Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight

(2019) Taro Bannai et al.   Scientific Reports

Systematic and standardized comparison of reported Amyloid-β receptors for sufficiency, affinity, and Alzheimer’s disease relevance

(2019) Levi M. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

(2019) Yu Yamazaki et al.   BRAIN

Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia

(2019) Michael A. Sugarman et al.   Alzheimers & Dementia

Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice

(2018) Stefano Tarantini et al.   AGING CELL

Carbonic anhydrase inhibition selectively prevents amyloid β neurovascular mitochondrial toxicity

(2018) María E. Solesio et al.   AGING CELL

Concomitant vascular and neurodegenerative pathologies double the risk of dementia

(2018) Mahmoud Reza Azarpazhooh et al.   Alzheimers & Dementia

Aβ 1-42 induces cell damage via RAGE-dependent endoplasmic reticulum stress in bEnd.3 cells

(2018) Wenjing Chen et al.   EXPERIMENTAL CELL RESEARCH

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy

(2018) M. MacGregor Sharp et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diagnosis of Cerebral Amyloid Angiopathy

(2018) Steven M. Greenberg et al.   STROKE

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

(2018) Fernando Bartolome et al.   Alzheimers Research & Therapy

Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link

(2018) Jaime Ramos-Cejudo et al.   EBioMedicine

Cerebral Microvascular Rather than Parenchymal Amyloid-β Protein Pathology Promotes Early Cognitive Impairment in Transgenic Mice

(2018) Wenjin Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Selective Vulnerability of Synapses and Synaptic Mitochondria in the Hippocampal CA1 Region of the Tg2576 Mouse Model of Alzheimer's Disease

(2018) Marta Balietti et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloidosis Associated with Cerebral Amyloid Angiopathy: Cell Signaling Pathways Elicited in Cerebral Endothelial Cells

(2018) Jorge Ghiso et al.   JOURNAL OF ALZHEIMERS DISEASE

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice

(2018) Nora E. Gray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Mitochondria in Developmental and Adult Neurogenesis

(2018) Macarena S. Arrázola et al.   NEUROTOXICITY RESEARCH

VEGF receptor-1 modulates amyloid β 1-42 oligomer-induced senescence in brain endothelial cells

(2018) Ramcharan Singh Angom et al.   FASEB JOURNAL

Targeting hippocampal adult neurogenesis using transcription factors to reduce Alzheimer's disease-associated memory impairments

(2018) Robin F. Dard et al.   HIPPOCAMPUS

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis

(2017) Mireille Khacho et al.   HUMAN MOLECULAR GENETICS

Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide

(2017) Asa Hatami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating β/γ-Secretases

(2017) Zhiyou Cai et al.   NEUROCHEMICAL RESEARCH

APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

(2017) Hélène-Marie Lanoiselée et al.   PLOS MEDICINE

Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy

(2017) Elisabetta Lauretti et al.   Annals of Clinical and Translational Neurology

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease

(2017) Renato X. Santos et al.   JOURNAL OF ALZHEIMERS DISEASE

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Vascular contributions to cognitive impairment and dementia (VCID)

(2016) M. Paul Murphy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

(2016) Abby Keable et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against Alzheimer's Disease

(2016) T.C. Bernardo et al.   BRAIN PATHOLOGY

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Lutein protects against β-amyloid peptide-induced oxidative stress in cerebrovascular endothelial cells through modulation of Nrf-2 and NF-κb

(2016) Tao Liu et al.   CELL BIOLOGY AND TOXICOLOGY

The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment

(2016) Osigbemhe Iyalomhe et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline

(2016) Roderick A. Corriveau et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Efficacy and Safety of Crocus sativus L. in Patients with Mild Cognitive Impairment: One Year Single-Blind Randomized, with Parallel Groups, Clinical Trial

(2016) Magda Tsolaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteomic differences in brain vessels of Alzheimer’s disease mice: Normalization by PPARγ agonist pioglitazone

(2016) AmanPreet Badhwar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure

(2016) Heather M. Wilkins et al.   JOURNAL OF NEUROCHEMISTRY

Reduction in cardiolipin decreases mitochondrial spare respiratory capacity and increases glucose transport into and across human brain cerebral microvascular endothelial cells

