The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons

Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms

(2023) Makaía M. Papasergi-Scott et al.   STRUCTURE

The Joubert–Meckel–Nephronophthisis Spectrum of Ciliopathies

(2022) Julie C. Van De Weghe et al.   Annual Review of Genomics and Human Genetics

Chemosensory signal transduction in Caenorhabditis elegans

(2021) Denise M Ferkey et al.   GENETICS

Molecular topography of an entire nervous system

(2021) Seth R. Taylor et al.   CELL

Sensory cilia act as a specialized venue for regulated extracellular vesicle biogenesis and signaling

(2021) Juan Wang et al.   CURRENT BIOLOGY

Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons

(2021) Adria Razzauti et al.   eLife

Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

(2020) Levi J. McClelland et al.   Nature Communications

Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms

(2020) Alpay Burak Seven et al.   Cell Reports

Cellular signalling by primary cilia in development, organ function and disease

(2019) Zeinab Anvarian et al.   Nature Reviews Nephrology

A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans

(2019) Ashish Kumar Maurya et al.   CURRENT BIOLOGY

Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A

(2019) Baisen Zeng et al.   STRUCTURE

Structural underpinnings of Ric8A function as a G-protein α-subunit chaperone and guanine-nucleotide exchange factor

(2019) Dhiraj Srivastava et al.   Nature Communications

The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition

(2019) Danielle DiTirro et al.   eLife

Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange

(2018) Makaía M. Papasergi-Scott et al.   Science Signaling

Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange

(2018) Makaía M. Papasergi-Scott et al.   Science Signaling

Centrioles initiate cilia assembly but are dispensable for maturation and maintenance inC. elegans

(2017) Daniel Serwas et al.   JOURNAL OF CELL BIOLOGY

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans

(2017) Inna V Nechipurenko et al.   eLife

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis

(2016) Inna V. Nechipurenko et al.   DEVELOPMENTAL CELL

Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

(2016) Ravi Kant et al.   eLife

Recruitment of β-arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization

(2015) Jill A. Green et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis for nucleotide exchange in heterotrimeric G proteins

(2015) R. O. Dror et al.   SCIENCE

A Circuit for Gradient Climbing in C. elegans Chemotaxis

(2015) Johannes Larsch et al.   Cell Reports

The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking

(2015) Ruxandra Bachmann-Gagescu et al.   PLoS Genetics

C. elegans Ciliated Sensory Neurons Release Extracellular Vesicles that Function in Animal Communication

(2014) Juan Wang et al.   CURRENT BIOLOGY

Diverse Cell Type-Specific Mechanisms Localize G Protein-Coupled Receptors to Caenorhabditis elegans Sensory Cilia

(2014) Andrea G. Brear et al.   GENETICS

The nphp-2 and arl-13 Genetic Modules Interact to Regulate Ciliogenesis and Ciliary Microtubule Patterning in C. elegans

(2014) Simon R. F. Warburton-Pitt et al.   PLoS Genetics

A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans

(2014) David B Doroquez et al.   eLife

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route

(2013) Samantha Papal et al.   HUMAN MOLECULAR GENETICS

Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans

(2013) M. Wojtyniak et al.   JOURNAL OF CELL SCIENCE

Arborization of Dendrites by Developing Neocortical Neurons Is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase

(2013) S. M. Guadiana et al.   JOURNAL OF NEUROSCIENCE

Drosophila Ric-8 interacts with the Gα12/13 subunit, Concertina, during activation of the Folded gastrulation pathway

(2013) Kimberly A. Peters et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein   subunits

(2013) P. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ciliopathies: a transitional model into systems biology of human genetic disease

(2012) Erica E Davis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Structural Domains Required forCaenorhabditis elegansG Protein-coupled Receptor Kinase 2 (GRK-2) Functionin Vivo

(2012) Jordan F. Wood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the G-protein Regulatory-GαiSignaling Complex by Nonreceptor Guanine Nucleotide Exchange Factors

(2012) Sukru Sadik Oner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Forms of Learning following Training to a Single Odorant in Caenorhabditis elegans AWC Neurons

(2012) S. Pereira et al.   JOURNAL OF NEUROSCIENCE

Non-canonical signaling and localizations of heterotrimeric G proteins

(2011) Thamara Hewavitharana et al.   CELLULAR SIGNALLING

RIC8 Is a Guanine-Nucleotide Exchange Factor for Gα Subunits That Regulates Growth and Development inNeurospora crassa

(2011) Sara J. Wright et al.   GENETICS

Ric-8B Is a GTP-dependent G Protein αsGuanine Nucleotide Exchange Factor

(2011) PuiYee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

AGS-3 Alters Caenorhabditis elegans Behavior after Food Deprivation via RIC-8 Activation of the Neural G Protein G o

(2011) C. Hofler et al.   JOURNAL OF NEUROSCIENCE

The Type 3 Adenylyl Cyclase Is Required for Novel Object Learning and Extinction of Contextual Memory: Role of cAMP Signaling in Primary Cilia

(2011) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

The Nucleotide Exchange Factor Ric-8A Is a Chaperone for the Conformationally Dynamic Nucleotide-Free State of Gαi1

(2011) Celestine J. Thomas et al.   PLoS One

Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein   Subunit Membrane Association

(2011) M. Gabay et al.   Science Signaling

Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

(2010) Tatiana Y. Besschetnova et al.   CURRENT BIOLOGY

The HMX/NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans

(2010) K. Kim et al.   DEVELOPMENT

Regulation of the AGS3·GαiSignaling Complex by a Seven-transmembrane Span Receptor

(2010) Sukru Sadik Oner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport inCaenorhabditis elegans

(2010) Sebiha Cevik et al.   JOURNAL OF CELL BIOLOGY

Ric-8A and Gi  Recruit LGN, NuMA, and Dynein to the Cell Cortex To Help Orient the Mitotic Spindle

(2010) G. E. Woodard et al.   MOLECULAR AND CELLULAR BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development

(2010) Christine Insinna et al.   Neural Development

Spatial Distribution of Calcium-Gated Chloride Channels in Olfactory Cilia

(2010) Donald A. French et al.   PLoS One

Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity

(2010) N. A. Lambert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making sense of cilia in disease: The human ciliopathies

(2009) Kate Baker et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

(2009) Jantje M. Gerdes et al.   CELL

GIV is a nonreceptor GEF for G i with a unique motif that regulates Akt signaling

(2009) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling

(2009) Claire Fenech   Frontiers in Cellular Neuroscience

Regulators of AWC-Mediated Olfactory Plasticity in Caenorhabditis elegans

(2009) Damien M. O'Halloran et al.   PLoS Genetics

Sensory Signaling-Dependent Remodeling of Olfactory Cilia Architecture in C. elegans

(2008) Saikat Mukhopadhyay et al.   DEVELOPMENTAL CELL

Ric-8A Catalyzes Guanine Nucleotide Exchange on Gαi1Bound to the GPR/GoLoco Exchange Inhibitor AGS3

(2008) Celestine J. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region

(2008) D. Shiba et al.   JOURNAL OF CELL SCIENCE

Visualization of protein interactions in living Caenorhabditis elegans using bimolecular fluorescence complementation analysis

(2008) Y John Shyu et al.   Nature Protocols

Nucleus accumbens AGS3 expression drives ethanol seeking through G  

(2008) M. S. Bowers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA