bone Regeneration Deficiency of Mesenchymal Stem Cells Derived From Osteoporotic Mice
- (2015) Yan Li et al. MOLECULAR THERAPY
- Targeting BMP signalling in cardiovascular disease and anaemia
- (2015) Nicholas W. Morrell et al. Nature Reviews Cardiology
- The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo
- (2015) Judith M. Neugebauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression and purification of active recombinant human bone morphogenetic 7-2 dimer fusion protein
- (2015) Jianli Dang et al. PROTEIN EXPRESSION AND PURIFICATION
- The toxicological evaluation of repetitive 2- and 4-week intravenous injection of Activin A/BMP-2 chimera (AB204) into rats
- (2015) Byung-Hak Yoon et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Regulation of intestinal stem cell fate specification
- (2015) Zhen Qi et al. Science China-Life Sciences
- The bone morphogenetic protein-2/7 heterodimer is a stronger inducer of bone regeneration than the individual homodimers in a rat spinal fusion model
- (2015) Tokimitsu Morimoto et al. Spine Journal
- Characterization of a shorter recombinant polypeptide chain of bone morphogenetic protein 2 on osteoblast behaviour
- (2015) Yufeng Zhang et al. BMC Oral Health
- Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency
- (2015) Rajeev Malhotra et al. PLoS One
- Uncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor Selectivity
- (2015) Abdelaziz Alsamarah et al. PLoS One
- Secreted type of amyloid precursor protein induces glial differentiation by stimulating the BMP/Smad signaling pathway
- (2014) Young-Don Kwak et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The BMP2 antagonist inhibitor L51P enhances the osteogenic potential of BMP2 by simultaneous and delayed synergism
- (2014) Hany Mohamed Khattab et al. BONE
- (4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy
- (2014) Yue Sheng et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mesenchymal stem cells ameliorate diabetic glomerular fibrosis in vivo and in vitro by inhibiting TGF-β signalling via secretion of bone morphogenetic protein 7
- (2014) Shasha Lv et al. Diabetes & Vascular Disease Research
- MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF- /BMP signaling
- (2014) A. Bhinge et al. EMBO JOURNAL
- Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation
- (2014) C. Mayeur et al. HAEMATOLOGICA
- Signaling Involved in Hair Follicle Morphogenesis and Development
- (2014) Pisal Rishikaysh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription
- (2014) Kimberly B. Zumbrennen-Bullough et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation
- (2014) Daniel Horbelt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Superior Angiogenic Potential of GDF-5 and GDF-5V453/V456 Compared with BMP-2 in a Rabbit Long-Bone Defect Model
- (2014) Kerstin Kleinschmidt et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2
- (2014) Byung-Hak Yoon et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Effect of initial pBMP-9 loading and collagen concentration on the kinetics of peptide release and a mathematical model of the delivery system
- (2014) Marc-Antoine Lauzon et al. JOURNAL OF CONTROLLED RELEASE
- Regulation of FSHβ induction in LβT2 cells by BMP2 and an Activin A/BMP2 chimera, AB215
- (2014) Jae Woo Jung et al. JOURNAL OF ENDOCRINOLOGY
- Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants
- (2014) Agustin H. Mohedas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Systemic Injection of CK2.3, a Novel Peptide Acting Downstream of Bone Morphogenetic Protein Receptor BMPRIa, Leads to Increased Trabecular Bone Mass
- (2014) Hemanth Akkiraju et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Combined Use of Low-Intensity Pulsed Ultrasound and rhBMP-2 to Enhance Bone Formation in a Rat Model of Critical Size Defect
- (2014) Siddhesh R. Angle et al. JOURNAL OF ORTHOPAEDIC TRAUMA
- Low-Intensity Pulsed Ultrasound Induces Osteogenic Differentiation of Human Periodontal Ligament Cells Through Activation of Bone Morphogenetic Protein-Smad Signaling
