Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases
出版年份 2023 全文链接
标题
Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases
作者
关键词
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出版物
Experimental Neurobiology
Volume 32, Issue 4, Pages 216-246
出版商
The Korean Society for Brain and Neural Science
发表日期
2023-09-26
DOI
10.5607/en23014
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Brain Research Bulletin Special Issue: Brain–body communication in health and diseases Brain–spleen axis in health and diseases: a review and future perspective
- (2022) Yan Wei et al. BRAIN RESEARCH BULLETIN
- Skin amyloid deposits and nerve fiber loss as markers of neuropathy onset and progression in hereditary transthyretin amyloidosis
- (2022) Luca Leonardi et al. EUROPEAN JOURNAL OF NEUROLOGY
- Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
- (2022) Thomas E. Mahan et al. Molecular Neurodegeneration
- The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
- (2022) Eric Karran et al. NATURE REVIEWS DRUG DISCOVERY
- Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
- (2022) Ju-Hyun Lee et al. NATURE NEUROSCIENCE
- First‐in‐human study of blood amyloid β removal from early Alzheimer's disease patients with normal kidney function
- (2022) Midori Hasegawa et al. THERAPEUTIC APHERESIS AND DIALYSIS
- Immunotherapy for Alzheimer’s disease: targeting β-amyloid and beyond
- (2022) Chenghuan Song et al. Translational Neurodegeneration
- Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease
- (2022) Yeon Ha Ju et al. Cell Metabolism
- Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease
- (2022) Deepali Singh Journal of Neuroinflammation
- HEBP1 - An early trigger for neuronal cell death and circuit dysfunction in Alzheimer’s disease
- (2022) John Jia En Chua SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Photo-Oxygenation as a New Therapeutic Strategy for Neurodegenerative Proteinopathies by Enhancing the Clearance of Amyloid Proteins
- (2022) Ikumi Tomizawa et al. Frontiers in Aging Neuroscience
- Amyloid fibril reduction through covalently modified lysine in HEWL and insulin
- (2022) Mohsen Rezaei et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
- (2022) Na Zhao et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Aβ Peptides
- (2022) Linda Hanbouch et al. MOLECULAR NEUROBIOLOGY
- Ectodermal origins of the skin-brain axis: a novel model for the developing brain, inflammation, and neurodevelopmental conditions
- (2022) C. Jameson et al. MOLECULAR PSYCHIATRY
- Insights into Non-Proteolytic Inhibitory Mechanisms of Polymorphic Early-Stage Amyloid β Oligomers by Insulin Degrading Enzyme
- (2022) Karina Abramov-Harpaz et al. Biomolecules
- The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes
- (2021) Timo Jan Oberstein et al. Frontiers in Molecular Neuroscience
- Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models
- (2021) Tong Wu et al. Aging-US
- APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics
- (2021) Mohammed Amir Husain et al. Frontiers in Neuroscience
- Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer’s disease mice
- (2021) Shuta Ozawa et al. BRAIN
- Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease
- (2021) Ding-Yuan Tian et al. MOLECULAR PSYCHIATRY
- Transmission of cerebral amyloid pathology by peripheral administration of misfolded Aβ aggregates
- (2021) Rodrigo Morales et al. MOLECULAR PSYCHIATRY
- Investigation of the role of matrix metalloproteinases in the genetic etiology of Alzheimer's disease
- (2021) Julie Hoogmartens et al. NEUROBIOLOGY OF AGING
- NAC blocks Cystatin C amyloid complex aggregation in a cell system and in skin of HCCAA patients
- (2021) Michael E. March et al. Nature Communications
- Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model
- (2021) Christian Humpel Frontiers in Aging Neuroscience
- Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease
- (2021) Jong-Sung Park et al. Acta Neuropathologica Communications