(2016) Hieu M. Nguyen et al.   JOURNAL OF NEUROCHEMISTRY

Traumatic brain injury and age at onset of cognitive impairment in older adults

(2016) Wei Li et al.   JOURNAL OF NEUROLOGY

Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity

(2016) Biuse Guivernau et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain

(2016) Silvia Fossati et al.   NEUROBIOLOGY OF DISEASE

Alzheimer Disease and Its Growing Epidemic

(2016) Richard A. Hickman et al.   NEUROLOGIC CLINICS

Hippocampal neurogenesis: Learning to remember

(2016) Orly Lazarov et al.   PROGRESS IN NEUROBIOLOGY

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

(2016) Sara Danuta Petersson et al.   Advances in Nutrition

Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease

(2016) Simona Magi et al.   Biomed Research International

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease

(2015) Katherine J. Bangen et al.   Alzheimers & Dementia

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Toxic species in amyloid disorders: Oligomers or mature fibrils

(2015) Vibha Taneja et al.   Annals of Indian Academy of Neurology

Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer’s DiseaseNovelty and Significance

(2015) Anna Kruyer et al.   HYPERTENSION

Acute Exercise Improves Prefrontal Cortex but not Hippocampal Function in Healthy Adults

(2015) Julia C. Basso et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

(2015) Xing-Lin Tan et al.   Molecular Neurodegeneration

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

(2015) Byung Hee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Mitochondrial Manipulation and the Quest for Alzheimer's Treatments

(2015) Russell H. Swerdlow   EBioMedicine

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

(2015) Liang Zhang et al.   EBioMedicine

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

(2014) Ana Catarina Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Cerebral Oxygenation in Patients With OSA

(2014) Silvia Ulrich et al.   CHEST

Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis

(2014) Heather M. Wilkins et al.   HUMAN MOLECULAR GENETICS

Challenges of multimorbidity of the aging brain: a critical update

(2014) Kurt A. Jellinger et al.   JOURNAL OF NEURAL TRANSMISSION

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

(2014) Ana Catarina R. G. Fonseca et al.   MOLECULAR NEUROBIOLOGY

Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation

(2014) Lezi E et al.   NEUROBIOLOGY OF AGING

Exercise-Induced Neuroprotection of Hippocampus in APP/PS1 Transgenic Mice via Upregulation of Mitochondrial 8-Oxoguanine DNA Glycosylase

(2014) Hai Bo et al.   Oxidative Medicine and Cellular Longevity

Regulation and Function of Adult Neurogenesis: From Genes to Cognition

(2014) James B. Aimone et al.   PHYSIOLOGICAL REVIEWS

The Receptor for Advanced Glycation End-Products (RAGE) Is Only Present in Mammals, and Belongs to a Family of Cell Adhesion Molecules (CAMs)

(2014) Luca Sessa et al.   PLoS One

Coenzyme Q10 Protects Human Endothelial Cells from β-Amyloid Uptake and Oxidative Stress-Induced Injury

(2014) Mario Durán-Prado et al.   PLoS One

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

(2014) Laibaik Park et al.   STROKE

The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction

(2014) L. Park et al.   Nature Communications

Reconsidering hippocampal neurogenesis in Alzheimer's disease

(2014) Alonso Martinez-Canabal   Frontiers in Neuroscience

Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

(2013) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans

(2013) María-Jesús Oliveras-López et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Depolarization of Mitochondria in Endothelial Cells Promotes Cerebral Artery Vasodilation by Activation of Nitric Oxide Synthase

(2013) Prasad V.G. Katakam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23Iowa mutation

(2013) Silvia Fossati et al.   BIOCHEMICAL JOURNAL

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mediterranean Diet, Cognitive Function, and Dementia

(2013) Ilianna Lourida et al.   EPIDEMIOLOGY

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial aldehyde dehydrogenase-2 activation prevents  -amyloid-induced endothelial cell dysfunction and restores angiogenesis

(2013) R. Solito et al.   JOURNAL OF CELL SCIENCE

Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition

(2013) Diewertje I Bink et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology

(2013) Susan A. Austin et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

(2012) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid-β Peptide Binds to Cytochrome C Oxidase Subunit 1

