Review
Biochemistry & Molecular Biology
Christina A. Daly, Eric T. Hall, Stacey K. Ogden
Summary: Cells communicate with their neighbors during development and tissue homeostasis to ensure coordinated responses to signals. One way this communication occurs is through specialized extensions called cytonemes. However, the molecular mechanisms of cytoneme initiation, growth, and signal delivery are still not fully understood.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Alann Thaffarell Portilho Souza, Helena Bacha Lopes, Fabiola Singaretti Oliveira, Denise Weffort, Gileade Pereira Freitas, Leticia Faustino Adolpho, Roger Rodrigo Fernandes, Adalberto Luiz Rosa, Marcio Mateus Beloti
Summary: Agrin may contribute to osteoblast differentiation through a potential Agrin-Wnt-BMP circuit. Disruption of Agrin affects osteoblast differentiation, and Agrin could be a candidate target for treating bone-related diseases and injuries.
CELL AND TISSUE RESEARCH
(2021)
Review
Genetics & Heredity
Afraah Cassim, Dineshani Hettiarachchi, Vajira H. W. Dissanayake
Summary: Syndactyly, a common congenital malformation characterized by webbing in adjacent digits, is tightly regulated by genetic pathways during embryogenesis. The exact developmental mechanism leading to this condition is still not well understood. This review discusses the interactions repressing interdigital cell death (ICD) in syndactyly and characterizes genes associated with non-syndromic and selected syndromes involving syndactyly. The controversies regarding syndactyly classification and the effect of non-coding elements are also evaluated.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Pediatrics
Fabian Doktor, Lina Antounians, Martin Lacher, Augusto Zani
Summary: Congenital lung malformations are a diverse group of anomalies including congenital pulmonary airway malformation (CPAM), bronchopulmonary sequestration (BPS), congenital lobar emphysema (CLE), bronchogenic cysts, and hybrid lesions. Little is known about the underlying signaling pathways and malignant transformation processes of these lesions. In the last decade, the use of transgenic/knockout animal models and next generation sequencing on surgical lung specimens has increased our understanding of the pathophysiology of these malformations. This article provides an overview of normal lung development and discusses the current knowledge on the pathophysiology and molecular pathways altered in each congenital lung malformation.
SEMINARS IN PEDIATRIC SURGERY
(2022)
Article
Developmental Biology
Benoit Haerlingen, Robert Opitz, Isabelle Vandernoot, Angelo Molinaro, Meghna Parakkal Shankar, Pierre Gillotay, Achim Trubiroha, Sabine Costagliola
Summary: Thyroid tissue is derived from ventral pharyngeal endoderm and defects in morphogenesis are a main cause of congenital thyroid diseases. Recent studies have revealed the importance of FGF and BMP signaling in thyroid specification, but the relationship between signaling cues and thyroid transcription factors is still unclear. By analyzing zebrafish embryos, researchers identified a population of Pax2a-expressing thyroid progenitor cells that show enhanced FGF signaling but lack Nkx2.4b expression and BMP signaling. Manipulation of FGF/BMP activities suggests that FGF signaling mainly regulates Pax2a expression, while BMP signaling regulates both Pax2a and Nkx2.4b expression. Similar expression dynamics were observed in mouse embryos, indicating that this refined model of thyroid cell specification is evolutionarily conserved in mammals.
Review
Pharmacology & Pharmacy
Jincai Chen, Xiaofei Liao, Juwen Gan
Summary: Osteoporosis is a disease characterized by continuous bone loss and increased fracture risk. Osthole, a natural compound derived from certain plants, shows promise in protecting against the development of osteoporosis and could potentially be developed into a treatment agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Amaya Garcia de Vinuesa, Gonzalo Sanchez-Duffhues, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van Der Kraan, Marie-Jose Goumans, Peter ten Dijke
Summary: Research indicates that Cripto is upregulated in osteoarthritis and promotes hypertrophic differentiation of chondrocytes, contributing to tissue calcification. It is associated with the TGF-β-ALK1-Cripto receptor complex, inducing catabolic signaling in chondrocytes.
JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Carlos Garcia-Padilla, Francisco Hernandez-Torres, Estefania Lozano-Velasco, Angel Duenas, Maria del Mar Munoz-Gallardo, Isabel S. Garcia-Valencia, Lledo Palencia-Vincent, Amelia Aranega, Diego Franco
Summary: Bmp and Fgf signaling are involved in embryonic development, and their modulation of microRNAs plays a crucial role in regulating cell fate during cardiomyogenesis and PE/ST development. However, the role of Bmp and Fgf signaling in mouse PE/ST development is different from that in chicken, and their impact on cardiomyogenesis and fibrogenesis is limited. Species-specific differences in regulating PE/ST cardiomyogenic lineage commitment are supported by the data.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Benjamin L. Martin
Summary: The discovery of mesoderm inducing signals and NMPs has revolutionized the study of vertebrate mesoderm induction and provided new insights into the mechanisms of cell fate determination and morphogenesis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Martha Elena Diaz-Hernandez, Claudio Ivan Galvan-Hernandez, Jessica Cristina Marin-Llera, Karen Camargo-Sosa, Marcia Bustamante, Sabina Wischin, Jesus Chimal-Monroy
Summary: The study investigates the initiation of cell death in the anterior margin of the limb to establish the ANZ through interactions of FGF, BMP, and WNT signaling. It demonstrates that the inhibition of WNT or FGF signaling, or the activation of BMP signaling, induces cell death in the anterior margin of the limb, with correlated regulation of Dkk, Fgf8, and Bmp4 expression. This work provides insights into the negative feedback loop between FGF8, BMP4, and DKK in controlling cell death in the anterior margin of the limb.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anthony J. Hayes, John Whitelock, James Melrose
Summary: The aim of this study was to investigate the roles of perlecan in the regulation of cartilage development and homeostasis. The study showed that perlecan interacts with various molecules to promote matrix stabilization, cellular proliferation, and tissue expansion. Furthermore, perlecan is involved in chromatin structure modulation and gene regulation. Snail-1 and FGF family members play important roles in chondrogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Liisa T. Kuhn, Tao Peng, Gloria Gronowicz, Marja M. Hurley
Summary: Endogenous levels of fibroblast growth factor-2 (FGF-2) decrease with age, and a personalized medicine approach should guide FGF-2 supplementation to avoid excessive bone resorption and cartilage formation, which both inhibit calvarial bone repair.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Developmental Biology
Yu-Lieh Lin, Ling Yu, Mingquan Yan, Katherine Zimmel, Osama Qureshi, Felisha Imholt, Tao Li, Ivan Ivanov, Regina Brunauer, Lindsay Dawson, Ken Muneoka
Summary: A mouse organoid culture model utilizing BMP2 and BMP9 was developed to regenerate articular cartilage, successfully differentiating clonal cell lines into articular chondrocytes and hypertrophic chondrocyte progenitor cells. By enhancing cell aggregation using BMP2 and inducing chondrogenesis with BMP9, organized layers of articular chondrocytes similar to native cartilage were differentiated and maintained their phenotype after transplantation. Additionally, a connective tissue layer containing chondrocyte progenitor cells demonstrated the coupling of progenitor cell sequestration with articular cartilage differentiation at a clonal level.
Article
Biochemistry & Molecular Biology
Fang Li, Qizhao Tan, Feng Li, Ke Zhang, Zhongjun Liu, Yun Tian, Tengjiao Zhu
Summary: This study reveals that hypoxia in subchondral bone plays a crucial role in the crosstalk between chondrocytes and osteoblasts, and promotes the shift of chondrocytes toward an OA-like phenotype probably by activating the Wnt/beta-catenin signaling pathway in osteoblasts.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Cell Biology
Alexander M. Lovely, Timothy J. Duerr, Qingchao Qiu, Santiago Galvan, S. Randal Voss, James R. Monaghan
Summary: The study shows that the Wnt signaling pathway plays a similar role in both limb development and limb regeneration in axolotl salamanders. This provides new insights into the interaction of Wnt signaling with other signaling pathways during salamander limb development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Mohd Parvez Khan, Kainat Khan, Prem Swaroop Yadav, Abhishek Kumar Singh, Aditi Nag, Paritosh Prasahar, Monika Mittal, Shyamsundar Pal China, Mahesh Chandra Tewari, Geet Kumar Nagar, Deepshikha Tewari, Arun Kumar Trivedi, Sabyasachi Sanyal, Amitabha Bandyopadhyay, Naibedya Chattopadhyay
Article
Endocrinology & Metabolism
Prem Swaroop Yadav, Mohd. Parvez Khan, Paritosh Prashar, Shivali Duggal, Srikanta Kumar Rath, Naibedya Chattopadhyay, Amitabha Bandyopadhyay
Article
Cell Biology
Monika Saxena, Paritosh Prashar, Prem Swaroop Yadav, Jonaki Sen
Article
Developmental Biology
Pratik Narendra Pratap Singh, Ayan Ray, Kimi Azad, Amitabha Bandyopadhyay
GENE EXPRESSION PATTERNS
(2016)
Article
Multidisciplinary Sciences
Sanjoy Kumar Khan, Prem Swaroop Yadav, Gene Elliott, Dorothy Zhang Hu, Ruoshi Xu, Yingzi Yang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Correction
Cell Biology
Monika Saxena, Paritosh Prashar, Prem Swaroop Yadav, Jonaki Sen
Article
Biology
Taifeng Zhou, Bo Gao, Yi Fan, Yuchen Liu, Shuhao Feng, Qian Cong, Xiaolei Zhang, Yaxing Zhou, Prem S. Yadav, Jiachen Lin, Nan Wu, Liang Zhao, Dongsheng Huang, Shuanhu Zhou, Peiqiang Su, Yingzi Yang
Article
Multidisciplinary Sciences
Prem Swaroop Yadav, Shuhao Feng, Qian Cong, Hanjun Kim, Yuchen Liu, Yingzi Yang
Summary: Job syndrome is a rare genetic disorder characterized by immune dysfunction and skeletal developmental abnormalities. Current treatment options are limited, but enhancing Wnt/β-catenin signaling could potentially reduce bone symptoms in patients with Job syndrome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Meeting Abstract
Endocrinology & Metabolism
Prem Swaroop Yadav, Garyfallia Papaioannou, Marie B. Demay
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Sanjoy Khan, Prem Yadav, Yingzi Yang, Gene Elliot
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Meeting Abstract
Endocrinology & Metabolism
M. P. Khan, K. Khan, P. S. Yadav, A. K. Singh, A. Nag, A. Bandyopadhyay, N. Chattopadhyay
OSTEOPOROSIS INTERNATIONAL
(2016)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
