标题
Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 15, Pages 8208
出版商
MDPI AG
发表日期
2021-07-31
DOI
10.3390/ijms22158208
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Brain activity of benzoate, a D-amino acid oxidase inhibitor, in patients with mild cognitive impairment in a randomized, double-blind, placebo controlled clinical trial
- (2021) Hsien-Yuan Lane et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology
- (2021) Md. Farhad Hossain et al. AGEING RESEARCH REVIEWS
- International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)
- (2021) Adam D. Farmer et al. Frontiers in Human Neuroscience
- Evaluation of Aducanumab for Alzheimer Disease
- (2021) G. Caleb Alexander et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Selective Secretase Targeting for Alzheimer’s Disease Therapy
- (2021) Alvaro Miranda et al. JOURNAL OF ALZHEIMERS DISEASE
- A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
- (2021) Shifu Xiao et al. Alzheimers Research & Therapy
- Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia
- (2021) Chieh-Hsin Lin et al. JAMA Network Open
- Three FDA advisory panel members resign over approval of Alzheimer’s drug
- (2021) Elisabeth Mahase BMJ-British Medical Journal
- Passive antiamyloid immunotherapy for Alzheimerʼs disease
- (2020) Júlia C. Loureiro et al. CURRENT OPINION IN PSYCHIATRY
- Sodium Oligomannate: First Approval
- (2020) Yahiya Y. Syed DRUGS
- Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
- (2020) Neta Lax et al. Journal of Neuroinflammation
- Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders?
- (2020) Michele Tufano et al. MOLECULES
- Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands
- (2020) Aida Iraji et al. BIOORGANIC CHEMISTRY
- Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease
- (2020) Moonseok Choi et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer’s Disease and Other Neurodegenerative Disorders
- (2020) Sylwia Wójtowicz et al. NEUROCHEMICAL RESEARCH
- A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
- (2020) Min Sung Gee et al. Alzheimers Research & Therapy
- TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
- (2020) Junling Yang et al. Frontiers in Immunology
- Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer’s and Parkinson’s disease therapeutics
- (2020) Therese S. Salameh et al. BIOCHEMICAL PHARMACOLOGY
- Non-invasive vagus nerve stimulation for primary headache: A clinical update
- (2020) Stephen D Silberstein et al. CEPHALALGIA
- Exploring the multimodal role of phytochemicals in the modulation of cellular signaling pathways to combat age-related neurodegeneration
- (2020) Md. Sahab Uddin et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval
- (2020) Martin Tolar et al. Alzheimers Research & Therapy
- Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia
- (2020) Suzanne Craft et al. JAMA Neurology
- Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study
- (2020) Katherine Samaras et al. DIABETES CARE
- Beyond cardiovascular medicine: potential future uses of icosapent ethyl
- (2020) Deepak L Bhatt et al. EUROPEAN HEART JOURNAL SUPPLEMENTS
- STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation
- (2020) Périne Millot et al. IMMUNOLOGY LETTERS
- Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model
- (2020) Juan Jose Fernandez-Valenzuela et al. Scientific Reports
- A phase II randomized trial of sodium oligomannate in Alzheimer’s dementia
- (2020) Tao Wang et al. Alzheimers Research & Therapy
- The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease
- (2020) Ya-Shuo Feng et al. AGEING RESEARCH REVIEWS
- Hippocampal hyperglutamatergic signaling matters: Early targeting glutamate neurotransmission as a preventive strategy in Alzheimer's disease
- (2020) Natalia V. Gulyaeva JOURNAL OF NEUROCHEMISTRY
- The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
- (2020) Ashwinipriyadarshini Megur et al. Nutrients
- New Insights Into Drug Discovery Targeting Tau Protein
- (2020) Yoshiyuki Soeda et al. Frontiers in Molecular Neuroscience
- Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms
- (2020) Katiuscia Pagano et al. Frontiers in Neuroscience
- TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
- (2020) Yongji Zhou et al. Frontiers in Neuroscience
- Vaccination against β-Amyloid as a Strategy for the Prevention of Alzheimer’s Disease
- (2020) Francesca Mantile et al. Biology-Basel
- Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease
- (2019) Darshpreet Kaur et al. INFLAMMOPHARMACOLOGY
- The Role of NMDA Receptors in Alzheimer’s Disease
- (2019) Jinping Liu et al. Frontiers in Neuroscience
- Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease
- (2019) Yoshiyuki Soeda et al. JOURNAL OF ALZHEIMERS DISEASE
- Therapeutic noninvasive brain stimulation in Alzheimerʼs disease and related dementias
- (2019) Stephanie S. Buss et al. CURRENT OPINION IN NEUROLOGY
- Tau immunotherapies for Alzheimer’s disease
- (2019) Justin L. Hoskin et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Do BACE inhibitor failures in Alzheimer’s patients challenge the amyloid hypothesis of the disease?
