Article
Multidisciplinary Sciences
Kim M. Stegmann, Antje Dickmanns, Natalie Heinen, Claudia Blaurock, Tim Karrasch, Angele Breithaupt, Robert Klopfleisch, Nadja Uhlig, Valentina Eberlein, Leila Issmail, Simon T. Herrmann, Amelie Schreieck, Evelyn Peelen, Hella Kohlhof, Balal Sadeghi, Alexander Riek, John R. Speakman, Uwe Gross, Dirk Gorlich, Daniel Vitt, Thorsten Muller, Thomas Grunwald, Stephanie Pfaender, Anne Balkema-Buschmann, Matthias Dobbelstein
Summary: This study demonstrates a strong synergy between the nucleoside analog N4-hydroxycytidine (NHC) and inhibitors of dihydroorotate dehydrogenase (DHODH) in inhibiting the replication of SARS-CoV-2. Inhibition of DHODH increases the incorporation of NHC into viral RNA, leading to defective virus genomes. The combination of NHC and DHODH inhibitors may improve therapy options for COVID-19.
Article
Biochemistry & Molecular Biology
Carolyn K. J. Young, Joel H. Wheeler, Md Mostafijur Rahman, Matthew J. Young
Summary: Nucleoside reverse transcriptase inhibitors may cause mitochondrial toxicity and affect mtDNA replication, with potential value for anticancer purposes. HepaRG cell line can be a useful model to study the toxic effects of NRTIs, observing changes in mtDNA levels and cellular bioenergetics parameters.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Guang Huan Shen, Joon Hee Hong
Summary: This review focuses on the synthesis of cyclic 5'-deoxynucleoside phosphonate analogs, discussing various methods for the formation of different alkyl moieties and the coupling of nucleobases with cyclic moieties. The biological activity of these analogs is summarized.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fahad Hussain, Fahad Imtiaz Rahman, Poushali Saha, Atsushi Mikami, Takashi Osawa, Satoshi Obika, S. M. Abdur Rahman
Summary: Multiple modified sugars and ribonucleoside analogs were synthesized in this study from alpha-D-glucose, showing potential peripheral anti-nociceptive characteristics and cytotoxicity against human HeLa cell line. Additionally, certain compounds demonstrated strong binding affinity to key enzymes and alternative mechanistic pathways, providing potential for future drug development.
Article
Oncology
Zhenjun Zhao, Kang He, Yu Zhang, Xiangwei Hua, Mingxuan Feng, Zhichong Zhao, Yuan Sun, Yuhui Jiang, Qiang Xia
Summary: XRCC2 plays a crucial role in mtDNA damage repair and HCC progression, while also revealing the potential anti-tumor effect of Tm.
Article
Biochemistry & Molecular Biology
Ziqiang Xia, Juzeng Zheng, Liang Zheng, Endian Zheng, Zhuolin Zou, Xiong Sheng, Jinming Wu
Summary: The prevalence of dyslipidemia in China is increasing annually, and research shows that dyslipidemia can impact HBeAg seroconversion in CHB patients receiving nucleoside analogues treatment, but does not affect virological response.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Chemistry, Medicinal
Yuki Yoshida, Ti Zheng, Wataru Tanabe, Fumiaki Tomoike, Fumitaka Hashiya, Tetsuro Suzuki, Shuto Hirota, Yuriko Saiki, Akira Horii, Akiyoshi Hirayama, Tomoyosi Soga, Yasuaki Kimura, Hiroshi Abe
Summary: In this study, we have developed a new type of biocompatible phosphate analog (fluorophosphoramidate, FPA) and investigated its function in vivo. By improving the molecular design of FPA, we found that it can function as a phosphate prodrug of nucleoside. Additionally, one of the synthesized FPA-gemcitabine derivatives showed superior toxicity to cancer cells.
Article
Multidisciplinary Sciences
Sarkar M. A. Kawsar, Mohammed A. Hosen, Sajjad Ahmad, Youness El Bakri, Hamid Laaroussi, Taibi Ben Hadda, Faisal A. Almalki, Yasuhiro Ozeki, Souraya Goumri-Said
Summary: The study focuses on the modification and analysis of the RNA-dependent RNA polymerase of SARS-CoV-2, revealing promising antiviral properties of the modified derivatives and suggesting them as potential inhibitors against SARS-CoV-2.
Article
Microbiology
Julia C. LeCher, Keivan Zandi, Vivian Vasconcelos Costa, Franck Amblard, Sijia Tao, Dharmeshkumar Patel, Sujin Lee, Felipe Rocha da Silva Santos, Matheus Rodrigues Goncalves, Celso Martins Queroz-Junior, Fernanda Martins Marim, Katie Musall, Shu Ling Goh, Tamara McBrayer, Jessica Downs-Bowen, Ramyani De, Niloufar Azadi, James Kohler, Mauro Martins Teixeira, Raymond F. Schinazi
Summary: This study reports potential antiviral drugs against yellow fever virus, showing low toxicity, high intracellular metabolism, and strong anti-YFV activity in different models. The findings provide a new therapeutic option for treating yellow fever virus infections.
Review
Microbiology
Kaiming Tao, Philip L. Tzou, Janin Nouhin, Hector Bonilla, Prasanna Jagannathan, Robert W. Shafer
Summary: This review summarizes a year of progress in developing antiviral therapies for COVID-19, covering efforts in preclinical and clinical drug development, with a focus on compounds inhibiting SARS-CoV-2 enzymes, virus entry, interferons, and repurposed drugs inhibiting host processes for viral replication. Additionally, it concludes with insights on lessons learned and challenges ahead in SARS-CoV-2 drug development.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Microbiology
Han Chen, Jessica L. Lawler, David J. Filman, James M. Hogle, Donald M. Coen
Summary: Nucleoside analogs are crucial in antiviral therapy, but drug resistance remains a challenge. A study on HCMV DNA polymerase revealed that an alanine-to-glycine substitution enhances resistance to ganciclovir by accelerating DNA primer extension, while also facilitating RNA primer extension, offering insights into novel drug resistance mechanisms and polymerase functions.
Article
Biochemistry & Molecular Biology
Miklos Bege, Alexandra Kiss, Ilona Bereczki, Jan Hodek, Lenke Polyak, Gabor Szeman-Nagy, Lieve Naesens, Jan Weber, Aniko Borbas
Summary: In this study, d-arabinofuranosyl-pyrimidine and -purine nucleoside analogues containing alkylthio-, acetylthio- or 1-thiosugar substituents at the C2' position were synthesized by photoinitiated, radical-mediated hydrothiolation reactions. Some of these compounds exhibited selective cytotoxicity against tumor cells and also showed antiviral activity against SARS-CoV-2 and/or HCoV-229E.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Organic
Vladimir E. Kataev, Bulat F. Garifullin
Summary: The minireview discusses the modification of native nucleosides leading to the synthesis of diverse nucleoside analog libraries. It focuses on prodrug forms and antiviral cyclic nucleoside analogs, listing approved drugs for HIV, hepatitis B, C, and influenza, as well as those in clinical trials. It also mentions nucleoside analogs inhibiting the replication of SARS-CoV and MERS-CoV, including remdesivir used in the fight against COVID-19.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Lucas Mele, Raphael El Bekri Saudain, Jean-Luc Pirat, David Virieux, Tahar Ayad
Summary: A simple and rapid microwave-assisted protocol for the selective alkaline hydrolysis of phosphonate diesters has been developed, allowing efficient access to a wide variety of diversely substituted phosphonic acid monoesters. Conventional approaches struggle to obtain such compounds.
Article
Gastroenterology & Hepatology
Jonggi Choi, Chanyoung Jo, Young-Suk Lim
Summary: This study compared HCC recurrence and survival in HBV-related HCC patients treated with TDF or ETV after surgical resection, finding that TDF therapy was associated with a significantly lower risk of HCC recurrence and better overall survival.
Article
Multidisciplinary Sciences
Salim Khiati, Simone A. Baechler, Valentina M. Factor, Hongliang Zhang, Shar-yin N. Huang, Ilaria Dalla Rosa, Carole Sourbier, Leonard Neckers, Snorri S. Thorgeirsson, Yves Pommier
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Gokhan Akman, Radha Desai, Laura J. Bailey, Takehiro Yasukawa, Ilaria Dalla Rosa, Romina Durigon, J. Bradley Holmes, Chloe F. Moss, Mara Mennuni, Henry Houlden, Robert J. Crouch, Michael G. Hanna, Robert D. S. Pitceathly, Antonella Spinazzola, Ian J. Holt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Genetics & Heredity
Ilaria Dalla Rosa, Yolanda Camara, Romina Durigon, Chloe F. Moss, Sara Vidoni, Gokhan Akman, Lilian Hunt, Mark A. Johnson, Sarah Grocott, Liya Wang, David R. Thorburn, Michio Hirano, Joanna Poulton, Robert W. Taylor, Greg Elgar, Ramon Marti, Peter Voshol, Ian J. Holt, Antonella Spinazzola
Article
Biochemistry & Molecular Biology
Ilaria Dalla Rosa, Hongliang Zhang, Salim Khiati, Xiaolin Wu, Yves Pommier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Cell Biology
Jamal Wakim, David Goudenege, Rodolphe Perrot, Naig Gueguen, Valerie Desquiret-Dumas, Juan Manuel Chao de la Barca, Ilaria Dalla Rosa, Florence Manero, Morgane Le Mao, Stephanie Chupin, Arnaud Chevrollier, Vincent Procaccio, Dominique Bonneau, David C. Logan, Pascal Reynier, Guy Lenaers, Salim Khiati
JOURNAL OF CELL SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Chloe F. Moss, Ilaria Dalla Rosa, Lilian E. Hunt, Takehiro Yasukawa, Robert Young, Aleck W. E. Jones, Kaalak Reddy, Radha Desai, Sam Virtue, Greg Elgar, Peter Voshol, Martin S. Taylor, Ian J. Holt, Martin A. M. Reijns, Antonella Spinazzola
NUCLEIC ACIDS RESEARCH
(2017)
Article
Medicine, Research & Experimental
Romina Durigon, Alice L. Mitchell, Aleck W. E. Jones, Andreea Manole, Mara Mennuni, Elizabeth M. A. Hirst, Henry Houlden, Giuseppe Maragni, Serena Lattante, Paolo Niccolo' Doronzio, Ilaria Dalla Rosa, Marcella Zollino, Ian J. Holt, Antonella Spinazzola
EMBO MOLECULAR MEDICINE
(2018)
Article
Oncology
Salim Khiati, Ilaria Dalla Rosa, Carole Sourbier, Xuefei Ma, V. Ashutosh Rao, Leonard M. Neckers, Hongliang Zhang, Yves Pommier
CLINICAL CANCER RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Ilaria Dalla Rosa, Shar-yin N. Huang, Keli Agama, Salim Khiati, Hongliang Zhang, Yves Pommier
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Stefan Sobek, Ilaria Dalla Rosa, Yves Pommier, Beatrice Bornholz, Faiza Kalfalah, Hongliang Zhang, Rudolf J. Wiesner, Juergen-Christoph von Kleist-Retzow, Frank Hillebrand, Heiner Schaal, Christian Mielke, Morten O. Christensen, Fritz Boege
NUCLEIC ACIDS RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Ilaria Dalla Rosa, Romina Durigon, Sarah F. Pearce, Joanna Rorbach, Elizabeth M. A. Hirst, Sara Vidoni, Aurelio Reyes, Gloria Brea-Calvo, Michal Minczuk, Michael W. Woellhaf, Johannes M. Herrmann, Martijn A. Huynen, Ian J. Holt, Antonella Spinazzola
NUCLEIC ACIDS RESEARCH
(2014)
Article
Multidisciplinary Sciences
S. A. Baechler, V. M. Factor, I Dalla Rosa, A. Ravji, D. Becker, S. Khiati, L. M. Miller Jenkins, M. Lang, C. Sourbier, S. A. Michaels, L. M. Neckers, H. L. Zhang, A. Spinazzola, S. N. Huang, J. U. Marquardt, Y. Pommier
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Enrico Bugiardini, Alice L. Mitchell, Ilaria Dalla Rosa, Hue-Tran Horning-Do, Alan M. Pitmann, Olivia Poole, Janice L. Holton, Sachit Shah, Cathy Woodward, Iain Hargreaves, Rosaline Quinlivan, Alexey Amunts, Rudolf J. Wiesner, Henry Houlden, Ian J. Holt, Michael G. Hanna, Robert D. S. Pitceathly, Antonella Spinazzola
HUMAN MOLECULAR GENETICS
(2019)
Article
Clinical Neurology
Radha Desai, Ann E. Frazier, Romina Durigon, Harshil Patel, Aleck W. Jones, Ilaria Dalla Rosa, Nicole J. Lake, Alison G. Compton, Hayley S. Mountford, Elena J. Tucker, Alice L. R. Mitchell, Deborah Jackson, Abdul Sesay, Miriam Di Re, Lambert P. van den Heuvel, Derek Burke, David Francis, Sebastian Lunke, George McGillivray, Simone Mandelstam, Fanny Mochel, Boris Keren, Claude Jardel, Anne M. Turner, P. Ian Andrews, Jan Smeitink, Johannes N. Spelbrink, Simon J. Heales, Masakazu Kohda, Akira Ohtake, Kei Murayama, Yasushi Okazaki, Anne Lombes, Ian J. Holt, David R. Thorburn, Antonella Spinazzola
Article
Pharmacology & Pharmacy
Salim Khiati, Yeonee Seol, Keli Agama, Ilaria Dalla Rosa, Surbhi Agrawal, Katherine Fesen, Hongliang Zhang, Keir C. Neuman, Yves Pommier
MOLECULAR PHARMACOLOGY
(2014)