TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

Generation of assays and antibodies to facilitate the study of human 5′-tyrosyl DNA phosphodiesterase

(2013) Graeme Thomson et al.   ANALYTICAL BIOCHEMISTRY

Topoisomerases facilitate transcription of long genes linked to autism

(2013) Ian F. King et al.   NATURE

Gene regulation and priming by topoisomerase IIα in embryonic stem cells

(2013) Sudhir Thakurela et al.   Nature Communications

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2

(2012) Matthew J Schellenberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2

(2012) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

(2012) Zhihong Zeng et al.   NUCLEIC ACIDS RESEARCH

cn.MOPS: mixture of Poissons for discovering copy number variations in next-generation sequencing data with a low false discovery rate

(2012) Günter Klambauer et al.   NUCLEIC ACIDS RESEARCH

Target genes of Topoisomerase II  regulate neuronal survival and are defined by their chromatin state

(2012) V. K. Tiwari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SVA: software for annotating and visualizing sequenced human genomes

(2011) Dongliang Ge et al.   BIOINFORMATICS

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

(2010) Michael C Haffner et al.   NATURE GENETICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

The Characterization of Twenty Sequenced Human Genomes

(2010) Kimberly Pelak et al.   PLoS Genetics

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Functional annotations improve the predictive score of human disease-related mutations in proteins

(2009) Remo Calabrese et al.   HUMAN MUTATION

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1

(2009) Youngsoo Lee et al.   NATURE NEUROSCIENCE