Article
Biotechnology & Applied Microbiology
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Yiru Fu, Jinlin Song
Summary: Low-intensity pulsed ultrasound (LIPUS) can improve orthodontic tooth movement and alveolar bone remodeling by promoting the interaction between osteoblasts and osteoclasts, thus enhancing the effectiveness of orthodontic treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jiao Xin, Xinxin Zhan, Fu Zheng, Huazhi Li, Yixiang Wang, Cuiying Li, Jiuhui Jiang
Summary: The study found that LFHIU can enhance overall tooth mobility in rat orthodontic treatment, while aspirin has the effect of slowing this trend. Ultrasound treatment can increase tooth movement speed, increase osteoclasts numbers, and elevate RANKL levels, but it can also lead to bone density reduction.
Article
Immunology
Qing Liao, Bao Jian Li, Yang Li, Yu Xiao, Hui Zeng, Jie Mei Liu, Li Xia Yuan, Gang Liu
Summary: Studies have shown that LIPUS-mediated BMSC-derived exosomes can promote cartilage regeneration, increase chondrocyte proliferation and extracellular matrix synthesis, and suppress inflammation. The underlying mechanism may involve the inhibition of IL-1 beta-induced activation of the NF-Kappa B pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agnes Schroeder, Joshua Gubernator, Alexandra Leikam, Ute Nazet, Fabian Cieplik, Jonathan Jantsch, Patrick Neubert, Jens Titze, Peter Proff, Christian Kirschneck
Summary: Dietary salt uptake and NFAT-5 play a role in osteoclast activity and orthodontic tooth movement, with high salt diet promoting periodontal bone loss and impaired OTM, while NFAT-5 deletion leads to increased osteoclast activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Yiming Chen, Huiyi Yang, Zhaojie Wang, Rongrong Zhu, Liming Cheng, Qian Cheng
Summary: This study investigated the promoting effects and mechanisms of low-intensity pulsed ultrasound (LIPUS) on the chondrogenic differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs), and evaluated its application value in articular cartilage defect repair. The results showed that LIPUS stimulation effectively promoted cartilage-related gene and protein expression, inhibited TNF-alpha gene expression in hUC-MSCs, and exhibited anti-inflammatory effects in C28/I2 cells. Furthermore, the repair of articular cartilage defects in rats was significantly improved after hUC-MSC transplantation and LIPUS stimulation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Anatomy & Morphology
Bo Huang, Yixuan Jiang, Liang Zhang, Bo Yang, Yanjun Guo, Xingmei Yang, Ping Gong
Summary: This study aimed to investigate the potential mechanism of low-intensity pulsed ultrasound (LIPUS) affecting the proliferation and myelinating activity of Schwann cells (SCs). The results showed that LIPUS with a duty ratio of 50% had the maximal effect in promoting SC proliferation and increasing the expression of key molecules involved in myelination. The NRG1/ErbB signaling pathway was identified as one of the mechanisms through which LIPUS could protect and promote nerve repair and regeneration.
Article
Physiology
Xiaoxiao Hu, Chensheng Lin, Ningsheng Ruan, Zhen Huang, Yanding Zhang, Xuefeng Hu
Summary: This study investigates the conservation of the atypical BMP canonical signaling pathway in human odontogenesis and reveals the functional operation of a pathway dependent on Smad1/5/8 but independent of Smad4 in human dental mesenchyme during early tooth development.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
A. Murashima-Suginami, H. Kiso, Y. Tokita, E. Mihara, Y. Nambu, R. Uozumi, Y. Tabata, K. Bessho, J. Takagi, M. Sugai, K. Takahashi
Summary: Deficiency in USAG-1 leads to supernumerary teeth formation, while antibodies against USAG-1 can accelerate tooth development. Blocking USAG-1 function can alleviate congenital tooth agenesis caused by various genetic abnormalities.