- (2014) Zun Yang et al. JOURNAL OF ULTRASOUND IN MEDICINE
- MB109 as bioactive human bone morphogenetic protein-9 refolded and purified from E. coli inclusion bodies
- (2014) Mario Meng-Chiang Kuo et al. Microbial Cell Factories
- Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity in immortalized human granulosa cells
- (2014) Hsun-Ming Chang et al. MOLECULAR HUMAN REPRODUCTION
- The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
- (2014) Gang Wu et al. NATURE GENETICS
- Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
- (2014) Pawel Buczkowicz et al. NATURE GENETICS
- Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
- (2014) Kathryn R Taylor et al. NATURE GENETICS
- Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
- (2014) Adam M Fontebasso et al. NATURE GENETICS
- Inhibition of BMP signaling suppresses metastasis in mammary cancer
- (2014) P Owens et al. ONCOGENE
- Primoridal germ cell specification: a context-dependent cellular differentiation event
- (2014) U. Gunesdogan et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Lung Remodeling in a Mouse Model of Asthma Involves a Balance between TGF-β1 and BMP-7
- (2014) Camila Leindecker Stumm et al. PLoS One
- miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells
- (2014) Heiko Fuchs et al. PLoS One
- Characterization of Activin/BMP2 Chimera, AB204, Formulated for Preclinical Studies
- (2014) Chihoon Ahn et al. PROTEIN AND PEPTIDE LETTERS
- Treatment of heterotopic ossification through remote ATP hydrolysis
- (2014) J. R. Peterson et al. Science Translational Medicine
- Roles of TGF-β family signals in the fate determination of pluripotent stem cells
- (2014) Fumiko Itoh et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation
- (2014) Yu Cao et al. Scientific Reports
- Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor
- (2013) Agustin H. Mohedas et al. ACS Chemical Biology
- Treatment with Anti–Gremlin 1 Antibody Ameliorates Chronic Hypoxia/SU5416–Induced Pulmonary Arterial Hypertension in Mice
- (2013) Loredana Ciuclan et al. AMERICAN JOURNAL OF PATHOLOGY
- Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-β and BMP signaling
- (2013) Lan Zhao et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells
- (2013) Sebastien P. Tabruyn et al. ANGIOGENESIS
- Serum-induced up-regulation of hepcidin expression involves the bone morphogenetic protein signaling pathway
- (2013) Nanda Kumar N. Shanmugam et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- BMP signaling in development and diseases: A pharmacological perspective
- (2013) Amitabha Bandyopadhyay et al. BIOCHEMICAL PHARMACOLOGY
- Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe
- (2013) Darren W. Engers et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD)
- (2013) Byung-Hak Yoon et al. BMB Reports
- Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling
- (2013) Chiara Garulli et al. CELLULAR SIGNALLING
- MicroRNA-26a Regulates Pathological and Physiological Angiogenesis by Targeting BMP/SMAD1 Signaling
- (2013) Basak Icli et al. CIRCULATION RESEARCH
- Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of Dalantercept, an Activin Receptor-like Kinase-1 Ligand Trap, in Patients with Advanced Cancer
- (2013) J. C. Bendell et al. CLINICAL CANCER RESEARCH
- SMAD1 Deficiency in Either Endothelial or Smooth Muscle Cells Can Predispose Mice to Pulmonary Hypertension
- (2013) Chul Han et al. HYPERTENSION
- Evaluation of the Osteogenic Activity of the BMP-2 Mimetic Peptide, PEP7, In Vitro and In Viv
- (2013) Eun-Jung Kang et al. INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
- The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
- (2013) Catherine E. Winbanks et al. JOURNAL OF CELL BIOLOGY
- Inhibition of BMP activity protects epithelial barrier function in lung injury
- (2013) Thomas Helbing et al. JOURNAL OF PATHOLOGY
- BMP signaling controls muscle mass
- (2013) Roberta Sartori et al. NATURE GENETICS
- BMP activation and Wnt-signalling affect biochemistry and functional biomechanical properties of cartilage tissue engineering constructs
- (2013) A. Krase et al. OSTEOARTHRITIS AND CARTILAGE
- Basolateral BMP Signaling in Polarized Epithelial Cells
- (2013) Masao Saitoh et al. PLoS One
- A New Class of Small Molecule Inhibitor of BMP Signaling
- (2013) Caroline E. Sanvitale et al. PLoS One
- Bone Morphogenetic Protein Type I Receptor Antagonists Decrease Growth and Induce Cell Death of Lung Cancer Cell Lines
- (2013) Elaine Langenfeld et al. PLoS One
- Low-Intensity Pulsed Ultrasound Accelerates Tooth Movement via Activation of the BMP-2 Signaling Pathway
- (2013) Hui Xue et al. PLoS One
- Heterodimeric BMP-2/7 Antagonizes the Inhibition of All-Trans Retinoic Acid and Promotes the Osteoblastogenesis
- (2013) Wenjuan Bi et al. PLoS One
- Controlled Multiple Growth Factor Delivery from Bone Tissue Engineering Scaffolds via Designed Affinity
- (2013) Darilis Suárez-González et al. TISSUE ENGINEERING PART A
- Inhibition of endogenous antagonists with an engineered BMP-2 variant increases BMP-2 efficacy in rat femoral defect healing
- (2012) Hans-Jörg Sebald et al. Acta Biomaterialia
- Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis
- (2012) Matthias Derwall et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Sildenafil Potentiates Bone Morphogenetic Protein Signaling in Pulmonary Arterial Smooth Muscle Cells and in Experimental Pulmonary Hypertension
- (2012) Jun Yang et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cilomilast enhances osteoblast differentiation of mesenchymal stem cells and bone formation induced by bone morphogenetic protein 2
- (2012) Maria Chiara Munisso et al. BIOCHIMIE
- Bone induction through controlled release of novel BMP-2-related peptide from PTMC11-F127-PTMC11hydrogels
- (2012) Shuo Tang et al. Biomedical Materials
- BMP9 and BMP10 are critical for postnatal retinal vascular remodeling
- (2012) N. Ricard et al. BLOOD
- L51P — A BMP2 variant with osteoinductive activity via inhibition of Noggin
- (2012) Christoph E. Albers et al. BONE
- Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells
- (2012) Ken-ichiro Tanaka et al. BONE
- Np63 -Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells
- (2012) A. L. Balboni et al. CANCER RESEARCH
- The Role of BMP2 Signaling in the Skeleton
- (2012) Jonathan W. Lowery et al. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
- ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway
- (2012) Bruno Larrivée et al. DEVELOPMENTAL CELL
- AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension
- (2012) Matthias Brock et al. EUROPEAN HEART JOURNAL
- 20-hydroxyecdysone-induced bone morphogenetic protein-2-dependent osteogenic differentiation through the ERK pathway in human periodontal ligament stem cells
- (2012) Cong-Xiang Jian et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Functions of BMP signaling in embryonic stem cell fate determination
- (2012) Zhongwei Li et al. EXPERIMENTAL CELL RESEARCH
- MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2
- (2012) Yang Zeng et al. FEBS LETTERS
- miR-26a is required for skeletal muscle differentiation and regeneration in mice
- (2012) B. K. Dey et al. GENES & DEVELOPMENT
- B2A, a receptor modulator, increases the growth of pluripotent and preosteoblast cells through bone morphogenetic protein receptors
- (2012) Y. Liu et al. GROWTH FACTORS
- B2A as a positive BMP receptor modulator
- (2012) Xinhua Lin et al. GROWTH FACTORS
- microRNA-145 in Barrett's oesophagus: regulating BMP4 signalling via GATA6
- (2012) Jantine W P M van Baal et al. GUT
- ACVR1, a Therapeutic Target of Fibrodysplasia Ossificans Progressiva, Is Negatively Regulated by miR-148a
- (2012) Hao Song et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- miR-30 Family Members Negatively Regulate Osteoblast Differentiation
- (2012) Tingting Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting
- (2012) Laurens A. van Meeteren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SnoN Suppresses Maturation of Chondrocytes by Mediating Signal Cross-talk between Transforming Growth Factor-β and Bone Morphogenetic Protein Pathways
- (2012) Ichiro Kawamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of MicroRNA-302 (miR-302) by Bone Morphogenetic Protein 4 (BMP4) Facilitates the BMP Signaling Pathway
- (2012) Hara Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice
- (2012) Ryuichiro Yamamoto et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Augmentation of smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice
- (2012) Yoshihiro Komatsu et al. JOURNAL OF BONE AND MINERAL RESEARCH
- An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland
- (2012) Yoshinori Matsumoto et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
- (2012) Hikaru Sugimoto et al. NATURE MEDICINE
- DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells
- (2012) Ada Ao et al. PLoS One
- A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength
- (2012) Marc Baud’huin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathogenic Mutation of ALK2 Inhibits Induced Pluripotent Stem Cell Reprogramming and Maintenance: Mechanisms of Reprogramming and Strategy for Drug Identification
- (2012) Makoto Hamasaki et al. STEM CELLS
- Dynamic Regulation of Bone Morphogenetic Proteins in Engineered Osteochondral Constructs by Biomechanical Stimulation
- (2012) Jin Nam et al. TISSUE ENGINEERING PART A
- E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study
- (2012) Saravanan Yuvaraj et al. Gastroenterology Research and Practice
- Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis
- (2011) Omar Saeed et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
- (2011) I. Theurl et al. BLOOD
- Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
- (2011) A. U. Steinbicker et al. BLOOD
- BMP4 Promotes Prostate Tumor Growth in Bone through Osteogenesis
- (2011) Y.-C. Lee et al. CANCER RESEARCH
- The specificities of small molecule inhibitors of the TGFß and BMP pathways
- (2011) Janis Vogt et al. CELLULAR SIGNALLING
- Targeted gene delivery of BMPR2 attenuates pulmonary hypertension
- (2011) A. M. Reynolds et al. EUROPEAN RESPIRATORY JOURNAL
- Silencing the FOP gene
- (2011) J W Lowery et al. GENE THERAPY
- Disease-causing allele-specific silencing against the ALK2 mutants, R206H and G356D, in fibrodysplasia ossificans progressiva
- (2011) M Takahashi et al. GENE THERAPY
- Restoration of normal BMP signaling levels and osteogenic differentiation in FOP mesenchymal progenitor cells by mutant allele-specific targeting
- (2011) J Kaplan et al. GENE THERAPY
- Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands
- (2011) Craig A. Harrison et al. GROWTH FACTORS
- The bone morphogenetic protein–hepcidin axis as a therapeutic target in inflammatory bowel disease
- (2011) Lijian Wang et al. INFLAMMATORY BOWEL DISEASES
- New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance
- (2011) Gerburg K. Schwaerzer et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
- (2011) Mirco Castoldi et al. JOURNAL OF CLINICAL INVESTIGATION
- Upregulation of Intervertebral Disc-Cell Matrix Synthesis by Pulsed Electromagnetic Field Is Mediated by Bone Morphogenetic Proteins
- (2011) Motohiro Okada et al. JOURNAL OF SPINAL DISORDERS & TECHNIQUES
- The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation
- (2011) J T Buijs et al. ONCOGENE
- BMP signaling in the nephron progenitor niche
- (2011) Leif Oxburgh et al. PEDIATRIC NEPHROLOGY
- MicroRNAs in Development and Disease
- (2011) Danish Sayed et al. PHYSIOLOGICAL REVIEWS
- Designer TGFβ Superfamily Ligands with Diversified Functionality
- (2011) George P. Allendorph et al. PLoS One
- mRNA expression profiling reveals conserved and non-conserved miR-140 targets
- (2011) Francisco Esteban Nicolas et al. RNA Biology
- MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling
- (2011) Jin-fang Zhang et al. RNA Biology
- BMP2/7 Heterodimer Can Modulate All Cellular Events of the In Vitro RANKL-Mediated Osteoclastogenesis, Respectively, in Different Dose Patterns
- (2011) Yuanna Zheng et al. TISSUE ENGINEERING PART A
- Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner
- (2010) Kartik Balachandran et al. AMERICAN JOURNAL OF PATHOLOGY
- Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension
- (2010) Benoit Rondelet et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The effect of two point mutations in GDF-5 on ectopic bone formation in a β-tricalciumphosphate scaffold
- (2010) Philip Kasten et al. BIOMATERIALS
- Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and/or BMPs mimetic peptides
- (2010) Omar F. Zouani et al. BIOMATERIALS
- Rapid cell culture and pre-clinical screening of a transforming growth factor-β (TGF-β) inhibitor for orthopaedics
- (2010) Aaron Schindeler et al. BMC MUSCULOSKELETAL DISORDERS
- Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro study
- (2010) Justus HW Jansen et al. BMC MUSCULOSKELETAL DISORDERS
- BMP signaling in vascular development and disease
- (2010) Jonathan W. Lowery et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression
- (2010) Ippei Kanazawa et al. ENDOCRINE JOURNAL
- Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells
- (2010) J.H. Boergermann et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Sildenafil Limits Monocrotaline-Induced Pulmonary Hypertension in Rats Through Suppression of Pulmonary Vascular Remodeling
- (2010) Chia-Hung Yen et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo
- (2010) Zhen-Yu Lin et al. JOURNAL OF CONTROLLED RELEASE
- Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
- (2010) Sara I. Cunha et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Virtual screening and selection of drug-like compounds to block noggin interaction with bone morphogenetic proteins
- (2010) Shaila Ahmed et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- MicroRNA miR-155 Inhibits Bone Morphogenetic Protein (BMP) Signaling and BMP-Mediated Epstein-Barr Virus Reactivation
- (2010) Q. Yin et al. JOURNAL OF VIROLOGY
- A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype
- (2010) Satoshi Kato et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth
- (2010) D. Mitchell et al. MOLECULAR CANCER THERAPEUTICS
- Bone Morphogenetic Protein-2 and -6 Heterodimer Illustrates the Nature of Ligand-Receptor Assembly
- (2010) Michael J. Isaacs et al. MOLECULAR ENDOCRINOLOGY
- BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells
- (2010) Elvira Valera et al. PLoS One
- Targeting of SMAD5 links microRNA-155 to the TGF- pathway and lymphomagenesis
- (2010) D. Rai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of embryonic stem cell self-renewal and differentiation by TGF-β family signaling
- (2010) Teng Fei et al. Science China-Life Sciences
- BMPs: From Bone to Body Morphogenetic Proteins
- (2010) D. Obradovic Wagner et al. Science Signaling
- Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation Propensity
- (2010) Dae-Sung Kim et al. Stem Cell Reviews and Reports
- Enhanced Bone Morphogenetic Protein-2-Induced Ectopic and Orthotopic Bone Formation by Intermittent Parathyroid Hormone (1–34) Administration
- (2010) Diederik H.R. Kempen et al. TISSUE ENGINEERING PART A
- Extracellular BMP-antagonist regulation in development and disease: tied up in knots
- (2010) David W. Walsh et al. TRENDS IN CELL BIOLOGY
- In VivoStructure−Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors
- (2009) Jijun Hao et al. ACS Chemical Biology
- Osteoblastic differentiation of human bone marrow stromal cells in self-assembled BMP-2 receptor-binding peptide-amphiphiles
- (2009) Jue-Yeon Lee et al. BIOMATERIALS
- Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morphogenetic protein-2 activity
- (2009) Motohiro Okada et al. CELL BIOCHEMISTRY AND FUNCTION
- Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension
- (2009) Lu Long et al. CIRCULATION
- Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway
- (2009) Matthias Brock et al. CIRCULATION RESEARCH
- MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads
- (2009) Charles E. Rogler et al. HEPATOLOGY
- miR-199a*, a Bone Morphogenic Protein 2-responsive MicroRNA, Regulates Chondrogenesis via Direct Targeting to Smad1
- (2009) Edward A. Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Local delivery of rolipram, a phosphodiesterase-4-specific inhibitor, augments bone morphogenetic protein-induced bone formation
- (2009) Yoshio Tokuhara et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo
- (2009) Masamichi Yamamoto et al. JOURNAL OF CELL BIOLOGY
- BMP4 regulates vascular progenitor development in human embryonic stem cells through a smad-dependent pathway
- (2009) Hao Bai et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Ceramic granules enhanced with B2A peptide for lumbar interbody spine fusion: an experimental study using an instrumented model in sheep
- (2009) Bryan W. Cunningham et al. JOURNAL OF NEUROSURGERY-SPINE
- Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from Flexbone, an elastomeric osteoconductive bone substitute
- (2009) Jianwen Xu et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
- (2009) Billy Andriopoulos Jr et al. NATURE GENETICS
- Inhibition of oocyte growth factors in vivo modulates ovarian folliculogenesis in neonatal and immature mice
- (2009) Samu Myllymaa et al. REPRODUCTION
- Murine Preosteoblast Differentiation Induced by a Peptide Derived from Bone Morphogenetic Proteins-9
- (2009) Eric Bergeron et al. TISSUE ENGINEERING PART A
- Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN
- (2009) Petra Seemann et al. PLoS Genetics
- Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline
- (2008) Matthew Thomas et al. AMERICAN JOURNAL OF PATHOLOGY
- Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression
- (2008) Ippei Kanazawa et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
- (2008) Gregory D. Cuny et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1–34) in metaphyseal bone healing
- (2008) Elise F. Morgan et al. BONE
- Bone morphogenetic protein 4 inhibits TGF-β2 stimulation of extracellular matrix proteins in optic nerve head cells: Role of gremlin in ECM modulation
- (2008) Gulab S. Zode et al. GLIA
- Synthetic peptide-coated bone mineral for enhanced osteoblastic activationin vitroandin vivo
- (2008) Jue-Yeon Lee et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Ultrasound increased BMP-2 expression via PI3K, Akt, c-Fos/c-Jun, and AP-1 pathways in cultured osteoblasts
- (2008) Chun-Han Hou et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Pulsed electromagnetic fields enhance BMP-2 dependent osteoblastic differentiation of human mesenchymal stem cells
- (2008) Z. Schwartz et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Effect of Grafting RGD and BMP-2 Protein-Derived Peptides to a Hydrogel Substrate on Osteogenic Differentiation of Marrow Stromal Cells
- (2008) Xuezhong He et al. LANGMUIR
- Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators
- (2008) Tatyana A. Souza et al. MOLECULAR ENDOCRINOLOGY
- BMP type I receptor inhibition reduces heterotopic ossification
- (2008) Paul B Yu et al. NATURE MEDICINE
- Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis?
- (2008) Tri Q. Nguyen et al. PHARMACEUTICAL RESEARCH
- Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells
- (2008) Jijun Hao et al. PLoS One
- A microRNA signature for a BMP2-induced osteoblast lineage commitment program
- (2008) Z. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- B2A Peptide on Ceramic Granules Enhance Posterolateral Spinal Fusion in Rabbits Compared With Autograft
- (2008) Joseph D. Smucker et al. SPINE
- Simvastatin Stimulates Chondrogenic Phenotype of Intervertebral Disc Cells Partially Through BMP-2 Pathway
- (2008) Huina Zhang et al. SPINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started