APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

(2021) Guoyuan Qi et al.   Cell Reports

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

(2021) Grzegorz Sienski et al.   Science Translational Medicine

The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes

(2020) Lin Cui et al.   Frontiers in Cell and Developmental Biology

APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease

(2020) Hussein N. Yassine et al.   Frontiers in Aging Neuroscience

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions

(2020) Zhen Liang et al.   Frontiers in Neurology

Corrigendum to “Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line” [Stem Cell Res. 34/1873–5061 (2019) 101349–55]

(2020) Benjamin Schmid et al.   Stem Cell Research

PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

(2020) Priyanka Narayan et al.   Cell Reports

Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line

(2019) Benjamin Schmid et al.   Stem Cell Research

The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

(2019) Celia G. Fernandez et al.   Frontiers in Aging Neuroscience

Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling

(2019) Sherida de Leeuw et al.   Translational Neurodegeneration

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

(2019) Varun Rawat et al.   JOURNAL OF NEUROSCIENCE

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

(2018) Daniel J. Colacurcio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway

(2018) Jianjia Fan et al.   JOURNAL OF LIPID RESEARCH

Cell-specific production, secretion, and function of apolipoprotein E

(2018) Maaike Kockx et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

(2018) Long Wu et al.   JOURNAL OF NEUROSCIENCE

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

(2017) Tal Nuriel et al.   Frontiers in Neuroscience

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

(2017) Julia TCW et al.   Stem Cell Reports

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Activation of liver X receptor attenuates lysophosphatidylcholine-induced IL-8 expression in endothelial cellsviathe NF-κB pathway and SUMOylation

(2016) Xukun Bi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

(2016) Ignacio Sancho-Martinez et al.   Nature Communications

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

(2014) Daniel M. Michaelson   Alzheimers & Dementia

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors

(2012) Jihong Kang et al.   ENDOCRINE REVIEWS

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

(2012) Jacob M. Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals

(2012) Sonya B. Dumanis et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

(2010) Heather A. Scott et al.   NEUROBIOLOGY OF AGING

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway

(2009) R Do et al.   CLINICAL GENETICS

Thin, Stubby or Mushroom: Spine Pathology in Alzheimers Disease

(2009) C. Tackenberg et al.   Current Alzheimer Research