The nphp-2 and arl-13 Genetic Modules Interact to Regulate Ciliogenesis and Ciliary Microtubule Patterning in C. elegans

The primary cilium

(2014) Andrew M Fry et al.   Organogenesis

Compartments within a compartment

(2014) Oliver E Blacque et al.   Organogenesis

A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans

(2014) David B Doroquez et al.   eLife

Expanding Horizons: Ciliary Proteins Reach Beyond Cilia

(2013) Shiaulou Yuan et al.   Annual Review of Genetics

Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli

(2013) Xingjian Jin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Compartmentalized Calcium Signaling in Cilia Regulates Intraflagellar Transport

(2013) Peter Collingridge et al.   CURRENT BIOLOGY

Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the ciliary tip during ciliary assembly

(2013) T. V. Satish Tammana et al.   JOURNAL OF CELL SCIENCE

Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans

(2013) M. Wojtyniak et al.   JOURNAL OF CELL SCIENCE

Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control

(2013) Peter K. Jackson   MOLECULAR CELL

ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3

(2013) Sylvia Hoff et al.   NATURE GENETICS

The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly

(2013) M. Mergen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Roles of cilia, fluid flow, and Ca2+ signaling in breaking of left–right symmetry

(2013) Satoko Yoshiba et al.   TRENDS IN GENETICS

Wnt and planar cell polarity signaling in cystic renal disease

(2013) Paraskevi Goggolidou   Organogenesis

Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain

(2013) Sebiha Cevik et al.   PLoS Genetics

Targeting of Nphp3 to the primary cilia is controlled by an N-terminal myristoylation site and coiled-coil domains

(2012) Kana Nakata et al.   Cytoskeleton

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors

(2012) Yujie Li et al.   JOURNAL OF CELL BIOLOGY

Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins

(2012) S. R. F. Warburton-Pitt et al.   JOURNAL OF CELL SCIENCE

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium

(2012) Ji Eun Lee et al.   NATURE GENETICS

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

The Tubulin Deglutamylase CCPP-1 Regulates the Function and Stability of Sensory Cilia in C. elegans

(2011) Robert O'Hagan et al.   CURRENT BIOLOGY

Kinesin-3 KLP-6 Regulates Intraflagellar Transport in Male-Specific Cilia of Caenorhabditis elegans

(2011) Natalia S. Morsci et al.   CURRENT BIOLOGY

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

(2011) K. J. Wright et al.   GENES & DEVELOPMENT

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

(2011) Corey L. Williams et al.   JOURNAL OF CELL BIOLOGY

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

(2011) Christine E. Larkins et al.   MOLECULAR BIOLOGY OF THE CELL

UNC119 is required for G protein trafficking in sensory neurons

(2011) Houbin Zhang et al.   NATURE NEUROSCIENCE

Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity

(2010) Swati Suryavanshi et al.   CURRENT BIOLOGY

Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins

(2010) Tomohiro Kubo et al.   CURRENT BIOLOGY

Functional Specialization of Sensory Cilia by an RFX Transcription Factor Isoform

(2010) J. Wang et al.   GENETICS

Identification of Tubulin Deglutamylase amongCaenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)

(2010) Yoshishige Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

(2010) Yujie Li et al.   JOURNAL OF CELL BIOLOGY

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport inCaenorhabditis elegans

(2010) Sebiha Cevik et al.   JOURNAL OF CELL BIOLOGY

The primary cilium at a glance

(2010) P. Satir et al.   JOURNAL OF CELL SCIENCE

Normal Ciliogenesis Requires Synergy between the Cystic Kidney Disease Genes MKS-3 and NPHP-4

(2010) C. L. Williams et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

(2010) Chih-Wen Chu et al.   MOLECULAR BIOLOGY OF THE CELL

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

Spatial Distribution of Calcium-Gated Chloride Channels in Olfactory Cilia

(2010) Donald A. French et al.   PLoS One

The CIL-1 PI 5-Phosphatase Localizes TRP Polycystins to Cilia and Activates Sperm in C. elegans

(2009) Young-Kyung Bae et al.   CURRENT BIOLOGY

Characterization of mouse IFT complex B

(2009) John A. Follit et al.   CELL MOTILITY AND THE CYTOSKELETON

Loss of Nephrocystin-3 Function Can Cause Embryonic Lethality, Meckel-Gruber-like Syndrome, Situs Inversus, and Renal-Hepatic-Pancreatic Dysplasia

(2008) Carsten Bergmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in the Cilia Gene ARL13B Lead to the Classical Form of Joubert Syndrome

(2008) Vincent Cantagrel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation

(2008) Yuji Hori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TheCaenorhabditis elegansnephrocystins act as global modifiers of cilium structure

(2008) Andrew R. Jauregui et al.   JOURNAL OF CELL BIOLOGY

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region

(2008) D. Shiba et al.   JOURNAL OF CELL SCIENCE

NEK8 Mutations Affect Ciliary and Centrosomal Localization and May Cause Nephronophthisis

(2008) E. A. Otto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY