Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice

标题
Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice
作者
关键词
Alzheimer's disease, Amyloid-β peptides, Low-density lipoprotein receptor-related protein-1, Insulin receptor-beta, Insulin signaling, Blood-brain barrier, Endothelial cells, Autophagy-lysosomal pathway
出版物
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 99, Issue -, Pages 103390
出版商
Elsevier BV
发表日期
2019-07-03
DOI
10.1016/j.mcn.2019.103390

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