Article
Endocrinology & Metabolism
Xiaofang Zhu, Hao Yuan, Ouyang Ningjuan, Carroll Ann Trotman, Thomas E. Van Dyke, Jake Jinkun Chen, Guofang Shen
Summary: Corticotomy is effective but invasive for accelerating tooth movement in orthodontic treatment. This study found that 6-shogaol can promote osteoclast differentiation and induce transient osteopenia, accelerating tooth movement non-invasively. These results suggest a potential alternative method for faster tooth movement in orthodontic treatment.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Elif Tunc-Ozcan, Sarah M. Brooker, Jacqueline A. Bonds, Yung-Hsu Tsai, Radhika Rawat, Tammy L. McGuire, Chian-Yu Peng, John A. Kessler
Summary: Hippocampal BMP signaling is identified as a common pathway mediating the behavioral effects of multiple antidepressant classes and electroconvulsive therapy. Inhibition of hippocampal BMP signaling is shown to be both necessary and sufficient to mediate the effects of these treatments, involving a key role in neurogenesis in the hippocampus.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Nie Han, Weijun Jiang, Guanheng Li, Lingling Lu, Jiali Shan, Lan Feng, Lin Jin
Summary: This study aimed to investigate whether low-intensity pulsed ultrasound (LIPUS) could improve gastric emptying in diabetic gastroparesis rats by acting on the ST36 acupuncture point. The results showed that LIPUS significantly improved gastric emptying in diabetic rats and rescued the damaged interstitial cells of Cajal network by inhibiting the TNF-α/IKKβ/NF-κB signaling pathway.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Cell Biology
Cangwei Liu, Hao Guo, Ce Shi, Hongchen Sun
Summary: Short root anomaly (SRA) can cause tooth loss and affect patients' health. Dental implants have limitations compared to natural tooth roots, and tissue engineering-mediated root regeneration offers a more natural function. This article reviews the roles of Bone Morphogenetic Proteins (BMPs) in tooth root development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Shota Inoue, Changxin Li, Junpei Hatakeyama, Hanlin Jiang, Hiroshi Kuroki, Hideki Moriyama
Summary: Higher-intensity ultrasound has been shown to effectively accelerate fracture healing in an osteoporotic fracture model. It promotes chondrogenesis and hypertrophic differentiation of chondrocytes, increases osteoblasts and newly formed bone, and accelerates endochondral ossification during fracture healing. The mechanosensitive ion channel Piezo1 mediates ultrasound-stimulated fracture healing and bone formation.
Article
Acoustics
Thi-Thuyet Truong, Wen-Tai Chiu, Yi-Shyun Lai, Hsien Huang, Xiaoning Jiang, Chih-Chung Huang
Summary: This study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on the NSC-34 cell line, a model for motor neuron diseases (MND). The findings suggest that LIPUS stimulation can promote the maturation and proliferation of NSC-34 cells, potentially through the activation of Ca2+ signaling and transcription factors.
Article
Biochemistry & Molecular Biology
Daniel G. Blackmore, Fabrice Turpin, Tishila Palliyaguru, Harrison T. Evans, Antony Chicoteau, Wendy Lee, Matthew Pelekanos, Nghia Nguyen, Jae Song, Robert K. P. Sullivan, Pankaj Sah, Perry F. Bartlett, Jurgen Gotz
Summary: The study reveals that scanning ultrasound combined with microbubbles can fully restore LTP induction in the aged mouse brain, while ultrasound treatment alone can also improve LTP and spatial learning deficits in aged mice. This non-invasive therapeutic approach may enhance cognition in elderly humans.
MOLECULAR PSYCHIATRY
(2021)
Article
Critical Care Medicine
Michael Groeger, Melanie Hogg, Essam Abdelsalam, Sandra Kress, Andrea Hoffmann, Bettina Stahl, Veronique Saub, Nicole Denoix, Oscar McCook, Enrico Calzia, Eva-Maria Wolfschmitt, Ulrich Wachter, Josef A. Vogt, Rui Wang, Peter Radermacher, Tamara Merz, Benedikt L. Nussbaum
Summary: This study investigated the effects of sodium thiosulfate (Na2S2O3) administration during resuscitation from trauma-and-hemorrhage in mice under conditions of whole body cystathionine gamma-lyase (CSE) deficit. The results showed that Na2S2O3 exerted beneficial effects in terms of organ protection and anti-inflammatory properties, improving lung function, reducing norepinephrine requirements, increasing urine output, and regulating inflammatory response and oxidative stress in the kidney tissue. These findings suggest that Na2S2O3 could be a potential therapeutic option in the context of impaired CSE activity and/or reduced endogenous H2S availability.