(2012) Luis Fernando Hernandez-Zimbron et al.   PLoS One

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1 -dependent function

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer’s Aβ

(2012) S Fossati et al.   Cell Death & Disease

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

Cerebral amyloid angiopathy in the elderly

(2011) Anand Viswanathan et al.   ANNALS OF NEUROLOGY

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Permeabilization of the Mitochondrial Outer Membrane by Bax/Truncated Bid (tBid) Proteins as Sensitized by Cardiolipin Hydroperoxide Translocation

(2011) Witold Korytowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral Amyloid Angiopathy: A Systematic Review

(2011) Alessandro Biffi et al.   Journal of Clinical Neurology

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Apigenin Isolated from the Medicinal Plant Elsholtzia rugulosa Prevents β-Amyloid 25–35-Induces Toxicity in Rat Cerebral Microvascular Endothelial Cells

(2011) Le Zhao et al.   MOLECULES

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Insights into Caspase-Mediated Apoptotic Pathways Induced by Amyloid-ß in Cerebral Microvascular Endothelial Cells

(2011) Silvia Fossati et al.   Neurodegenerative Diseases

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

(2011) J. Li et al.   NEUROLOGY

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Prevalence and severity of cerebral amyloid angiopathy: a population-based study on very elderly Finns (Vantaa 85+)

(2011) M. Tanskanen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

(2011) Merina Varghese et al.   Translational Neuroscience

Vascular pathology in the aged human brain

(2010) Lea Tenenholz Grinberg et al.   ACTA NEUROPATHOLOGICA

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

(2010) Costantino Iadecola   ACTA NEUROPATHOLOGICA

Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo

(2010) Ping-Pin Zheng et al.   ANNALS OF NEUROLOGY

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

(2010) A. A. Gouw et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Mitochondrial Protection Attenuates Inflammation-Induced Impairment of Neurogenesis In Vitro and In Vivo

(2010) L. A. Voloboueva et al.   JOURNAL OF NEUROSCIENCE

Capillary CAA and perivascular Aβ-deposition: Two distinct features of Alzheimer's disease pathology

(2010) Johannes Attems et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

(2010) Rita J. Guerreiro et al.   NEUROBIOLOGY OF AGING

Review: Cerebral microvascular pathology in ageing and neurodegeneration

(2010) W. R. Brown et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mitochondrial Superoxide Contributes to Blood Flow and Axonal Transport Deficits in the Tg2576 Mouse Model of Alzheimer's Disease

(2010) Cynthia A. Massaad et al.   PLoS One

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

(2009) Tamas Revesz et al.   ACTA NEUROPATHOLOGICA

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Chronic cerebral hypoperfusion accelerates amyloid β deposition in APPSwInd transgenic mice

(2009) Hiroshi Kitaguchi et al.   BRAIN RESEARCH

Cerebral amyloidosis: amyloid subunits, mutants and phenotypes

(2009) A. Rostagno et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tauroursodeoxycholic acid prevents E22Q Alzheimer’s Aβ toxicity in human cerebral endothelial cells

(2009) R. J. S. Viana et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls

(2009) S. Fossati et al.   FASEB JOURNAL

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

(2009) Sónia C. Correia et al.   JOURNAL OF NEUROCHEMISTRY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Significant negative correlations between capillary expressed eNOS and Alzheimer lesion burden

(2009) Brian Jeynes et al.   NEUROSCIENCE LETTERS

Long-term incubation with β-amyloid peptides impairs endothelium-dependent vasodilatation in isolated rat basilar artery

(2009) Mariangela Chisari et al.   PHARMACOLOGICAL RESEARCH

Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid β Protein

(2009) Karunya K. Kandimalla et al.   PLoS One

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

(2009) Shahin Akhondzadeh et al.   PSYCHOPHARMACOLOGY

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Signaling by death receptors in the nervous system

(2008) Georg Haase et al.   CURRENT OPINION IN NEUROBIOLOGY

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Centella asiaticaextract selectively decreases amyloidβlevels in hippocampus of Alzheimer's disease animal model

(2008) Muralikrishnan Dhanasekaran et al.   PHYTOTHERAPY RESEARCH

Understanding White Matter Disease: Imaging-Pathological Correlations in Vascular Cognitive Impairment

(2008) S. Black et al.   STROKE