- (2019) Francesco Panza et al. Expert Review of Neurotherapeutics
- Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease
- (2019) David Henley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease
- (2019) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)
- (2019) Grazia Daniela Femminella et al. Trials
- The Role of N-Methyl-D-Aspartate Receptor Neurotransmission and Precision Medicine in Behavioral and Psychological Symptoms of Dementia
- (2019) Chieh-Hsin Lin et al. Frontiers in Pharmacology
- The associations between behavioral-psychological symptoms of dementia (BPSD) and coping strategy, burden of care and personality style among low-income caregivers of patients with dementia
- (2019) Aishah Diyana Baharudin et al. BMC PUBLIC HEALTH
- Effects of 6-month at-home transcranial direct current stimulation on cognition and cerebral glucose metabolism in Alzheimer's disease
- (2019) Jooyeon Jamie Im et al. Brain Stimulation
- Efficacy and Safety of Glycogen Synthase Kinase 3 Inhibitors for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
- (2019) Shinji Matsunaga et al. JOURNAL OF ALZHEIMERS DISEASE
- High-frequency repetitive transcranial magnetic stimulation combined with cognitive training improves cognitive function and cortical metabolic ratios in Alzheimer’s disease
- (2019) Fengxia Zhang et al. JOURNAL OF NEURAL TRANSMISSION
- The complexity of tau in Alzheimer’s disease
- (2019) Nima N. Naseri et al. NEUROSCIENCE LETTERS
- Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease
- (2019) Chao Zhou et al. Aging-US
- CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
- (2019) Renzo Mancuso et al. BRAIN
- Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
- (2019) Xinyi Wang et al. CELL RESEARCH
- A Systematic Review and Meta-Analysis of rTMS Effects on Cognitive Enhancement in Mild Cognitive Impairment and Alzheimer’s Disease
- (2019) Ying-hui Chou et al. NEUROBIOLOGY OF AGING
- Novel Treatment for the hardest-to-treat Schizophrenia: Dual Activation of NMDA Receptor and Antioxidant
- (2019) Chieh-Hsin Lin et al. CURRENT DRUG TARGETS
- Investigational BACE inhibitors for the treatment of Alzheimer’s disease
- (2019) Bruno P. Imbimbo et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Questions EMERGE as Biogen claims aducanumab turnaround
- (2019) Robert Howard et al. Nature Reviews Neurology
- Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease
- (2019) Alette M. Wessels et al. JAMA Neurology
- Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome
- (2019) Richard M. Tsai et al. JAMA Neurology
- The effects of repetitive transcranial magnetic stimulation in older adults with mild cognitive impairment: a protocol for a randomized, controlled three-arm trial
- (2019) Joy L. Taylor et al. BMC Neurology
- Alzheimer’s disease paper 1: clinical update on epidemiology, pathophysiology and diagnosis
- (2018) Dhamidhu Eratne et al. Australasian Psychiatry
- The Effects of Transcranial Direct Current Stimulation on the Cognitive Functions in Older Adults with Mild Cognitive Impairment: A Pilot Study
- (2018) Pablo Cruz Gonzalez et al. BEHAVIOURAL NEUROLOGY
- Similar clinical improvement and maintenance after rTMS at 5 Hz using a simple vs. complex protocol in Alzheimer's disease
- (2018) R. Alcalá-Lozano et al. Brain Stimulation
- Relationships Between Tau and Glucose Metabolism Reflect Alzheimer’s Disease Pathology in Cognitively Normal Older Adults
- (2018) Jenna N Adams et al. CEREBRAL CORTEX
- The State of US Health, 1990-2016
- (2018) et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation
- (2018) Jeannie-Marie S. Leoutsakos et al. JOURNAL OF ALZHEIMERS DISEASE
- P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model
- (2018) Nicole Reichenbach et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells
- (2018) Cory T. Zumbar et al. JOURNAL OF NEURO-ONCOLOGY
- Intranasal insulin in Alzheimer’s dementia or mild cognitive impairment: a systematic review
- (2018) Konstantinos Ioannis Avgerinos et al. JOURNAL OF NEUROLOGY
- Subthreshold Amyloid Predicts Tau Deposition in Aging
- (2018) Stephanie L. Leal et al. JOURNAL OF NEUROSCIENCE
- The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review