- Aβ31–35 Decreases Neprilysin-Mediated Alzheimer’s Amyloid-β Peptide Degradation
- (2021) José P. Leite et al. ACS Chemical Neuroscience
- Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-brain Barrier in Alzheimer’s Disease
- (2021) Rui Zhou et al. Current Alzheimer Research
- Protective Role of a Donepezil-Huprine Hybrid against the β-Amyloid (1-42) Effect on Human Erythrocytes
- (2021) Pablo Zambrano et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review
- (2021) Tien-Wei Yu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Use of Serum Matrix Metalloproteinases in Cerebral Amyloid Angiopathy-Related Intracerebral Hemorrhage and Cognitive Impairment
- (2021) Mingxu Xia et al. JOURNAL OF ALZHEIMERS DISEASE
- Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme
- (2021) Bikash R. Sahoo et al. JOURNAL OF MOLECULAR BIOLOGY
- Combined Subcutaneous Fat Aspirate and Skin Tru-Cut Biopsy for Amyloid Screening in Patients with Suspected Systemic Amyloidosis
- (2021) Charlotte Toftmann Hansen et al. MOLECULES
- Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation
- (2021) Shady Estfanous et al. Frontiers in Immunology
- Serum Amyloid Beta42 Is Not Eliminated by the Cirrhotic Liver: A Pilot Study
- (2021) Reiner Wiest et al. Journal of Clinical Medicine
- Physiological clearance of Aβ by spleen and splenectomy aggravates Alzheimer‐type pathogenesis
- (2021) Zhong‐Yuan Yu et al. AGING CELL
- Assessment of lipophilic fluorescence products in β-amyloid-induced cognitive decline: A parallel track in hippocampus, CSF, plasma and erythrocytes
- (2021) Sepideh Tarbali et al. EXPERIMENTAL GERONTOLOGY
- Levels of Angiotensin-Converting Enzyme and Apolipoproteins Are Associated with Alzheimer’s Disease and Cardiovascular Diseases
- (2021) Chun Xu et al. Cells
- Kai-Xin-San, a Chinese Herbal Decoction, Accelerates the Degradation of β-Amyloid by Enhancing the Expression of Neprilysin in Rats
- (2020) Na Wang et al. Evidence-based Complementary and Alternative Medicine
- Potential Therapeutic Approaches for Cerebral Amyloid Angiopathy and Alzheimer’s Disease
- (2020) Masashi Tanaka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer’s disease
- (2020) Kritleen K. Bawa et al. Journal of Neuroinflammation
- Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner
- (2020) Keyana N. Porter et al. Frontiers in Aging Neuroscience
- Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives
- (2020) Yuan Cheng et al. Translational Neurodegeneration
- Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ
- (2020) Eriko Kuroda et al. NEUROSCIENCE
- Protein kinases A and C regulate amyloid-β degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes
- (2020) Naoki Yamamoto et al. NEUROSCIENCE RESEARCH
- Selection of mutant µplasmin for amyloid-β cleavage in vivo
- (2020) Dongying Yang et al. Scientific Reports
- Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models
- (2020) Ying-Wooi Wan et al. Cell Reports
- APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease
- (2020) Hussein N. Yassine et al. Frontiers in Aging Neuroscience
- Relationship Between Peripheral Transport Proteins and Plasma Amyloid-β in Patients with Alzheimer’s Disease were Different from Cognitively Normal Controls: A Propensity Score Matching Analysis
- (2020) Ling Gao et al. JOURNAL OF ALZHEIMERS DISEASE
- Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme
- (2020) Hongjun Fu et al. NEUROSCIENCE
- Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model
- (2020) Mengmeng Ma et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
- (2020) Heejung Chun et al. NATURE NEUROSCIENCE
- Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
- (2020) Fangda Leng et al. Nature Reviews Neurology
- Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
- (2020) Si-Han Chen et al. Translational Psychiatry
- Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection
- (2020) Madeleine R. Brown et al. Frontiers in Molecular Neuroscience
- Associations between brain amyloid accumulation and the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers
- (2020) Michael Ouk et al. NEUROBIOLOGY OF AGING
- Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease
- (2019) Jong-Hyun Park et al. Science Advances
- Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
- (2019) Li Zhong et al. Nature Communications
- Magnetite/Ceria Nanoparticle Assemblies for Extracorporeal Cleansing of Amyloid‐β in Alzheimer's Disease
- (2019) Dokyoon Kim et al. ADVANCED MATERIALS
- Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
- (2019) Rebecca Parodi-Rullán et al. JOURNAL OF ALZHEIMERS DISEASE
- Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin
- (2019) S. Can Akerman et al. JOURNAL OF ALZHEIMERS DISEASE
- Liver Dysfunction as a Novel Player in Alzheimer’s Progression: Looking Outside the Brain
- (2019) Lisbell D. Estrada et al. Frontiers in Aging Neuroscience
- Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice
- (2019) Chaitanya Chakravarthi Gali et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Peripheral Blood-Derived Microglia-Like Cells Decrease Amyloid-β Burden and Ameliorate Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
- (2019) Eriko Kuroda et al. JOURNAL OF ALZHEIMERS DISEASE
- ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes
- (2019) Varun Rawat et al. JOURNAL OF NEUROSCIENCE
- Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer’s disease
- (2019) Soheil Madadi et al. Cell and Bioscience
- Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease
- (2019) Maya Koronyo-Hamaoui et al. BRAIN
- Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment
- (2019) Yu Ishima et al. IUBMB LIFE
- Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
- (2019) Steven M. Greenberg et al. Nature Reviews Neurology
- Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through reduction of cathepsin B by bis(propyl)-cognitin, a multifunctional dimer
- (2019) Xialin Zuo et al. NEUROPHARMACOLOGY
- The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future
- (2018) Benjamin A. Plog et al. Annual Review of Pathology-Mechanisms of Disease
- The antioxidant xanthorrhizol prevents amyloid-β-induced oxidative modification and inactivation of neprilysin
- (2018) Chol Seung Lim et al. BIOSCIENCE REPORTS
- Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice
- (2018) Kiwami Kidana et al. EMBO Molecular Medicine
- RAGE mediates Aβ accumulation in a mouse model of Alzheimer’s disease via modulation of β- and γ-secretase activity
- (2018) Fang Fang et al. HUMAN MOLECULAR GENETICS
- Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer’s Disease
- (2018) Natalia P. Rocha et al. JOURNAL OF ALZHEIMERS DISEASE
- Gut Microbiota is Altered in Patients with Alzheimer’s Disease
- (2018) Zhen-Qian Zhuang et al. JOURNAL OF ALZHEIMERS DISEASE
- Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model
- (2018) Dario Carradori et al. Nanomedicine-Nanotechnology Biology and Medicine
- Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy
- (2018) Shu-Hui Xin et al. NEUROTOXICITY RESEARCH
- N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease
- (2018) Elena V. Kugaevskaya et al. Scientific Reports
- Deciphering the Astrocyte Reaction in Alzheimer’s Disease
- (2018) Beatriz G. Perez-Nievas et al. Frontiers in Aging Neuroscience
- Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)
- (2018) Michael Burwinkel et al. Acta Neuropathologica Communications
- Dementia, Alzheimer’s Disease, and Mortality after Hemodialysis Initiation
- (2018) Mara A. McAdams-DeMarco et al. Clinical Journal of the American Society of Nephrology
- Blocking the Apolipoprotein E/Amyloid-β Interaction Reduces Fibrillar Vascular Amyloid Deposition and Cerebral Microhemorrhages in TgSwDI Mice
- (2018) Jing Yang et al. JOURNAL OF ALZHEIMERS DISEASE
- Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria
- (2018) Nyosha Alikhani et al. JOURNAL OF ALZHEIMERS DISEASE
- Characterization of Insulin Degrading Enzyme and Other Amyloid-β Degrading Proteases in Human Serum: A Role in Alzheimer's Disease?
