Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Interference from Heterophilic Antibodies in Amyloid-β Oligomer ELISAs

(2017) Dag Sehlin et al.   JOURNAL OF ALZHEIMERS DISEASE

Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification

(2015) Camilla Lööv et al.   GLIA

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

(2015) Timo Jan Oberstein et al.   NEUROBIOLOGY OF DISEASE

When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

(2014) Evangelina Avila-Muñoz et al.   AGEING RESEARCH REVIEWS

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Enhancing Astrocytic Lysosome Biogenesis Facilitates A  Clearance and Attenuates Amyloid Plaque Pathogenesis

(2014) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

A Sensitive A  Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid

(2014) M. J. Savage et al.   JOURNAL OF NEUROSCIENCE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease

(2013) Mikko Hölttä et al.   PLoS One

A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid

(2013) Adrianna Z. Herskovits et al.   PLoS One

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome

(2012) Line De Kimpe et al.   AGE

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

(2012) Jacob M. Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

(2012) Raasay S. Jones et al.   Journal of Neuroimmune Pharmacology

Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of  -Amyloid

(2012) S. Nath et al.   JOURNAL OF NEUROSCIENCE

Large Aggregates Are the Major Soluble Aβ Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

(2012) Dag Sehlin et al.   PLoS One

Engulfing Astrocytes Protect Neurons from Contact-Induced Apoptosis following Injury

(2012) Camilla Lööv et al.   PLoS One

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

(2012) C. Di Malta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

(2012) Igor Klyubin et al.   Molecular Brain

Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease

(2011) Anna Lord et al.   AMERICAN JOURNAL OF PATHOLOGY

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging

(2010) Daijun Ling et al.   ACTA NEUROPATHOLOGICA

Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor

(2010) Jennifer D. Sokolowski et al.   BRAIN BEHAVIOR AND IMMUNITY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients

(2010) Hiroaki Fukumoto et al.   FASEB JOURNAL

Regulation of synaptic connectivity by glia

(2010) Cagla Eroglu et al.   NATURE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages

(2009) D. Liebl et al.   JOURNAL OF CELL SCIENCE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Age-dependent increase in lysosome-associated membrane protein 1 and early-onset behavioral deficits in APPSL transgenic mouse model of Alzheimer's disease

(2009) Tetsuya Hashimoto et al.   NEUROSCIENCE LETTERS

Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila

(2009) Daijun Ling et al.   PLoS One

Potency and Fate Specification in CNS Stem Cell Populations In Vitro

(2008) Rea Ravin et al.   Cell Stem Cell

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

A highly insoluble state of Aβ similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

(2008) Ola Philipson et al.   NEUROBIOLOGY OF AGING

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

(2007) John et al.   Frontiers in Bioscience-Landmark