- (2018) Marta Sochocka et al. MOLECULAR NEUROBIOLOGY
- Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
- (2018) Justyna Sosna et al. Molecular Neurodegeneration
- Tau-targeting therapies for Alzheimer disease
- (2018) Erin E. Congdon et al. Nature Reviews Neurology
- Transcranial magnetic stimulation of the precuneus enhances memory and neural activity in prodromal Alzheimer's disease
- (2018) Giacomo Koch et al. NEUROIMAGE
- Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
- (2018) C.Y. Daniel Lee et al. NEURON
- Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease
- (2018) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Repetitive transcranial magnetic stimulation for apathy in mild cognitive impairment: A double-blind, randomized, sham-controlled, cross-over pilot study
- (2018) Prasad R. Padala et al. PSYCHIATRY RESEARCH
- Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy
- (2018) Ghazaleh Kheiri et al. REVIEWS IN THE NEUROSCIENCES
- Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation
- (2018) Ana P. Simões et al. Cell Death & Disease
- Deciphering the Astrocyte Reaction in Alzheimer’s Disease
- (2018) Beatriz G. Perez-Nievas et al. Frontiers in Aging Neuroscience
- Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
- (2018) C. Cheignon et al. Redox Biology
- Brain Stimulation in Alzheimer's Disease
- (2018) Chun-Hung Chang et al. Frontiers in Psychiatry
- Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau
- (2018) Jean-Philippe Courade et al. ACTA NEUROPATHOLOGICA
- GSK3 and Tau: Two Convergence Points in Alzheimer's Disease
- (2018) Felix Hernandez et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis
- (2018) Jared M. Campbell et al. JOURNAL OF ALZHEIMERS DISEASE
- The amyloid hypothesis on trial
- (2018) Simon Makin NATURE
- Imaging the evolution and pathophysiology of Alzheimer disease
- (2018) William Jagust NATURE REVIEWS NEUROSCIENCE
- Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer’s Disease
- (2018) Barbara R. Cardoso et al. Neurotherapeutics
- Predictors of discontinuation, efficacy, and safety of memantine treatment for Alzheimer’s disease: meta-analysis and meta-regression of 18 randomized clinical trials involving 5004 patients
- (2018) Lídia Blanco-Silvente et al. BMC Geriatrics
- Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease
- (2018) Masahir Okamoto et al. Translational Psychiatry
- Neurotheranostics as personalized medicines
- (2018) Bhavesh D. Kevadiya et al. ADVANCED DRUG DELIVERY REVIEWS
- Gabapentin and pregabalin to treat aggressivity in dementia: sa systematic review and illustrative case reports
- (2018) Thitiporn Supasitthumrong et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease
- (2018) Rhonda P. Patrick FASEB JOURNAL
- The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives
- (2018) Cody Wolfe et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Neuroprotective Effects of Gabapentin Against Cerebral Ischemia Reperfusion-Induced Neuronal Autophagic Injury via Regulation of the PI3K/Akt/mTOR Signaling Pathways
- (2018) Bing Chun Yan et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Effects of Transcranial Direct Current Stimulation on Episodic Memory in Amnestic Mild Cognitive Impairment: A Pilot Study
- (2018) Rosa Manenti et al. JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
- Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) Emma Nichols et al. LANCET NEUROLOGY
- Curcumin intervention for cognitive function in different types of people: A systematic review and meta-analysis
- (2018) Li-Na Zhu et al. PHYTOTHERAPY RESEARCH
- FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease
- (2018) Petr Novak et al. Alzheimers Research & Therapy
- Deep brain stimulation: potential for neuroprotection
- (2018) Chris McKinnon et al. Annals of Clinical and Translational Neurology
- A randomized, double-blind, placebo-controlled crossover study of the effects of levetiracetam on cognition, mood, and balance in healthy older adults
- (2017) Mike R. Schoenberg et al. EPILEPSIA
- Discontinuation, Efficacy, and Safety of Cholinesterase Inhibitors for Alzheimer’s Disease: a Meta-Analysis and Meta-Regression of 43 Randomized Clinical Trials Enrolling 16 106 Patients