- (2018) Zhiheng Liu et al. JOURNAL OF ALZHEIMERS DISEASE
- Decreased Expression of Cathepsin D in Monocytes is Related to the Defective Degradation of Amyloid-β in Alzheimer's Disease
- (2018) Li Tian et al. JOURNAL OF ALZHEIMERS DISEASE
- Alzheimer's Disease-Like Impaired Cognition in Endothelial-Specific Megalin-Null Mice
- (2018) Marcelo Dietrich et al. JOURNAL OF ALZHEIMERS DISEASE
- Neprilysin degrades murine Amyloid-β (Aβ) more efficiently than human Aβ: Further implication for species-specific amyloid accumulation
- (2018) Matthias Becker et al. NEUROSCIENCE LETTERS
- Fatty Acids Compete with Aβ in Binding to Serum Albumin by Quenching Its Conformational Flexibility
- (2018) Cong Guo et al. BIOPHYSICAL JOURNAL
- Oligopeptides Generated by Neprilysin Degradation of β-Amyloid Have the Highest Cu(II) Affinity in the Whole Aβ Family
- (2018) Karolina Bossak-Ahmad et al. INORGANIC CHEMISTRY
- 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease
- (2018) Christian Klein et al. Acta Neuropathologica Communications
- Reduced Cardiovascular Functions in Patients with Alzheimer’s Disease
- (2017) Wang-Sheng Jin et al. JOURNAL OF ALZHEIMERS DISEASE
- Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide
- (2017) Asa Hatami et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies
- (2017) Mitsuru Shinohara et al. JOURNAL OF LIPID RESEARCH
- The Research on the Relationship of RAGE, LRP-1, and Aβ Accumulation in the Hippocampus, Prefrontal Lobe, and Amygdala of STZ-Induced Diabetic Rats
- (2017) Lou-Yan Ma et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- DrosophilaNeprilysin 1 Rescues Memory Deficits Caused by Amyloid-β Peptide
- (2017) Oriane Turrel et al. JOURNAL OF NEUROSCIENCE
- Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition
- (2017) Chia-Chen Liu et al. JOURNAL OF NEUROSCIENCE
- Trans -crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients
- (2017) Roberto Tiribuzi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies
- (2017) X-L Bu et al. MOLECULAR PSYCHIATRY
- A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain
- (2017) Jun Wang et al. Nature Reviews Neurology
- The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy
- (2017) Andrew Bacyinski et al. Frontiers in Neuroanatomy
- APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
- (2017) Hélène-Marie Lanoiselée et al. PLOS MEDICINE
- Efficacy and safety of anti-amyloid-β immunotherapy for Alzheimer's disease: a systematic review and network meta-analysis
- (2017) Jia-Jie Mo et al. Annals of Clinical and Translational Neurology
- The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets
- (2017) Xue-mei Qi et al. Translational Neurodegeneration
- Effects of 4-Hydroxy-Nonenal and Amyloid-β on Expression and Activity of Endothelin Converting Enzyme and Insulin Degrading Enzyme in SH-SY5Y Cells
- (2017) Rui Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- AβPP A713T Mutation in Late Onset Alzheimer's Disease with Cerebrovascular Lesions
- (2017) Livia Bernardi et al. JOURNAL OF ALZHEIMERS DISEASE
- Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein
- (2017) Pietra Candela et al. JOURNAL OF ALZHEIMERS DISEASE
- Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease
- (2016) Ben J. Gu et al. ACTA NEUROPATHOLOGICA
- Patients that have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer’s Disease by Removal of Blood Amyloid
- (2016) Kazuyoshi Sakai et al. JOURNAL OF ALZHEIMERS DISEASE
- Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model
- (2016) Carla M. Yuede et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MMP-9 in translation: from molecule to brain physiology, pathology, and therapy
- (2016) Behnam Vafadari et al. JOURNAL OF NEUROCHEMISTRY
- Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease
- (2016) Rikke Nielsen et al. KIDNEY INTERNATIONAL
- Molecular modeling approach to explore the role of cathepsin B from Hordeum vulgare in the degradation of Aβ peptides
- (2016) Maruti J. Dhanavade et al. Molecular BioSystems
- Association of Plasma β-Amyloid with Cognitive Performance and Decline in Chronic Kidney Disease
- (2016) Janine Gronewold et al. MOLECULAR NEUROBIOLOGY
- Associations Between Hepatic Functions and Plasma Amyloid-Beta Levels—Implications for the Capacity of Liver in Peripheral Amyloid-Beta Clearance
- (2016) Ye-Ran Wang et al. MOLECULAR NEUROBIOLOGY
- Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
- (2016) Sofia Söllvander et al. Molecular Neurodegeneration
- Alzheimer Disease and Its Growing Epidemic
- (2016) Richard A. Hickman et al. NEUROLOGIC CLINICS
- Dementia risk in renal dysfunction
- (2016) Kay Deckers et al. NEUROLOGY
- Incidence of Dementia over Three Decades in the Framingham Heart Study
- (2016) Claudia L. Satizabal et al. NEW ENGLAND JOURNAL OF MEDICINE
- The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function
- (2016) Samuel E. Marsh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?
- (2016) Mobina Alemi et al. Scientific Reports
- Mechanisms of Aβ Clearance and Degradation by Glial Cells
- (2016) Miriam Ries et al. Frontiers in Aging Neuroscience
- Design of Peptide Substrate for Sensitively and Specifically Detecting Two Aβ-Degrading Enzymes: Neprilysin and Angiotensin-Converting Enzyme
- (2016) Po-Ting Chen et al. PLoS One
- Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease
- (2015) Yang Xiang et al. ACTA NEUROPATHOLOGICA
- Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease
- (2015) Yosef Koronyo et al. BRAIN
- Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization
- (2015) Carlos Pomilio et al. HIPPOCAMPUS
- A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
- (2015) Aleksanteri Aspelund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Factors Responsible for Plasma β-Amyloid Accumulation in Chronic Kidney Disease
- (2015) Janine Gronewold et al. MOLECULAR NEUROBIOLOGY
- Repeated intraperitoneal injections of liposomes containing phosphatidic acid and cardiolipin reduce amyloid-β levels in APP/PS1 transgenic mice
- (2015) Lara Ordóñez-Gutiérrez et al. Nanomedicine-Nanotechnology Biology and Medicine
- Structural and functional features of central nervous system lymphatic vessels
- (2015) Antoine Louveau et al. NATURE
- Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
- (2015) Elena Zenaro et al. NATURE MEDICINE
- Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
- (2015) Zhen Zhao et al. NATURE NEUROSCIENCE
- Clearance systems in the brain—implications for Alzheimer disease
- (2015) Jenna M. Tarasoff-Conway et al. Nature Reviews Neurology
- The role of type 2 diabetes in neurodegeneration
- (2015) Giuseppe Verdile et al. NEUROBIOLOGY OF DISEASE
- Sleep-disordered breathing advances cognitive decline in the elderly
- (2015) R. S. Osorio et al. NEUROLOGY
- Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology
- (2015) Kuti Baruch et al. Nature Communications
- Anti-Aβ Autoantibodies in Amyloid Related Imaging Abnormalities (ARIA): Candidate Biomarker for Immunotherapy in Alzheimer’s Disease and Cerebral Amyloid Angiopathy
- (2015) Jacopo C. DiFrancesco et al. Frontiers in Neurology
- Cerebral Amyloid Angiopathy: Emerging Concepts
- (2015) Masahito Yamada Journal of Stroke
- Amyloid-β efflux from the central nervous system into the plasma
- (2014) Kaleigh Filisa Roberts et al. ANNALS OF NEUROLOGY
- Impairment of paravascular clearance pathways in the aging brain
- (2014) Benjamin T. Kress et al. ANNALS OF NEUROLOGY
- Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
- (2014) Mi-Hyang Cho et al. Autophagy
- Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS
- (2014) Biljana Georgievska et al. JOURNAL OF NEUROCHEMISTRY
- Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
- (2014) Edgar Dawkins et al. JOURNAL OF NEUROCHEMISTRY
- Multiple Factors Contribute to the Peripheral Induction of Cerebral -Amyloidosis
- (2014) Y. S. Eisele et al. JOURNAL OF NEUROSCIENCE
- Association Between Serum Amyloid-Beta and Renal Functions: Implications for Roles of Kidney in Amyloid-Beta Clearance
- (2014) Yu-Hui Liu et al. MOLECULAR NEUROBIOLOGY
- Phagocytosis of Microglia in the Central Nervous System Diseases
- (2014) Ruying Fu et al. MOLECULAR NEUROBIOLOGY
- ABCA7 in Alzheimer’s Disease
- (2014) Qing-Fei Zhao et al. MOLECULAR NEUROBIOLOGY
- GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
- (2014) Seonmi Jo et al. NATURE MEDICINE
- Lessons from immunotherapy for Alzheimer disease
- (2014) Yan-Jiang Wang Nature Reviews Neurology
- Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling
- (2014) Hisham Qosa et al. NEUROPHARMACOLOGY
- Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease
- (2014) Teng Jiang et al. NEUROPSYCHOPHARMACOLOGY
- Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
- (2014) Mathew Blurton-Jones et al. Stem Cell Research & Therapy
- Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes
- (2014) J. Scott Miners et al. Frontiers in Aging Neuroscience
- The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy
- (2014) Alan W. J. Morris et al. Frontiers in Aging Neuroscience
- Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease
- (2014) Natalia N. Nalivaeva et al. Frontiers in Aging Neuroscience
- Fine Mapping of the Amyloid β-Protein Binding Site on Myelin Basic Protein
- (2013) AnnMarie E. Kotarba et al. BIOCHEMISTRY
- Amyloid β peptide cleavage by kallikrein 7 attenuates fibril growth and rescues neurons from Aβ-mediated toxicity in vitro
- (2013) Tyler D. Shropshire et al. BIOLOGICAL CHEMISTRY
- Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice
- (2013) Min Hee Park et al. BRAIN RESEARCH
- Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease
- (2013) Zhiyou Cai et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Neuronal Clearance of Amyloid- by Endocytic Receptor LRP1
- (2013) T. Kanekiyo et al. JOURNAL OF NEUROSCIENCE
- P2Y4 Receptor-Mediated Pinocytosis Contributes to Amyloid Beta-Induced Self-Uptake by Microglia
- (2013) H.-q. Li et al. MOLECULAR AND CELLULAR BIOLOGY
- CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
- (2013) Elizabeth M Bradshaw et al. NATURE NEUROSCIENCE
- Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice
- (2013) Panayiota Papadopoulos et al. NEUROBIOLOGY OF AGING
- Proteolytic Degradation of Amyloid -Protein
- (2013) T. Saido et al. Cold Spring Harbor Perspectives in Medicine
- The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease
- (2013) Ayman ElAli et al. Frontiers in Physiology
- PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Toward Engineering of Functional Nanomedicines for Alzheimer’s Disease
- (2012) Davide Brambilla et al. ACS Nano
- APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38
- (2012) Maria Luisa Moro et al. ACTA NEUROPATHOLOGICA
- Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease
- (2012) Sang-Sun Yoon et al. Biomolecules & Therapeutics
- The Pathophysiology and Clinical Presentation of Cerebral Amyloid Angiopathy
- (2012) Eitan Auriel et al. Current Atherosclerosis Reports
- Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice
- (2012) N. F. Fitz et al. JOURNAL OF NEUROSCIENCE
- Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
- (2012) N. Sehgal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system
- (2012) Lin Zheng et al. Translational Neurodegeneration
- Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
- (2011) Cheryl A. Hawkes et al. ACTA NEUROPATHOLOGICA
- Cerebral amyloid angiopathy in the elderly
- (2011) Anand Viswanathan et al. ANNALS OF NEUROLOGY
- Neprilysin Protects against Cerebral Amyloid Angiopathy and Aβ-Induced Degeneration of Cerebrovascular Smooth Muscle Cells
- (2011) James Scott Miners et al. BRAIN PATHOLOGY
- Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes
- (2011) Rea Pihlaja et al. GLIA
- Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease
- (2011) James Scott Miners et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Apolipoprotein E in Alzheimer's disease and other neurological disorders
- (2011) Philip B Verghese et al. LANCET NEUROLOGY
- Neuronal activity regulates the regional vulnerability to amyloid-β deposition
- (2011) Adam W Bero et al. NATURE NEUROSCIENCE
- Mechanism mediating oligomeric Aβ clearance by naïve primary microglia
- (2011) Cheng-Ning Yang et al. NEUROBIOLOGY OF DISEASE
- Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP)in Vitro
- (2010) Mei-Chen Liao et al. BIOCHEMISTRY
- Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain
- (2010) Min-Ju Kim et al. FASEB JOURNAL
- An aminopeptidase fromStreptomycessp. KK565 degrades beta amyloid monomers, oligomers and fibrils
- (2010) Chulbae Yoo et al. FEBS LETTERS
- Astrocytic Aβ1-42 uptake is determined by Aβ-aggregation state and the presence of amyloid-associated proteins
- (2010) Henrietta M. Nielsen et al. GLIA
- N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly
- (2010) Mei-Chen Liao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of microglia in amyloid clearance from the AD brain
- (2010) C. Y. Daniel Lee et al. JOURNAL OF NEURAL TRANSMISSION
- Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain
- (2010) Berislav V. Zlokovic et al. JOURNAL OF NEUROCHEMISTRY
- Trafficking CD11b-Positive Blood Cells Deliver Therapeutic Genes to the Brain of Amyloid-Depositing Transgenic Mice
