Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation

Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle

(2014) Etienne Mouisel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Bone Morphogenetic Protein 2 Stimulates Noncanonical SMAD2/3 Signaling via the BMP Type 1A Receptor in Gonadotrope-Like Cells: Implications for FSH Synthesis

(2014) Ying Wang et al.   ENDOCRINOLOGY

Myostatin Stimulates, Not Inihibits, C2C12 Myoblast Proliferation

(2014) Buel D. Rodgers et al.   ENDOCRINOLOGY

Blockade of ActRIIB Signaling Triggers Muscle Fatigability and Metabolic Myopathy

(2014) Karima Relizani et al.   MOLECULAR THERAPY

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Molecular and cell-based therapies for muscle degenerations: a road under construction

(2014) Emanuele Berardi et al.   Frontiers in Physiology

Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor

(2013) Agustin H. Mohedas et al.   ACS Chemical Biology

Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe

(2013) Darren W. Engers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

A New Class of Small Molecule Inhibitor of BMP Signaling

(2013) Caroline E. Sanvitale et al.   PLoS One

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

(2012) Apirat Chaikuad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Corrigendum

(2011)   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The specificities of small molecule inhibitors of the TGFß and BMP pathways

(2011) Janis Vogt et al.   CELLULAR SIGNALLING

Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level?

(2011) Rizwan Qaisar et al.   FASEB JOURNAL

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin-resistance

(2011) Gerburg K. Schwaerzer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells

(2010) J.H. Boergermann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of endogenous TGF-β family in myogenic differentiation of C2C12 cells

(2010) Yuuma Furutani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model

(2010) SongTing Shi et al.   NEUROBIOLOGY OF DISEASE

Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression

(2009) Alex Hennebry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Intricacies of BMP receptor assembly

(2009) Joachim Nickel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Emerging role of bone morphogenetic proteins in angiogenesis

(2009) Laurent David et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Applications of small molecule BMP inhibitors in physiology and disease

(2009) Charles C. Hong et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

(2009) Jennifer N Cash et al.   EMBO JOURNAL

Bone morphogenetic protein receptors and signal transduction

(2009) K. Miyazono et al.   JOURNAL OF BIOCHEMISTRY

Transforming Growth Factor β Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

(2009) Katharine H. Wrighton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

(2008) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

(2008) Irwin M Liu et al.   EMBO JOURNAL

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

(2008) Frederick S. Kaplan et al.   HUMAN MUTATION

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators

(2008) Tatyana A. Souza et al.   MOLECULAR ENDOCRINOLOGY

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

How the Smads regulate transcription

(2007) Sarah Ross et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY