Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription

(2016) Laura Baranello et al.   CELL

End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair

(2016) Vijay Menon et al.   DNA REPAIR

Processing ribonucleotides incorporated during eukaryotic DNA replication

(2016) Jessica S. Williams et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals

(2016) Muzammil Ahmad et al.   NUCLEIC ACIDS RESEARCH

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

(2016) A. Rialdi et al.   SCIENCE

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

(2016) Afzal Husain et al.   Nature Communications

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

(2016) Jessica Marinello et al.   PLoS One

Shaping mitotic chromosomes: From classical concepts to molecular mechanisms

(2015) Marc Kschonsak et al.   BIOESSAYS

Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex

(2015) Chiaki Takahata et al.   CARCINOGENESIS

FEN1 participates in repair of the 5′-phosphotyrosyl terminus of DNA single-strand breaks

(2015) Yukiko Kametani et al.   CARCINOGENESIS

Ligand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity

(2015) Janusz Puc et al.   CELL

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

Direct Evidence for the Formation of Precatenanes during DNA Replication

(2015) Jorge Cebrián et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topoisomerase I Alone Is Sufficient to Produce Short DNA Deletions and Can Also Reverse Nicks at Ribonucleotide Sites

(2015) Shar-yin Naomi Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

“Breaking Up Is Hard to Do”: The Formation and Resolution of Sister Chromatid Intertwines

(2015) Jonathan Baxter   JOURNAL OF MOLECULAR BIOLOGY

Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity

(2015) Anna Maria D'Erchia et al.   MITOCHONDRION

Glucocorticoid Receptor Transcriptional Activation via the BRG1-Dependent Recruitment of TOP2β and Ku70/86

(2015) Kevin W. Trotter et al.   MOLECULAR AND CELLULAR BIOLOGY

Condensing chromosome condensation

(2015) Jason C. Bell et al.   NATURE CELL BIOLOGY

Reconstitution of mitotic chromatids with a minimum set of purified factors

(2015) Keishi Shintomi et al.   NATURE CELL BIOLOGY

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation

(2015) Puja Yadav et al.   NUCLEIC ACIDS RESEARCH

DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation

(2015) Morten Roedgaard et al.   PLoS One

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system

(2015) Ruth Stuckey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration

(2015) Salim Khiati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

(2015) Stephanie A. Schalbetter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage

(2015) Haiqing Fu et al.   Nature Communications

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution

(2015) Ronan Broderick et al.   Nature Communications

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

(2015) Christian F. Nielsen et al.   Nature Communications

Transcriptional elongation requires DNA break-induced signalling

(2015) Heeyoun Bunch et al.   Nature Communications

PTEN stabilizes TOP2A and regulates the DNA decatenation

(2015) Xi Kang et al.   Scientific Reports

Topoisomerase II and leukemia

(2014) MaryJean Pendleton et al.   Annals of the New York Academy of Sciences

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity

(2014) S. Khiati et al.   CLINICAL CANCER RESEARCH

The origins and processing of ultra fine anaphase DNA bridges

(2014) Ying Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

(2014) Yves Pommier et al.   DNA REPAIR

Tipin Functions in the Protection against Topoisomerase I Inhibitor

(2014) Yoshifumi Hosono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromosome length and perinuclear attachment constrain resolution of DNA intertwines

(2014) Iris Titos et al.   JOURNAL OF CELL BIOLOGY

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation

(2014) Yanzhong Yang et al.   MOLECULAR CELL

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

(2014) Fernando Gómez-Herreros et al.   NATURE GENETICS

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

(2014) Sachin Katyal et al.   NATURE NEUROSCIENCE

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II  and II  in vertebrate mitochondria

(2014) H. Zhang et al.   NUCLEIC ACIDS RESEARCH

The   isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells

(2014) C. J. Farr et al.   NUCLEIC ACIDS RESEARCH

Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability

(2014) Claudia Krawczyk et al.   NUCLEIC ACIDS RESEARCH

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

(2014) Benu Brata Das et al.   NUCLEIC ACIDS RESEARCH

Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1)

(2014) D. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase 1 inhibition reversibly impairs synaptic function

(2014) Angela M. Mabb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

(2014) Christian Königer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rationale to target the SWI/SNF complex for cancer therapy

(2014) Anja F. Hohmann et al.   TRENDS IN GENETICS

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

New Mechanistic and Functional Insights into DNA Topoisomerases

(2013) Stefanie Hartman Chen et al.   Annual Review of Biochemistry

Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p

(2013) S. Solier et al.   CANCER RESEARCH

Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

(2013) Y. Maede et al.   MOLECULAR CANCER THERAPEUTICS

Topoisomerases facilitate transcription of long genes linked to autism

(2013) Ian F. King et al.   NATURE

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

(2013) Emily C. Dykhuizen et al.   NATURE

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

(2013) Dongyi Xu et al.   NATURE NEUROSCIENCE

Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

(2013) Georg Stoll et al.   NATURE NEUROSCIENCE

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

(2013) Catherine Naughton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription-dependent dynamic supercoiling is a short-range genomic force

(2013) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts

(2013) Vincent Gaggioli et al.   NUCLEIC ACIDS RESEARCH

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

(2013) S.-y. N. Huang et al.   NUCLEIC ACIDS RESEARCH

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

(2013) Jessica Marinello et al.   NUCLEIC ACIDS RESEARCH

Phytochemicals as anticancer and chemopreventive topoisomerase II poisons

(2013) Adam C. Ketron et al.   PHYTOCHEMISTRY REVIEWS

Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases

(2013) S.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-loop formation atSnord116mediates topotecan inhibition ofUbe3a-antisenseand allele-specific chromatin decondensation

(2013) Weston T. Powell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cost of rNTP/dNTP pool imbalance at the replication fork

(2013) N. Y. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation

(2013) Katherine L. Furniss et al.   PLoS Genetics

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?

(2012) Ian G. Cowell et al.   CELL CYCLE

Local and global functions of Timeless and Tipin in replication fork protection

(2012) Adam R. Leman et al.   CELL CYCLE

Erratum: Interfacial inhibitors: targeting macromolecular complexes

(2012) Yves Pommier et al.   NATURE REVIEWS DRUG DISCOVERY

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Topoisomerase II is required for the production of long Pol II gene transcripts in yeast

(2012) Ricky S. Joshi et al.   NUCLEIC ACIDS RESEARCH

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

(2012) Zhihong Zeng et al.   NUCLEIC ACIDS RESEARCH

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase

(2012) Sébastien Rouzeau et al.   PLoS One

Model for MLL translocations in therapy-related leukemia involving topoisomerase II -mediated DNA strand breaks and gene proximity

(2012) I. G. Cowell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNA virus hijacks an incognito function of a DNA repair enzyme

(2012) R. Virgen-Slane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Topoisomerases Maintain Promoters in a State Competent for Transcriptional Activation in Saccharomyces cerevisiae

(2012) Jakob Madsen Pedersen et al.   PLoS Genetics

Chromosome Breakage Is Regulated by the Interaction of the BLM Helicase and Topoisomerase IIα

(2011) Beatriz Russell et al.   CANCER RESEARCH

The many facets of the Tim-Tipin protein families’ roles in chromosome biology

(2011) Ramsay J. McFarlane et al.   CELL CYCLE

Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells

(2011) Ruth E. Gonzalez et al.   CELL CYCLE

Transcription-Induced DNA Double Strand Breaks: Both Oncogenic Force and Potential Therapeutic Target?

(2011) M. C. Haffner et al.   CLINICAL CANCER RESEARCH

Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast

(2011) Nayun Kim et al.   DNA REPAIR

DNA Repair Factor MRE11/RAD50 Cleaves 3′-Phosphotyrosyl Bonds and Resects DNA to Repair Damage Caused by Topoisomerase 1 Poisons

(2011) Elizabeth J. Sacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

(2011) Marie Regairaz et al.   JOURNAL OF CELL BIOLOGY

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

(2011) Hsien-Sung Huang et al.   NATURE

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression

(2011) Mahesh Ramamoorthy et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

(2011) Yong-Wei Zhang et al.   NUCLEIC ACIDS RESEARCH

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast

(2011) A. S. Sperling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive Supercoiling of Mitotic DNA Drives Decatenation by Topoisomerase II in Eukaryotes

(2011) J. Baxter et al.   SCIENCE

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

New insights into the formation and resolution of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

(2011) Angela M. Mabb et al.   TRENDS IN NEUROSCIENCES

MOLECULAR PATHOGENESIS OF SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA

(2011) Melanie Joannides et al.   Mediterranean Journal of Hematology and Infectious Diseases

Anti-Scl-70 (topo-I) antibodies in SLE: Myth or reality?

(2010) Michael Mahler et al.   AUTOIMMUNITY REVIEWS

Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks

(2010) Laura M. Williamson et al.   CARCINOGENESIS

Cellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective

(2010) Daniel A. Koster et al.   CELL

Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy

(2010) Christian Tovar et al.   CELL CYCLE

DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions

(2010) Olivier Sordet et al.   CELL CYCLE

In front of and behind the replication fork: bacterial type IIA topoisomerases

(2010) Claudia Sissi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy

(2010) K. Chikamori et al.   CURRENT CANCER DRUG TARGETS

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

(2010) Michael C Haffner et al.   NATURE GENETICS

MRE11 Function in Response to Topoisomerase Poisons Is Independent of its Function in Double-Strand Break Repair in Saccharomyces cerevisiae

(2010) Nicolle K. Hamilton et al.   PLoS One

Drosophila topo III  is required for the maintenance of mitochondrial genome and male germ-line stem cells

(2010) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

(2010) B. B. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteins of the origin recognition complex (ORC) and DNA topoisomerases on mammalian chromatin

(2009) Hong-gang Hu et al.   BMC MOLECULAR BIOLOGY

Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription

(2009) Rodrigo Bermejo et al.   CELL

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

(2009) Benu Brata Das et al.   EMBO JOURNAL

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

(2009) Olivier Sordet et al.   EMBO REPORTS

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

(2009) Sandie Tuduri et al.   NATURE CELL BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Using 3′-Bridging Phosphorothiolates To Isolate the Forward DNA Cleavage Reaction of Human Topoisomerase IIα†

(2008) Joseph E. Deweese et al.   BIOCHEMISTRY

Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

(2008) Meelad M. Dawlaty et al.   CELL

A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition

(2008) O. Cuvier et al.   GENES & DEVELOPMENT

Hyperphosphorylation of RNA Polymerase II in Response to Topoisomerase I Cleavage Complexes and Its Association with Transcription- and BRCA1-dependent Degradation of Topoisomerase I

(2008) Olivier Sordet et al.   JOURNAL OF MOLECULAR BIOLOGY

Topoisomerase II Inactivation Prevents the Completion of DNA Replication in Budding Yeast

(2008) Jonathan Baxter et al.   MOLECULAR CELL

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts

(2008) T. S. Dexheimer et al.   NUCLEIC ACIDS RESEARCH

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH