In Vitro α-Glucosidase and α-Amylase Inhibition, Cytotoxicity and Free Radical Scavenging Profiling of the 6-Halogeno and Mixed 6,8-Dihalogenated 2-Aryl-4-methyl-1,2-dihydroquinazoline 3-Oxides

New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use

(2022) Davide Benedetto Tiz et al.   MOLECULES

The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

(2022) Jinfeng Shao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An in vitro and in silico α-amylase/α-glucosidase/protein tyrosine phosphatase 1 beta & radical scavenging profiling of the 3,5,7-tricarbo substituted 1H-indazoles

(2022) Malose J. Mphahlele et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of Radioiodinated Compounds. Classical Approaches and Achievements of Recent Years

(2022) Stanislav A. Petrov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides

(2022) Malose J. Mphahlele   MOLECULES

Food-derived non-phenolic α-amylase and α-glucosidase inhibitors for controlling starch digestion rate and guiding diabetes-friendly recipes

(2021) Xiaoxiao Li et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Synthesis, in vitro and in silico enzyme (COX-1/2 & LOX-5), free radical scavenging and cytotoxicity profiling of the 2,4-dicarbo substituted quinazoline 3-oxides

(2021) Malose J. Mphahlele et al.   MEDICINAL CHEMISTRY RESEARCH

Methods to evaluate the scavenging activity of antioxidants toward reactive oxygen and nitrogen species (IUPAC Technical Report)

(2021) Reşat Apak et al.   PURE AND APPLIED CHEMISTRY

Synthesis, α-glucosidase inhibition and antioxidant activity of the 7-carbo–substituted 5-bromo-3-methylindazoles

(2020) Malose J. Mphahlele et al.   BIOORGANIC CHEMISTRY

Management and Prevention Strategies for Non-communicable Diseases (NCDs) and Their Risk Factors

(2020) Aida Budreviciute et al.   Frontiers in Public Health

Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N-Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia-Selective Prodrugs

(2019) Xiulong Shen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists

(2019) Fengbin Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An Convenient Approach to 2,4-Disubstituted Quinazoline 3-Oxides Using active MnO2 as Oxidant

(2019) Yiyuan Peng et al.   CANADIAN JOURNAL OF CHEMISTRY

Detection and quantification of nitric oxide–derived oxidants in biological systems

(2019) Matías N. Möller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Halogenating Enzymes for Active Agent Synthesis: First Steps Are Done and Many Have to Follow

(2019) Alexander Veljko Fejzagić et al.   MOLECULES

Synthesis and molecular docking studies of imines as α-glucosidase and α-amylase inhibitors

(2019) Analy Aispuro-Pérez et al.   BIOORGANIC CHEMISTRY

Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree?

(2019) Balaraman Kalyanaraman   Redox Biology

Investigation the interaction between procyanidin dimer and α-amylase: Spectroscopic analyses and molecular docking simulation

(2018) Taotao Dai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Challenges and perspectives in the treatment of diabetes associated breast cancer

(2018) Samson Mathews Samuel et al.   CANCER TREATMENT REVIEWS

Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

(2017) Arun Chaudhury et al.   Frontiers in Endocrinology

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

(2016) Vibha Rani et al.   LIFE SCIENCES

Halogen-directed drug design for Alzheimer’s disease: a combined density functional and molecular docking study

(2016) Adhip Rahman et al.   SpringerPlus

Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents

(2015) A.M. Mfuh et al.   CURRENT MEDICINAL CHEMISTRY

Advantages and limitations of common testing methods for antioxidants

(2015) R. Amorati et al.   FREE RADICAL RESEARCH

Advanced glycation End-products (AGEs): an emerging concern for processed food industries

(2015) Chetan Sharma et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

The nature of NO-bonding in N-oxide group

(2015) Marlena Łukomska et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Substituent effect on the properties of pyridine-N-oxides

(2015) Natalya V. Belova et al.   STRUCTURAL CHEMISTRY

Conformational restriction: an effective tactic in 'follow-on'-based drug discovery

(2014) Zengjun Fang et al.   Future Medicinal Chemistry

Determination of the position of the N-O function in substituted pyrazine N-oxides by chemometric analysis of carbon-13 nuclear magnetic resonance data

(2013) Matias Butler et al.   JOURNAL OF MOLECULAR STRUCTURE

Visible light-mediated synthesis of quinazolines from 1,2-dihydroquinazoline 3-oxides

(2013) Yi-Chou Chen et al.   TETRAHEDRON

Halogen bonding for rational drug design and new drug discovery

(2012) Yunxiang Lu et al.   Expert Opinion on Drug Discovery

WinGXandORTEP for Windows: an update

(2012) Louis J. Farrugia   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

(2012) Rainer Wilcken et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Halogenated Compounds from Marine Algae

(2010) Maria Teresa Cabrita et al.   Marine Drugs

Nonbonding interactions of organic halogens in biological systems: implications for drug discovery and biomolecular design

(2010) Yunxiang Lu et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

(2010) Lara Gibellini et al.   Cancers

Conformational Analysis of Drug Molecules: A Practical Exercise in the Medicinal Chemistry Course

(2009) Elizabeth Yuriev et al.   JOURNAL OF CHEMICAL EDUCATION

Halogen BondingA Novel Interaction for Rational Drug Design?

(2009) Yunxiang Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The unique role of halogen substituents in the design of modern agrochemicals

(2009) Peter Jeschke   PEST MANAGEMENT SCIENCE