Article
Pharmacology & Pharmacy
Yan Yu, Jing-Jing Li, Xiao-Qian He, Zi-Ying Lai, Rui Hao, Yu Qi, Dong-Qing Cao, Ming Fu, Hong Ma, Qiu-Chen Xie, Mu Sun, Zhi-Li Huang, Ling-Jing Jin, Hui-hui Sun, Ning Lu, Rui Wang, Wing-Ho Yung, Ying Huang
Summary: This study found that dysfunction of the 5-HT3R affects synaptic plasticity between hippocampal neurons, leading to impairment in spatial memory. This effect is mediated through the CB1R-GABA(A) pathway on the 5-HT3R.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Huiying Huang, Siqing Zhu, Yuemei Han, Dong Liu, Sihao Liu, Duoduo Lu, Rui Wang, Quankui Lin
Summary: Posterior capsule opacification (PCO) is a common complication in cataract surgery, primarily caused by residual lens epithelial cells. Despite advancements in IOL surface modification techniques for PCO prevention, issues such as long-term efficacy and intraocular biocompatibility remain. This study presents a novel IOL modification approach with enzymes for efficient PCO suppression without toxic drugs, showcasing promising results in in vitro and in vivo evaluations.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Zhangjing Ma, Kevin Y. Yang, Yu Huang, Kathy O. Lui
Summary: This article reviews the clinical characteristics of COVID-19 associated endothelial dysfunction, as well as the likely pathological mechanisms such as direct cell entry or indirect immune overreactions after SARS-CoV-2 infection. It also discusses potential biomarkers indicating disease severity, particularly related to abnormal thrombosis development in severe COVID-19, a fatal vascular complication. Furthermore, it summarizes clinical trials targeting the direct and indirect pathological pathways after SARS-CoV-2 infection to prevent or inhibit virus-induced endothelial disorders.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Hongsong Zhang, Li Xiang, Mingyu Huo, Yalan Wu, Mingyang Yu, Chi Wai Lau, Danyang Tian, Lingshan Gou, Yuhong Huang, Jiang-Yun Luo, Li Wang, Wencong Song, Juan Huang, Zongwei Cai, Shaoliang Chen, Xiao Yu Tian, Yu Huang
Summary: Exercise reduces body weight, improves insulin sensitivity, lowers BCAAs in plasma, and inhibits the upregulation of BCAAs and metabolites caused by BCAA supplementation in the subcutaneous white adipose tissue of obese mice. BCAA supplementation reverses the improved insulin sensitivity from exercise in obese mice, but has no effect in lean mice. BCAAs also increase lipogenesis gene expression in the subcutaneous white adipose tissue of exercised obese mice.
Article
Cell Biology
Lifang Han, Gang Wang, Shaopu Zhou, Chenghao Situ, Zhiming He, Yuying Li, Yudan Qiu, Yu Huang, Aimin Xu, Michael Tim Yun Ong, Huating Wang, Jianfa Zhang, Zhenguo Wu
Summary: Muscle regeneration is defective under diabetic conditions, and the mechanisms involve the inhibition of cell cycle re-entry, mediated by elevated extracellular adenosine and AMP. The equilibrative adenosine transporters (ENTs)-adenosine kinase (ADK)-AMPK signaling axis plays a crucial role in this process. Inhibition of ADK and ENTs may have the potential to restore tissue stem cell regeneration in diabetic patients.
Article
Pharmacology & Pharmacy
Zheling Feng, Jiali Chen, Cheng Chen, Lu Feng, Rui Wang, Jianzhong Zhu, Ruohan Lou, Jia Liu, Yang Ye, Ligen Lin
Summary: This study discovered that polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia cambogia have lipid-lowering effects and can induce browning of adipocytes. Among them, guttiferone J (GOJ) is the most potent inducer of browning, which activates the deacetylase SIRT3 to enhance mitochondrial biogenesis and thermogenesis. In high-fat diet-induced obese mice, GOJ protected against obesity and related disorders by promoting browning of adipose tissue.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Huanyu Ding, Minchun Jiang, Chi Wai Lau, Jianfang Luo, Andrew M. M. Chan, Li Wang, Yu Huang
Summary: YAP inhibition by CBL0137 is a promising therapeutic approach for atherosclerotic vascular disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Peripheral Vascular Disease
Rui Wang
Summary: Hypertension is a complex health challenge with multiple causes, while hydrogen sulfide (H2S) serves as a multifunctional gasotransmitter. Animal studies conducted 15 years ago have established the critical role of endogenous H2S deficiency in hypertension development, leading to further investigations into its cardiovascular effects and underlying molecular and cellular mechanisms. We are also beginning to understand the involvement of altered H2S metabolism in human hypertension. This article aims to provide a comprehensive understanding of H2S's roles in hypertension development in both animals and humans, and review H2S-based antihypertension therapeutic strategies.
Article
Biochemistry & Molecular Biology
Chak Kwong Cheng, Huanyu Ding, Minchun Jiang, Huiyong Yin, Maik Gollasch, Yu Huang
Summary: Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding the vasculature, exhibiting the phenotypes of white, beige and brown adipocytes. PVAT is actively involved in the regulation of reactive oxygen species (ROS) homeostasis and inflammation in the vascular system. The phenotype-genotype of PVAT varies in different regions of the vasculature and plays a role in cardiovascular pathogenesis. Treatments targeting PVAT may provide new therapeutic insights for cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike
Summary: Reactive sulfur species, such as cysteine hydropersulfide and glutathione persulfide, are produced abundantly in both prokaryotes and eukaryotes, including mammals. Cysteinyl-tRNA synthetase (CARS) has been identified as a new cysteine persulfide synthase (CPERS) responsible for the production of most reactive persulfides. However, the contribution of other enzymes, such as 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine beta-synthase (CBS), and cystathionine gamma-lyase (CSE), to reactive persulfide production is still debated. In this study, the authors used sulfur metabolome analysis to demonstrate that 3-MST, CBS, and CSE are not major sources of reactive persulfides in mammals, and CARS/CPERS is the principal enzyme involved.
Article
Chemistry, Medicinal
Rui Wang, Zhecheng Zhou, Xiaonan Wu, Xin Jiang, Linlin Zhuo, Mingzhe Liu, Hao Li, Xiangzheng Fu, Xiaojun Yao
Summary: This study proposes a feature-correction-based model for plant SSP recognition, called SE-SSP. The model uses Transformer encoders and a feature correction module to improve prediction performance, and applies contrastive learning strategy to mitigate the problem of sparse samples. Experimental results demonstrate the excellent performance of the proposed model.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Review
Chemistry, Multidisciplinary
Tayebeh Amanpour, Rui Wang
Summary: Sulfenamides are organosulfur compounds that have a nitrogen-sulfur single bond structure. They play important roles in polymers used in various fields such as medicine, agrochemicals, veterinary medications, and environmental studies. This review focuses on the chemical reactions leading to sulfenamide production and their applications in cell biology and biochemistry.
JOURNAL OF SULFUR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Min Chen, Rui Wang, Qing-Xuan Ren, Bin Li, Ping Li, Hua Yang, Wen Gao
Summary: In this study, an online PB reaction coupled with SFC-MS was established to analyze C--C bonds in UFAs. The setup allowed for rapid capture of both prototype and product ions of FAs at the same retention time, significantly enhancing the accuracy of lipid identification. Additionally, a high C--C bond conversion rate was achieved, and the method demonstrated excellent relative quantification abilities.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Zhaoyu Ran, Yaru Zhang, Zhen Luo, Yujie Zhu, Mingti Wang, Rui Wang, Jing Fu, Qing Shao, Hui Quan, Hao Yuan, Jun Hu, Jinliang He, Qi Li
Summary: This study demonstrates the improved dielectric and capacitive performance of a polypropylene composite by grafting a molecular semiconductor onto polypropylene chains. The grafted molecular semiconductor introduces deep traps to inhibit the migration of high-energy charge carriers and enhances the regulation effect by positively influencing the microstructure of the polymer. The composite exhibits reduced leakage current, dielectric loss, electric field distortion, and increased breakdown strength at high temperatures.
MATERIALS TODAY ENERGY
(2023)