- (2010) L. Lebson et al. JOURNAL OF NEUROSCIENCE
- Amyloid- Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability
- (2010) I. Allaman et al. JOURNAL OF NEUROSCIENCE
- The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
- (2010) Rita J. Guerreiro et al. NEUROBIOLOGY OF AGING
- Prevalence and Impact of Cerebrovascular Lesions in Alzheimer and Lewy Body Diseases
- (2010) Kurt A. Jellinger Neurodegenerative Diseases
- Peripherally Applied A -Containing Inoculates Induce Cerebral -Amyloidosis
- (2010) Y. S. Eisele et al. SCIENCE
- Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies
- (2009) Tamas Revesz et al. ACTA NEUROPATHOLOGICA
- Endothelin-Converting Enzyme-2 Is Increased in Alzheimer’s Disease and Up-Regulated by Aβ
- (2009) Jennifer C. Palmer et al. AMERICAN JOURNAL OF PATHOLOGY
- Myelin Basic Protein Binds to and Inhibits the Fibrillar Assembly of Aβ42 in Vitro
- (2009) Michael D. Hoos et al. BIOCHEMISTRY
- Human Serum Albumin Inhibits Aβ Fibrillization through a “Monomer-Competitor” Mechanism
- (2009) Julijana Milojevic et al. BIOPHYSICAL JOURNAL
- Cerebral amyloidosis: amyloid subunits, mutants and phenotypes
- (2009) A. Rostagno et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Amyloid-targeted therapeutics in Alzheimer's disease: Use of human albumin in plasma exchange as a novel approach for abeta mobilization
- (2009) M. Boada et al. DRUG NEWS & PERSPECTIVES
- Mitochondria and Alzheimer’s disease: amyloid-β peptide uptake and degradation by the presequence protease, hPreP
- (2009) Nyosha Alikhani et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Degradation of Amyloid β Protein by Purified Myelin Basic Protein
- (2009) Mei-Chen Liao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain
- (2009) Frederico A.C. Azevedo et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide
- (2009) Jean Sevalle et al. JOURNAL OF NEUROCHEMISTRY
- Microglia Mediate the Clearance of Soluble A through Fluid Phase Macropinocytosis
- (2009) S. Mandrekar et al. JOURNAL OF NEUROSCIENCE
- Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
- (2009) Rina Yamin et al. Molecular Neurodegeneration
- Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease
- (2009) Yinxing Liu et al. MOLECULAR THERAPY
- An Overview of APP Processing Enzymes and Products
- (2009) Vivian W. Chow et al. NEUROMOLECULAR MEDICINE
- The Role of Apolipoprotein E in Alzheimer's Disease
- (2009) Jungsu Kim et al. NEURON
- Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
- (2009) F. K. Swirski et al. SCIENCE
- Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease
- (2008) Salim S. El-Amouri et al. AMERICAN JOURNAL OF PATHOLOGY
- SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer' Disease: The Role of the Immune System in Clearance of Aβ from the Brain
- (2008) Delphine Boche et al. BRAIN PATHOLOGY
- SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease
- (2008) James Scott Miners et al. BRAIN PATHOLOGY
- Functional Role of Lipoprotein Receptors in Alzheimers Disease
- (2008) Claus Pietrzik et al. Current Alzheimer Research
- Evidence That CD147 Modulation of β-Amyloid (Aβ) Levels Is Mediated by Extracellular Degradation of Secreted Aβ
- (2008) Kulandaivelu S. Vetrivel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The AβCs of Aβ-cleaving Proteases
- (2008) Malcolm A. Leissring JOURNAL OF BIOLOGICAL CHEMISTRY
- Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
- (2008) M D M Haag et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease
- (2008) Hanjun Guan et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Cognitive Effects of Treating Obstructive Sleep Apnea in Alzheimer's Disease: A Randomized Controlled Study
- (2008) Sonia Ancoli-Israel et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice
- (2008) Niki C Carty et al. MOLECULAR THERAPY
- Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease
- (2008) Binggui Sun et al. NEURON
- Enhanced clearance of A in brain by sustaining the plasmin proteolysis cascade
- (2008) J. S. Jacobsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy
- (2007) J. S. Miners et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
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