Aged lipid‐laden microglia display impaired responses to stroke

Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells

(2022) Beatriz Lozano-Ruiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

(2022) Carolin Beuker et al.   Nature Communications

Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells

(2021) Sissel Ida Schmidt et al.   Stem Cell Reports

White matter aging drives microglial diversity

(2021) Shima Safaiyan et al.   NEURON

Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response

(2021) E. A. Monson et al.   Nature Communications

Context‐dependent transcriptional regulation of microglial proliferation

(2021) Sarah Belhocine et al.   GLIA

Repeated Administration of 2-Hydroxypropyl-β-Cyclodextrin (HPβCD) Attenuates the Chronic Inflammatory Response to Experimental Stroke

(2021) Danielle A. Becktel et al.   JOURNAL OF NEUROSCIENCE

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

(2020) Emily F. Willis et al.   CELL

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Investigating Microglia in Health and Disease: Challenges and Opportunities

(2020) Veronique E. Miron et al.   TRENDS IN IMMUNOLOGY

Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain

(2020) Peter Androvic et al.   Cell Reports

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

(2020) Jeremy Carlos Burns et al.   eLife

Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function

(2020) Nguyen T.T. Truong et al.   CYTOKINE

CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages

(2020) Fengyang Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs

(2020) Mattia Gallizioli et al.   Cell Reports

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

(2020) Csaba Cserép et al.   NEURON

Microglia depletion increase brain injury after acute ischemic stroke in aged mice

(2020) Shirley Marino Lee et al.   EXPERIMENTAL NEUROLOGY

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

(2019) Emily G. O’Koren et al.   IMMUNITY

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

Aging alters the immunological response to ischemic stroke

(2018) Rodney M. Ritzel et al.   ACTA NEUROPATHOLOGICA

Impact of estrogens and estrogen receptor-α in brain lipid metabolism

(2018) Eugenia Morselli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

Lipid droplet density alters the early innate immune response to viral infection

(2018) Ebony A. Monson et al.   PLoS One

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

(2018) Matthew Knight et al.   PLoS Pathogens

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders

(2018) Jinming Han et al.   GLIA

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

(2018) Shane M. O’Neil et al.   Acta Neuropathologica Communications

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke

(2015) Vasileios-Arsenios Lioutas et al.   Translational Stroke Research

Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads

(2014) Hongshan Jiang et al.   BMC BIOINFORMATICS

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Microglial pathology

(2014) Wolfgang J Streit et al.   Acta Neuropathologica Communications

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Targeting Mannose-Binding Lectin Confers Long-Lasting Protection With a Surprisingly Wide Therapeutic Window in Cerebral Ischemia

(2012) Franca Orsini et al.   CIRCULATION

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

The Effects of Estrogen in Ischemic Stroke

(2012) Edward C. Koellhoffer et al.   Translational Stroke Research

Peroxisomal alterations in Alzheimer’s disease

(2011) Jianqiu Kou et al.   ACTA NEUROPATHOLOGICA

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

(2011) Tatsuya Saitoh et al.   IMMUNITY

Ischemic stroke in the elderly: an overview of evidence

(2010) Ruo-Li Chen et al.   Nature Reviews Neurology

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Influence of Age on Outcome From Thrombolysis in Acute Stroke

(2010) Nishant Kumar Mishra et al.   STROKE