Synthesis, antibacterial activity evaluation and molecular docking studies of coumarin modified thiouracil derivatives as SecA inhibitor

Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents

(2022) Xun-Cai Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel Hybrids of 3-Substituted Coumarin and Phenylsulfonylfuroxan as Potent Antitumor Agents with Collateral Sensitivity against MCF-7/ADR

(2022) Zhihui Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors

(2021) Fante Bamba et al.   MEDICINAL CHEMISTRY RESEARCH

Coumarin Sulfonamides and Amides Derivatives: Design, Synthesis, and Antitumor Activity In Vitro

(2021) Jing Zhang et al.   MOLECULES

Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria

(2021) Pei Zhou et al.   ACCOUNTS OF CHEMICAL RESEARCH

Discovery of Novel SecA Inhibitors against ‘ Candidatus Liberibacter asiaticus’ through Virtual Screening and Biological Evaluation

(2021) Zhengfang Zhang et al.   Chemical Biology & Drug Design

Introduction: Drug Resistance

(2021) Nese Kurt Yilmaz et al.   CHEMICAL REVIEWS

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

(2021) Sonia Huecas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antibacterial activities and molecular docking study of thiouracil derivatives containing oxadiazole moiety

(2021) Peng-Lei Cui et al.   SYNTHETIC COMMUNICATIONS

Bacterial Resistance to Antimicrobial Agents

(2021) Manuel F. Varela et al.   Antibiotics-Basel

Computational Design and Development of Benzodioxane-Benzamides as Potent Inhibitors of FtsZ by Exploring the Hydrophobic Subpocket

(2021) Valentina Straniero et al.   Antibiotics-Basel

Design, multistep synthesis and in-vitro antimicrobial and antioxidant screening of coumarin clubbed chalcone hybrids through molecular hybridization approach

(2021) Sathish Kumar Konidala et al.   Arabian Journal of Chemistry

Inhibition of LpxC Increases the Activity of Iron Chelators and Gallium Nitrate in Multidrug-Resistant Acinetobacter baumannii

(2021) Víctor Vinuesa et al.   Antibiotics-Basel

The antibacterial activity of fluoroquinolone derivatives: An update (2018–2021)

(2021) Yanshu Jia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel peptidomimetic peptide deformylase (PDF) inhibitors of Mycobacterium tuberculosis

(2020) Kunal M. Gokhale et al.   Chemical Biology & Drug Design

Synthesis and biological evaluation of novel 4-oxo-5-cyano thiouracil derivatives as SecA inhibitors

(2020) Fante Bamba et al.   HETEROCYCLIC COMMUNICATIONS

Antibacterial activities with the structure-activity relationship of coumarin derivatives

(2020) Hua-Li Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Coumarin derivatives as promising antibacterial agent(s)

(2020) Chita Ranjan Sahoo et al.   Arabian Journal of Chemistry

Discovery of Potential Plant-Derived Peptide Deformylase (PDF) Inhibitors for Multidrug-Resistant Bacteria Using Computational Studies

(2018) Shailima Rampogu et al.   Journal of Clinical Medicine

Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity

(2017) Alessandra Bisi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors

(2017) Penglei Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

(2017) Seth W. Dickey et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic potential of coumarins as antiviral agents

(2016) Mohd. Zaheen Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of a Microemulsion Formulation for Antimicrobial SecA Inhibitors

(2016) Jiahuai Hu et al.   PLoS One

Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus

(2015) Jinshan Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors

(2015) Jianmei Cui et al.   ChemMedChem

Design, Synthesis and Biological Evaluation of Rose Bengal Analogues as SecA Inhibitors

(2013) Jianmei Cui et al.   ChemMedChem

The first low μM SecA inhibitors

(2010) Weixuan Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry