标题
Cellular signalling by primary cilia in development, organ function and disease
作者
关键词
-
出版物
Nature Reviews Nephrology
Volume 15, Issue 4, Pages 199-219
出版商
Springer Nature
发表日期
2019-02-07
DOI
10.1038/s41581-019-0116-9
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition
- (2018) Sang Jun Han et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Structural Basis of Smoothened Activation in Hedgehog Signaling
- (2018) Pengxiang Huang et al. CELL
- A highlight on Sonic hedgehog pathway
- (2018) Gabriela Basile Carballo et al. Cell Communication and Signaling
- Primary cilia proteins: ciliary and extraciliary sites and functions
- (2018) Kiet Hua et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
- (2018) Thomas Rosengren et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The molecular machines that traffic signaling receptors into and out of cilia
- (2018) Maxence V Nachury CURRENT OPINION IN CELL BIOLOGY
- Endosome maturation factors Rabenosyn‐5/VPS45 and caveolin‐1 regulate ciliary membrane and polycystin‐2 homeostasis
- (2018) Noémie Scheidel et al. EMBO JOURNAL
- Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
- (2018) Stine Kjaer Morthorst et al. FEBS Journal
- Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies
- (2018) Michaela Kunova Bosakova et al. HUMAN MOLECULAR GENETICS
- Interaction of heterotrimeric kinesin-II with IFT-B–connecting tetramer is crucial for ciliogenesis
- (2018) Teruki Funabashi et al. JOURNAL OF CELL BIOLOGY
- Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression
- (2018) Anne-Clémence Vion et al. JOURNAL OF CELL BIOLOGY
- BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone
- (2018) Fan Ye et al. JOURNAL OF CELL BIOLOGY
- Intraflagellar transport is deeply integrated in hedgehog signaling
- (2018) Thibaut Eguether et al. MOLECULAR BIOLOGY OF THE CELL
- Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity
- (2018) Jacqueline E. Siljee et al. NATURE GENETICS
- Structure and dynamics of GPCR signaling complexes
- (2018) Daniel Hilger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis for the recognition of Sonic Hedgehog by human Patched1
- (2018) Xin Gong et al. SCIENCE
- G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
- (2018) Ganesh V. Pusapati et al. Science Signaling
- Subcellular Organization of GPCR Signaling
- (2018) Kelsie Eichel et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Structure and dynamics of GPCR signaling complexes
- (2018) Daniel Hilger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
- (2018) K. Koefoed et al. Scientific Reports
- Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis
- (2018) Issei S. Shimada et al. Cell Reports
- Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells
- (2018) Helen Louise May-Simera et al. Cell Reports
- CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium
- (2018) Maren Mönnich et al. Cell Reports
- Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
- (2018) Xiaowen Liu et al. eLife
- G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
- (2018) Ganesh V. Pusapati et al. Science Signaling
- Primary Cilia as a Signaling Platform for Control of Energy Metabolism
- (2018) Do Kyeong Song et al. Diabetes & Metabolism Journal
- Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly
- (2018) Yinwen Liang et al. CURRENT BIOLOGY
- The complexity of the cilium: spatiotemporal diversity of an ancient organelle
- (2018) Westley Heydeck et al. CURRENT OPINION IN CELL BIOLOGY
- Reconstitution reveals motor activation for intraflagellar transport
- (2018) Mohamed A. A. Mohamed et al. NATURE
- Structures of human Patched and its complex with native palmitoylated sonic hedgehog
- (2018) Xiaofeng Qi et al. NATURE
- Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia
- (2018) Lan Ho Wei et al. PLoS One
- Structure of the human PKD1-PKD2 complex
- (2018) Qiang Su et al. SCIENCE
- Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched
- (2018) Yunxiao Zhang et al. CELL
- A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice
- (2018) Matthew J. Ford et al. DEVELOPMENTAL CELL
- Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery
- (2018) Jenna L. Wingfield et al. Essays in Biochemistry
- The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia
- (2018) Mareike A. Jordan et al. NATURE CELL BIOLOGY
- Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery
- (2017) Bram Prevo et al. FEBS Journal
- Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications
- (2017) Zoltan Szucs et al. Future Oncology
- Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia
- (2017) Ludovic Martin et al. HUMAN MOLECULAR GENETICS
- Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis
- (2017) Mariko Takahara et al. HUMAN MOLECULAR GENETICS
- Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins
- (2017) Hemant B. Badgandi et al. JOURNAL OF CELL BIOLOGY
- IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases
- (2017) Fabian Marc Schmid et al. JOURNAL OF CELL BIOLOGY
- Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis
- (2017) C.-H. Heldin et al. JOURNAL OF INTERNAL MEDICINE
- TGF-β1 impairs mechanosensation of human osteoblasts via HDAC6-mediated shortening and distortion of primary cilia
- (2017) Sabrina Ehnert et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors
- (2017) Tomoaki Hirano et al. MOLECULAR BIOLOGY OF THE CELL
- Trends in GPCR drug discovery: new agents, targets and indications
- (2017) Alexander S. Hauser et al. NATURE REVIEWS DRUG DISCOVERY
- Genes and molecular pathways underpinning ciliopathies
- (2017) Jeremy F. Reiter et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements
- (2017) Katerina Toropova et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease
- (2017) Vicente E. Torres et al. NEW ENGLAND JOURNAL OF MEDICINE
- GPCRdb in 2018: adding GPCR structure models and ligands
- (2017) Gáspár Pándy-Szekeres et al. NUCLEIC ACIDS RESEARCH
- TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
- (2017) Salih Gencer et al. Science Signaling
- Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease
- (2017) Ming Ma et al. Cold Spring Harbor Perspectives in Biology
- G-Protein-Coupled Receptor Signaling in Cilia
- (2017) Kirk Mykytyn et al. Cold Spring Harbor Perspectives in Biology
- KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
- (2017) Kenneth B. Schou et al. Nature Communications
- Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements
- (2017) Katerina Toropova et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis
- (2017) Salih Gencer et al. Science Signaling
- The primary cilium is necessary for the differentiation and the maintenance of human adipose progenitors into myofibroblasts
- (2017) N. Arrighi et al. Scientific Reports
- The role of primary cilia in obesity and diabetes
- (2016) Francesco Volta et al. Annals of the New York Academy of Sciences
- Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium
- (2016) Yan-Fang Xie et al. BONE
- The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs
- (2016) Peter S. Shen et al. CELL
- The intraflagellar transport machinery in ciliary signaling
- (2016) André Mourão et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- CPAP promotes timely cilium disassembly to maintain neural progenitor pool
- (2016) Elke Gabriel et al. EMBO JOURNAL
- Phosphorylation‐dependent Akt–Inversin interaction at the basal body of primary cilia
- (2016) Futoshi Suizu et al. EMBO JOURNAL
- ATR promotes cilia signalling: links to developmental impacts
- (2016) Tom Stiff et al. HUMAN MOLECULAR GENETICS
- Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport
- (2016) Meriam Boubakri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium
- (2016) Kasturi Pal et al. JOURNAL OF CELL BIOLOGY
- Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion
- (2016) Chia-Yih Wang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Calcium contradictions in cilia
- (2016) Dominic P. Norris et al. NATURE
- Primary cilia are not calcium-responsive mechanosensors
- (2016) M. Delling et al. NATURE
- Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
- (2016) Mariana Grieben et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling
- (2016) Verena A. Bachmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development
- (2016) Kazuo Noda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endocytic Control of Cellular Signaling at the Primary Cilium
- (2016) Lotte B. Pedersen et al. TRENDS IN BIOCHEMICAL SCIENCES
- The Intraflagellar Transport Machinery
- (2016) Michael Taschner et al. Cold Spring Harbor Perspectives in Biology
- Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways
- (2016) Kunxin Luo Cold Spring Harbor Perspectives in Biology
- Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling
- (2016) Søren T. Christensen et al. Cold Spring Harbor Perspectives in Biology
- Multiciliated Cells in Animals
- (2016) Alice Meunier et al. Cold Spring Harbor Perspectives in Biology
- Signaling Receptors for TGF-β Family Members
- (2016) Carl-Henrik Heldin et al. Cold Spring Harbor Perspectives in Biology
- Regulation of TGF-β Family Signaling by Inhibitory Smads
- (2016) Keiji Miyazawa et al. Cold Spring Harbor Perspectives in Biology
- Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition
- (2016) Francesc R. Garcia-Gonzalo et al. Cold Spring Harbor Perspectives in Biology
- Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
- (2016) Xue Yuan et al. Nature Communications
- Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
- (2016) Mariana Grieben et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Role for the IFT-A Complex in Selective Transport to the Primary Cilium
- (2016) Wenxiang Fu et al. Cell Reports
- KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer
- (2016) Minsuh Kim et al. Scientific Reports
- TGFβ1 – induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner
- (2016) Marie-Noëlle Labour et al. Scientific Reports
- Cystic Kidney Disease: A Primer
- (2015) Monica T. Cramer et al. ADVANCES IN CHRONIC KIDNEY DISEASE
- Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)
- (2015) Yingzi Yang et al. Annual Review of Cell and Developmental Biology
- Proteomics of Primary Cilia by Proximity Labeling
- (2015) David U. Mick et al. DEVELOPMENTAL CELL
- Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output
- (2015) Marcelo Chávez et al. DEVELOPMENTAL CELL
- Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling
- (2015) Francesc R. Garcia-Gonzalo et al. DEVELOPMENTAL CELL
- TGR5 in the Cholangiociliopathies
- (2015) Tatyana V. Masyuk et al. DIGESTIVE DISEASES
- The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway
- (2015) Z. A. Abdelhamed et al. Disease Models & Mechanisms
- Ins and outs of GPCR signaling in primary cilia
- (2015) K. B. Schou et al. EMBO REPORTS
- Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability
- (2015) Gang Yao et al. HUMAN MOLECULAR GENETICS
- Specific variants in WDR35 cause a distinctive form of Ellis-van Creveld syndrome by disrupting the recruitment of the EvC complex and SMO into the cilium
- (2015) José A. Caparrós-Martín et al. HUMAN MOLECULAR GENETICS
- The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels
- (2015) Jaskirat Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium
- (2015) Christoph Gerhardt et al. JOURNAL OF CELL BIOLOGY
- Ciliary adenylyl cyclases control the Hedgehog pathway
- (2015) L. Vuolo et al. JOURNAL OF CELL SCIENCE
- PDGFR and oncogenic mutant PDGFR D842V promote disassembly of primary cilia through a PLC - and AURKA-dependent mechanism
- (2015) B. S. Nielsen et al. JOURNAL OF CELL SCIENCE
- TGF-β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells
- (2015) Makiri Kawasaki et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity
- (2015) Nicole L. Umberger et al. MOLECULAR BIOLOGY OF THE CELL
- Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia
- (2015) Bram Prevo et al. NATURE CELL BIOLOGY
- Lineage specificity of primary cilia in the mouse embryo
- (2015) Fiona K. Bangs et al. NATURE CELL BIOLOGY
- Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation
- (2015) Paulina Falcón-Urrutia et al. PLoS One
- β-Arrestin–biased signaling mediates memory reconsolidation
- (2015) Xing Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation
- (2015) Melis T. Dalbay et al. STEM CELLS
- IFT–Cargo Interactions and Protein Transport in Cilia
- (2015) Karl F. Lechtreck TRENDS IN BIOCHEMICAL SCIENCES
- Ciliary ectosomes: transmissions from the cell's antenna
- (2015) Christopher R. Wood et al. TRENDS IN CELL BIOLOGY
- Regulation of energy homeostasis by the NPY system
- (2015) Kim Loh et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment
- (2015) Yue Jiang et al. Nature Communications
- GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis
- (2015) Boyan Zhang et al. PLOS BIOLOGY
- Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding
- (2015) Muqing Cao et al. eLife
- Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control
- (2015) Yoshihiro Omori et al. PLoS One
- G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning
- (2014) Sun-Hee Hwang et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Molecular Pathways: Cbl Proteins in Tumorigenesis and Antitumor Immunity--Opportunities for Cancer Treatment
- (2014) M. S. Liyasova et al. CLINICAL CANCER RESEARCH
- Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila
- (2014) L. T. Vuong et al. DEVELOPMENT
- IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment
- (2014) Thibaut Eguether et al. DEVELOPMENTAL CELL
- Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly
- (2014) Michael Taschner et al. JOURNAL OF CELL BIOLOGY
- Hsp90 forms a stable complex at the cilium neck for the interaction of signalling molecules in IGF-1 receptor signalling
- (2014) H. Wang et al. JOURNAL OF CELL SCIENCE
- Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators
- (2014) Yangfan P. Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Endothelial Cilia Are Essential for Developmental Vascular Integrity in Zebrafish
- (2014) S. Kallakuri et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
- (2014) Mu He et al. NATURE CELL BIOLOGY
- Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport
- (2014) Daqing Jin et al. NATURE CELL BIOLOGY
- Primary Cilia in the Developing and Mature Brain
- (2014) Alicia Guemez-Gamboa et al. NEURON
- BBS4 Is Necessary for Ciliary Localization of TrkB Receptor and Activation by BDNF
- (2014) Carmen C. Leitch et al. PLoS One
- Hippocampal and Cortical Primary Cilia Are Required for Aversive Memory in Mice
- (2014) Nicolas F. Berbari et al. PLoS One
- Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons
- (2014) A. I. Koemeter-Cox et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis
- (2014) R. M. Das et al. SCIENCE
- G-protein-coupled receptors, Hedgehog signaling and primary cilia
- (2014) Saikat Mukhopadhyay et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents
- (2014) Jantje M. Gerdes et al. Nature Communications
- Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling
- (2014) Pawel Niewiadomski et al. Cell Reports
- Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development
- (2014) Jacky G. Goetz et al. Cell Reports
- Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception
- (2014) Shen Yue et al. eLife
- Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells
- (2014) Viralkumar S. Upadhyay et al. Frontiers in Physiology
- Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling
- (2013) Anatoliy I. Masyuk et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Wnt/β-catenin signalling: from plasma membrane to nucleus
- (2013) Wantae Kim et al. BIOCHEMICAL JOURNAL
- The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling
- (2013) Saikat Mukhopadhyay et al. CELL
- Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli
- (2013) Xingjian Jin et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The Cilium Secretes Bioactive Ectosomes
- (2013) Christopher R. Wood et al. CURRENT BIOLOGY
- IGF-1 Activates a Cilium-Localized Noncanonical Gβγ Signaling Pathway that Regulates Cell-Cycle Progression
- (2013) Celine Yeh et al. DEVELOPMENTAL CELL
- Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase
- (2013) Karl F. Lechtreck et al. JOURNAL OF CELL BIOLOGY
- Functional interaction between autophagy and ciliogenesis
- (2013) Olatz Pampliega et al. NATURE
- The roles of evolutionarily conserved functional modules in cilia-related trafficking
- (2013) Ching-Hwa Sung et al. NATURE CELL BIOLOGY
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Ciliary Protein Ftm Is Required for Ventricular Wall and Septal Development
- (2013) Christoph Gerhardt et al. PLoS One
- Inversin/Nephrocystin-2 Is Required for Fibroblast Polarity and Directional Cell Migration
- (2013) Iben R. Veland et al. PLoS One
- Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice
- (2013) N. F. Berbari et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81
- (2013) S. Bhogaraju et al. SCIENCE
- The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction
- (2013) J. Green et al. Cold Spring Harbor Perspectives in Biology
- Cilia and coordination of signaling networks during heart development
- (2013) Karen Koefoed et al. Organogenesis
- Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia
- (2013) Alexander V. Loktev et al. Cell Reports
- TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium
- (2013) Christian Alexandro Clement et al. Cell Reports
- Evidence for reciliation of RPE1 cells in late G1 phase, and ciliary localisation of cyclin B1
- (2013) Cosma Spalluto et al. FEBS Open Bio
- Kinesin motors and primary cilia
- (2012) Kristen J. Verhey et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases
- (2012) Bhopal Mohapatra et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cilia, calcium and the basis of left-right asymmetry
- (2012) Dominic P Norris BMC BIOLOGY
- The extracellular matrix and ciliary signaling
- (2012) Tamina Seeger-Nukpezah et al. CURRENT OPINION IN CELL BIOLOGY
- IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport
- (2012) Brian T. Keady et al. DEVELOPMENTAL CELL
- A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia
- (2012) Karolin V. Dorn et al. DEVELOPMENTAL CELL
- Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway
- (2012) Kyung Ho Lee et al. EMBO JOURNAL
- SARA is dispensable for functional TGF-β signaling
- (2012) Maren Bakkebø et al. FEBS LETTERS
- The Ciliary Protein Nephrocystin-4 Translocates the Canonical Wnt Regulator Jade-1 to the Nucleus to Negatively Regulate β-Catenin Signaling
- (2012) Lori Borgal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity
- (2012) Alexia Mahuzier et al. JOURNAL OF CELL BIOLOGY
- The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
- (2012) Karel F. Liem et al. JOURNAL OF CELL BIOLOGY
- PDGFR signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways
- (2012) D. L. Clement et al. JOURNAL OF CELL SCIENCE
- Context-Dependent Regulation of Wnt Signaling through the Primary Cilium
- (2012) E. C. Oh et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Oxysterols are allosteric activators of the oncoprotein Smoothened
- (2012) Sigrid Nachtergaele et al. Nature Chemical Biology
- The complex world of WNT receptor signalling
- (2012) Christof Niehrs NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Interneuron dysfunction in psychiatric disorders
- (2012) Oscar Marín NATURE REVIEWS NEUROSCIENCE
- Kinesin-2 family in vertebrate ciliogenesis
- (2012) C. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium
- (2012) M. F. Bijlsma et al. Science Signaling
- Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling
- (2012) B. T. MacDonald et al. Cold Spring Harbor Perspectives in Biology
- Association of PKD2 (Polycystin 2) Mutations With Left-Right Laterality Defects
- (2011) Stanislas Bataille et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition
- (2011) Anastasia D. Egorova et al. CIRCULATION RESEARCH
- Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
- (2011) M. Tuson et al. DEVELOPMENT
- Stages of ciliogenesis and regulation of ciliary length
- (2011) Prachee Avasthi et al. DIFFERENTIATION
- Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros
- (2011) Céline Burcklé et al. HUMAN MOLECULAR GENETICS
- Dopamine Receptor Type 5 in the Primary Cilia Has Dual Chemo- and Mechano-Sensory Roles
- (2011) Shakila Abdul-Majeed et al. HYPERTENSION
- Subunit Interactions and Organization of theChlamydomonas reinhardtiiIntraflagellar Transport Complex A Proteins
- (2011) Robert H. Behal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Type 3 Adenylyl Cyclase Is Required for Novel Object Learning and Extinction of Contextual Memory: Role of cAMP Signaling in Primary Cilia
- (2011) Z. Wang et al. JOURNAL OF NEUROSCIENCE
- Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling
- (2011) Søren T Christensen et al. JOURNAL OF PATHOLOGY
- Subcellular spatial regulation of canonical Wnt signalling at the primary cilium
- (2011) Madeline A. Lancaster et al. NATURE CELL BIOLOGY
- Complex interactions between genes controlling trafficking in primary cilia
- (2011) Polloneal Jymmiel R Ocbina et al. NATURE GENETICS
- Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome
- (2011) Madeline A Lancaster et al. NATURE MEDICINE
- Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium
- (2011) A. L. Blitzer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases
- (2011) Y.-H. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components
- (2011) J. Qin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome
- (2011) C. J. Westlake et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
- (2011) Yongbin Chen et al. PLOS BIOLOGY
- The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
- (2010) Verena Keitel et al. BIOLOGICAL CHEMISTRY
- The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia
- (2010) Hua Jin et al. CELL
- Cell Signaling by Receptor Tyrosine Kinases
- (2010) Mark A. Lemmon et al. CELL
- Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins
- (2010) Jacqueline S. Domire et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts
- (2010) Linda Schneider et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development
- (2010) Kimberly M. McDermott et al. CURRENT BIOLOGY
- Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets
- (2010) Maarten F Bijlsma et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2
- (2010) Florian Witte et al. FASEB JOURNAL
- The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
- (2010) E. W. Humke et al. GENES & DEVELOPMENT
- TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
- (2010) S. Mukhopadhyay et al. GENES & DEVELOPMENT
- Somatostatin Signaling in Neuronal Cilia Is Criticalfor Object Recognition Memory
- (2010) E. B. Einstein et al. JOURNAL OF NEUROSCIENCE
- Ror2/Frizzled Complex Mediates Wnt5a-Induced AP-1 Activation by Regulating Dishevelled Polymerization
- (2010) M. Nishita et al. MOLECULAR AND CELLULAR BIOLOGY
- The primary cilium: a signalling centre during vertebrate development
- (2010) Sarah C. Goetz et al. NATURE REVIEWS GENETICS
- Inversin relays Frizzled-8 signals to promote proximal pronephros development
- (2010) S. Lienkamp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
- (2009) P. Huang et al. DEVELOPMENT
- Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
- (2009) Jinping Jia et al. DEVELOPMENTAL BIOLOGY
- Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling
- (2009) Ryan X. Norman et al. HUMAN MOLECULAR GENETICS
- Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
- (2009) Victoria L. Patterson et al. HUMAN MOLECULAR GENETICS
- The Na+/H+exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium
- (2009) Linda Schneider et al. JOURNAL OF CELL BIOLOGY
- TheChlamydomonas reinhardtiiBBSome is an IFT cargo required for export of specific signaling proteins from flagella
- (2009) Karl-Ferdinand Lechtreck et al. JOURNAL OF CELL BIOLOGY
- Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes
- (2009) D. Zhu et al. JOURNAL OF CELL SCIENCE
- INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
- (2009) Monique Jacoby et al. NATURE GENETICS
- Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
- (2009) Stephanie L Bielas et al. NATURE GENETICS
- Impaired Wnt–β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy
- (2009) Madeline A Lancaster et al. NATURE MEDICINE
- Primary Cilia Are Not Required for Normal Canonical Wnt Signaling in the Mouse Embryo
- (2009) Polloneal Jymmiel R. Ocbina et al. PLoS One
- Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
- (2009) K. F. Liem et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation
- (2009) Vincent Marion et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of Nephrocystin-3 Function Can Cause Embryonic Lethality, Meckel-Gruber-like Syndrome, Situs Inversus, and Renal-Hepatic-Pancreatic Dysplasia
- (2008) Carsten Bergmann et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors
- (2008) Anatoliy I. Masyuk et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Primary cilia sensitize endothelial cells for fluid shear stress
- (2008) Beerend P. Hierck et al. DEVELOPMENTAL DYNAMICS
- Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone
- (2008) Alexandre I. Danilov et al. GLIA
- Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors
- (2008) Nicolas F. Berbari et al. MOLECULAR BIOLOGY OF THE CELL
- Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL
- (2008) Vipul C. Chitalia et al. NATURE CELL BIOLOGY
- Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
- (2008) N. F. Berbari et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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