- (2017) Lídia Blanco-Silvente et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro
- (2017) Jitendra Subhash Rane et al. JOURNAL OF ALZHEIMERS DISEASE
- Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer’s Disease Biomarkers: A Pilot Clinical Trial
- (2017) Suzanne Craft et al. JOURNAL OF ALZHEIMERS DISEASE
- The Mechanisms of Action of Curcumin in Alzheimer’s Disease
- (2017) Mengxi Tang et al. JOURNAL OF ALZHEIMERS DISEASE
- Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial
- (2017) Petr Novak et al. LANCET NEUROLOGY
- Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease
- (2017) Jong Kil Lee et al. MOLECULES
- Alzheimer's disease as oligomeropathy
- (2017) Kenjiro Ono NEUROCHEMISTRY INTERNATIONAL
- Efectividad de la suplementación de ácidos grasos omega-3 en pacientes con enfermedad de Alzheimer: revisión sistemática con metaanálisis
- (2017) F. Araya-Quintanilla et al. NEUROLOGIA
- Prevalencia e incidencia de la enfermedad de Alzheimer en Europa: metaanálisis
- (2017) H. Niu et al. NEUROLOGIA
- Neuroanatomical Characteristics Associated With Response to Deep Brain Stimulation of the Nucleus Basalis of Meynert for Alzheimer's Disease
- (2017) Juan Carlos Baldermann et al. NEUROMODULATION
- A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease
- (2017) Susanne Ostrowitzki et al. Alzheimers Research & Therapy
- Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial
- (2017) Chieh-Hsin Lin et al. BIOLOGICAL PSYCHIATRY
- Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology
- (2016) Adrian Olmos-Alonso et al. BRAIN
- Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging
- (2016) Lorraine Hamelin et al. BRAIN
- Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease
- (2016) Claire L. McDonald et al. BRAIN BEHAVIOR AND IMMUNITY
- Deep Brain Stimulation of the Nucleus Basalis of Meynert in Alzheimer's Dementia: Potential Predictors of Cognitive Change and Results of a Long-Term Follow-Up in Eight Patients
- (2016) K. Hardenacke et al. Brain Stimulation
- Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults
- (2016) Stephanie R. Rainey-Smith et al. BRITISH JOURNAL OF NUTRITION
- A technical guide to tDCS, and related non-invasive brain stimulation tools
- (2016) A.J. Woods et al. CLINICAL NEUROPHYSIOLOGY
- Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease
- (2016) Suzanne M. de la Monte DRUGS
- Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy
- (2016) Francesco Panza et al. Immunotherapy
- A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease
- (2016) Andres M. Lozano et al. JOURNAL OF ALZHEIMERS DISEASE
- A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer’s Disease
- (2016) Charles B. Malpas et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial
- (2016) José A. Luchsinger et al. JOURNAL OF ALZHEIMERS DISEASE
- Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
- (2016) Taylor R. Jay et al. JOURNAL OF NEUROSCIENCE
- Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
- (2016) Serge Gauthier et al. LANCET
- Alzheimer's disease
- (2016) Philip Scheltens et al. LANCET
- Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs
- (2016) José Iglesias et al. MOLECULAR NEUROBIOLOGY
- Levetiracetam as an antiepileptic, neuroprotective, and hyperalgesic drug
- (2016) A Alfaro-Rodríguez et al. NEUROLOGY INDIA
- A comprehensive database of published tDCS clinical trials (2005–2016)
- (2016) Jean-Pascal Lefaucheur NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
- The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß 1-42 oligomers in mice
- (2016) Gian Marco Leggio et al. PHARMACOLOGICAL RESEARCH
- Repetitive transcranial magnetic stimulation improves cognitive function of Alzheimer’s disease patients
- (2016) Junwu Zhao et al. Oncotarget
- Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer’s disease: a randomized, placebo-controlled trial
- (2016) Martin Bystad et al. Alzheimers Research & Therapy
- Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
- (2016) Nicole Maphis et al. Alzheimers Research & Therapy
- In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial
- (2016) Michael Gejl et al. Frontiers in Aging Neuroscience
- Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy
- (2016) Liang Wang et al. JAMA Neurology
- Effects of Transcranial Alternating Current Stimulation on Cognitive Functions in Healthy Young and Older Adults
- (2016) Daria Antonenko et al. NEURAL PLASTICITY
- Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study
- (2015) Hellen Livia Drumond Marra et al. BEHAVIOURAL NEUROLOGY
- Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury
- (2015) Sandy R. Shultz et al. BRAIN
- US Prevalence And Predictors Of Informal Caregiving For Dementia
- (2015) Esther M. Friedman et al. HEALTH AFFAIRS
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance
- (2015) Hilal S. Khalil et al. JOURNAL OF BIOTECHNOLOGY
- Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies
- (2015) Irene Sola et al. JOURNAL OF MEDICINAL CHEMISTRY
- Attenuation of microglial activation in a mouse model of Alzheimer’s disease via NFAT inhibition
- (2015) Lalida Rojanathammanee et al. Journal of Neuroinflammation
- The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases
- (2015) L. Ben Haim et al. JOURNAL OF NEUROSCIENCE
- Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia
- (2015) Joshua F. Zeidner et al. LEUKEMIA RESEARCH
- The Role of Cdk5 in Alzheimer’s Disease
- (2015) Shu-Lei Liu et al. MOLECULAR NEUROBIOLOGY
- p38 MAPK Mediates Glial P2X7R-Neuronal P2Y1R Inhibitory Control of P2X3R Expression in Dorsal Root Ganglion Neurons
- (2015) Yong Chen et al. Molecular Pain
- Tau and neurodegenerative disease: the story so far
- (2015) Khalid Iqbal et al. Nature Reviews Neurology
- Transcutaneous vagus nerve stimulation boosts associative memory in older individuals
- (2015) Heidi I.L. Jacobs et al. NEUROBIOLOGY OF AGING
- Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA
- (2015) Simon C. Dyall Frontiers in Aging Neuroscience
- Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease
- (2015) J. Thomas et al. Biomed Research International
- Targeting Prodromal Alzheimer Disease With Avagacestat
- (2015) Vladimir Coric et al. JAMA Neurology
- NMDA Neurotransmission Dysfunction in Mild Cognitive Impairment and Alzheimer’s Disease
- (2014) Chieh-Hsin Lin et al. CURRENT PHARMACEUTICAL DESIGN
- Targeting the neurophysiology of cognitive systems with transcranial alternating current stimulation
- (2014) Flavio Fröhlich et al. Expert Review of Neurotherapeutics
- Selenium and selenoprotein function in brain disorders
- (2014) Roshan Pillai et al. IUBMB LIFE
- Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice
- (2014) Arnaud François et al. Journal of Neuroinflammation
- Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
- (2014) Katherine HM Cox et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer's disease: A pilot study
- (2014) Ilona Eliasova et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia
- (2014) J Kuhn et al. MOLECULAR PSYCHIATRY
- A Double-Blind Randomized Clinical Trial on the Efficacy of Cortical Direct Current Stimulation for the Treatment of Alzheimer’s Disease
- (2014) Eman M. Khedr et al. Frontiers in Aging Neuroscience
- Brain Stimulation for Combating Alzheimer’s Disease
- (2014) Niels Hansen Frontiers in Neurology
- Benzoate, a D-Amino Acid Oxidase Inhibitor, for the Treatment of Early-Phase Alzheimer Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
- (2013) Chieh-Hsin Lin et al. BIOLOGICAL PSYCHIATRY
- In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease
- (2013) William C. Kreisl et al. BRAIN
- Effects of a Non-focal Plasticity Protocol on Apathy in Moderate Alzheimer's Disease: A Randomized, Double-blind, Sham-controlled Trial
- (2013) Claudia Kimie Suemoto et al. Brain Stimulation
- Modulation of the conformational state of the SV2A protein by an allosteric mechanism as evidenced by ligand binding assays
- (2013) V Daniels et al. BRITISH JOURNAL OF PHARMACOLOGY
- Microdose Lithium Treatment Stabilized Cognitive Impairment in Patients with Alzheimer’s Disease
- (2013) Marielza Andrade Nunes et al. Current Alzheimer Research
- A Double-Blind, Placebo-Controlled, Ascending-Dose, Randomized Study to Evaluate the Safety, Tolerability and Effects on Cognition of AL-108 after 12 Weeks of Intranasal Administration in Subjects with Mild Cognitive Impairment
- (2013) Bruce H. Morimoto et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Microglial Phenotype Is Regulated by Activity of the Transcription Factor, NFAT (Nuclear Factor of Activated T Cells)
- (2013) K. Nagamoto-Combs et al. JOURNAL OF NEUROSCIENCE
- Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
- (2013) L. E. Hebert et al. NEUROLOGY
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy
- (2013) Clara Theunis et al. PLoS One
- Davunetide: a review of safety and efficacy data with a focus on neurodegenerative diseases
- (2013) Bruce H Morimoto et al. Expert Review of Clinical Pharmacology
- NMDA Neurotransmission Dysfunction in Behavioral and Psychological Symptoms of Alzheimer's Disease
- (2012) Yu-Jhen Huang et al. Current Neuropharmacology
- Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex
- (2012) Patrizia Turriziani et al. Frontiers in Human Neuroscience
- Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer’s disease: a randomized, double-blind study
- (2012) Jose M. Rabey et al. JOURNAL OF NEURAL TRANSMISSION
- Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
- (2012) Peter T. Nelson et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease
- (2012) E. Hudry et al. JOURNAL OF NEUROSCIENCE
- Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027
- (2012) D. M. Barten et al. JOURNAL OF NEUROSCIENCE
- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
- (2012) B. Zhang et al. JOURNAL OF NEUROSCIENCE
- TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells
- (2012) D. P. Fitzgerald et al. MOLECULAR CANCER THERAPEUTICS
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Effects of omega-3 fatty acids on cognitive performance: a meta-analysis
- (2012) Graham Mazereeuw et al. NEUROBIOLOGY OF AGING
- Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life
- (2012) Danielle Swanson et al. Advances in Nutrition
- Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study
- (2012) John M Ringman et al. Alzheimers Research & Therapy
- Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease
- (2011) Qin Nie et al. ACTA PHARMACOLOGICA SINICA
- Prolonged visual memory enhancement after direct current stimulation in Alzheimer's disease
- (2011) Paulo Sergio Boggio et al. Brain Stimulation
- NAP (Davunetide) Provides Functional and Structural Neuroprotection
- (2011) Illana Gozes CURRENT PHARMACEUTICAL DESIGN
- Microtubules (tau) as an Emerging Therapeutic Target: NAP (Davunetide)
- (2011) Illana Gozes CURRENT PHARMACEUTICAL DESIGN
- Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer’s dementia
- (2011) Mohamed A. Ahmed et al. JOURNAL OF NEUROLOGY
- Alzheimer's Disease: The Challenge of the Second Century
- (2011) D. M. Holtzman et al. Science Translational Medicine
- The cognitive impact of antiepileptic drugs
- (2011) Clare M. Eddy et al. Therapeutic Advances in Neurological Disorders
- A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
- (2010) Adrian W. Laxton et al. ANNALS OF NEUROLOGY
- Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease
- (2010) Joseph F. Quinn et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Improved language performance in Alzheimer disease following brain stimulation
- (2010) M. Cotelli et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Addressing Alzheimers Disease Tangles: From NAP to AL-108
- (2009) Illana Gozes et al. Current Alzheimer Research
- Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial
- (2009) Robert C. Green JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease
- (2009) Larry Baum et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease
- (2009) Tomohiko Sato et al. NEUROBIOLOGY OF AGING
- IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase
- (2009) Laura L. Dugan et al. PLoS One
- Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease
- (2008) P S Boggio et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid 1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease
- (2008) K. L. Richard et al. JOURNAL OF NEUROSCIENCE
- Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
- (2008) Lars Lannfelt et al. LANCET NEUROLOGY
- Transcranial direct current stimulation improves recognition memory in Alzheimer disease
- (2008) R. Ferrucci et al. NEUROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now