标题
The cell biology of APOE in the brain
作者
关键词
-
出版物
TRENDS IN CELL BIOLOGY
Volume -, Issue -, Pages -
出版商
Elsevier BV
发表日期
2023-10-05
DOI
10.1016/j.tcb.2023.09.004
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Association between Apolipoprotein E genotype and functional outcome in acute ischemic stroke
- (2023) Xiaoming Rong et al. Aging-US
- APOE expression and secretion are modulated by mitochondrial dysfunction
- (2023) Meghan E Wynne et al. eLife
- APOE ε4 associates with microglial activation independently of Aβ plaques and tau tangles
- (2023) João Pedro Ferrari-Souza et al. Science Advances
- Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration
- (2023) Yashi Mi et al. Nature Metabolism
- Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins
- (2022) Gianna M. Fote et al. JOURNAL OF CELL SCIENCE
- APOE4 confers transcriptomic and functional alterations to primary mouse microglia
- (2022) Saima I. Machlovi et al. NEUROBIOLOGY OF DISEASE
- Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
- (2022) Laura K. Hamilton et al. Nature Communications
- Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
- (2022) Julia TCW et al. CELL
- Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity
- (2022) Matheus B. Victor et al. Cell Stem Cell
- Common human genetic variants of APOE impact murine COVID-19 mortality
- (2022) Benjamin N. Ostendorf et al. NATURE
- Aged lipid‐laden microglia display impaired responses to stroke
- (2022) Maria Arbaizar‐Rovirosa et al. EMBO Molecular Medicine
- APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
- (2022) Joel W. Blanchard et al. NATURE
- ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
- (2021) Guoyuan Qi et al. Cell Reports
- APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
- (2021) Grzegorz Sienski et al. Science Translational Medicine
- Neurotoxic reactive astrocytes induce cell death via saturated lipids
- (2021) Kevin A. Guttenplan et al. NATURE
- NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load
- (2021) Theresa Pohlkamp et al. eLife
- APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes
- (2021) Sherida M. de Leeuw et al. Stem Cell Reports
- Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
- (2020) Julia Marschallinger et al. NATURE NEUROSCIENCE
- APOE alters glucose flux through central carbon pathways in astrocytes
- (2020) Holden C. Williams et al. NEUROBIOLOGY OF DISEASE
- APOE genotype regulates pathology and disease progression in synucleinopathy
- (2020) Albert A. Davis et al. Science Translational Medicine
- Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
- (2020) Eric M. Reiman et al. Nature Communications
- Common germline variants of the human APOE gene modulate melanoma progression and survival
- (2020) Benjamin N. Ostendorf et al. NATURE MEDICINE
- Altered mitochondrial dynamics and function in APOE4-expressing astrocytes
- (2020) Eran Schmukler et al. Cell Death & Disease
- PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4
- (2020) Priyanka Narayan et al. Cell Reports
- Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
- (2020) Yun Chen et al. NEURON
- Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation
- (2019) Brandon Farmer et al. Cells
- Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
- (2019) Maria S. Ioannou et al. CELL
- Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report
- (2019) Joseph F. Arboleda-Velasquez et al. NATURE MEDICINE
- A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes
- (2018) Kirill Bersuker et al. DEVELOPMENTAL CELL
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
- (2018) Yuan-Ta Lin et al. NEURON
- Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH
- (2018) Hari Prasad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach
- (2018) Nicolas Henry et al. PLoS Computational Biology
- APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology
- (2018) Dennis W. Dickson et al. NEUROLOGY
- Dynamics and functions of lipid droplets
- (2018) James A. Olzmann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease
- (2018) Xunde Xian et al. eLife
- Astrocyte lipid metabolism is critical for synapse development and function in vivo
- (2017) Anne-Lieke F. van Deijk et al. GLIA
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease
- (2017) Courtney Lane-Donovan et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
- (2017) Tal Nuriel et al. Frontiers in Neuroscience
- Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes
- (2016) Marilia Kimie Shimabukuro et al. Scientific Reports
- Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
- (2015) Lucy Liu et al. CELL
- Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease
- (2015) Laura K. Hamilton et al. Cell Stem Cell
- Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells
- (2015) Mitsuhiro Nakato et al. JOURNAL OF LIPID RESEARCH
- Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis
- (2015) Li Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
- (2013) Jason D Ulrich et al. Molecular Neurodegeneration
- Intracellular Trafficking and Secretion of VLDL
- (2012) Samata Tiwari et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia
- (2011) Jianjia Fan et al. JOURNAL OF LIPID RESEARCH
- Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease
- (2011) Giuseppe Astarita et al. PLoS One
- Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
- (2011) J. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cholesterol metabolism in neurons and astrocytes
- (2011) Frank W. Pfrieger et al. PROGRESS IN LIPID RESEARCH
- Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease
- (2010) Lesley Jones et al. PLoS One
- ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
- (2010) Y. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Apolipoprotein E: From lipid transport to neurobiology
- (2010) Paul S. Hauser et al. PROGRESS IN LIPID RESEARCH
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
- (2009) Denise Harold et al. NATURE GENETICS
- APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway
- (2008) Sigrid B Sando et al. BMC Neurology
- LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins
- (2008) Veronica Hirsch-Reinshagen et al. JOURNAL OF LIPID RESEARCH
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