Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

Detection ofmcr-1among Escherichia coli Clinical Isolates Collected Worldwide as Part of the SENTRY Antimicrobial Surveillance Program in 2014 and 2015

(2016) Mariana Castanheira et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii

(2016) Meritxell García-Quintanilla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Obiltoxaximab Prevents Disseminated Bacillus anthracis Infection and Improves Survival during Pre- and Postexposure Prophylaxis in Animal Models of Inhalational Anthrax

(2016) Brent J. Yamamoto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Escherichia coli Harboringmcr-1andblaCTX-Mon a Novel IncF Plasmid: First Report ofmcr-1in the United States

(2016) Patrick McGann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis

(2016) Tomas N. Gustafsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

(2016) Cassie Jarvis et al.   ChemMedChem

Obiltoxaximab: First Global Approval

(2016) Sarah L. Greig   DRUGS

Target-Agnostic Identification of Functional Monoclonal Antibodies AgainstKlebsiella pneumoniaeMultimeric MrkA Fimbrial Subunit

(2016) Qun Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 ImpairsPseudomonas aeruginosaPathogenicity and Inflammasome Activation

(2016) Ahalieyah Anantharajah et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections

(2016) Stefanie Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies

(2016) Adriana Badarau et al.   mAbs

Interconnected microbiomes and resistomes in low-income human habitats

(2016) Erica C. Pehrsson et al.   NATURE

Clostridium difficile colitis: pathogenesis and host defence

(2016) Michael C. Abt et al.   NATURE REVIEWS MICROBIOLOGY

ESX secretion systems: mycobacterial evolution to counter host immunity

(2016) Matthias I. Gröschel et al.   NATURE REVIEWS MICROBIOLOGY

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

Cospeciation of gut microbiota with hominids

(2016) A. H. Moeller et al.   SCIENCE

Accessory Gene Regulator-1 Locus Is Essential for Virulence and Pathogenesis of Clostridium difficile

(2016) Charles Darkoh et al.   mBio

Colistin- and Carbapenem-Resistant Escherichia coli Harboring mcr-1 and bla NDM-5 , Causing a Complicated Urinary Tract Infection in a Patient from the United States: TABLE 1 

(2016) José R. Mediavilla et al.   mBio

Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections

(2016) Ana L. Flores-Mireles et al.   mBio

Virulence determinants associated with the Asian community-associated methicillin-resistant Staphylococcus aureus lineage ST59

(2016) Min Li et al.   Scientific Reports

Phage-mediated Shiga toxin (Stx) horizontal gene transfer and expression in non-Shiga toxigenicEnterobacterandEscherichia colistrains

(2016) Rowaida K.S. Khalil et al.   Pathogens and Disease

New Monoclonal Antibodies against a Novel Subtype of Shiga Toxin 1 Produced by Enterobacter cloacae and Their Use in Analysis of Human Serum

(2016) Craig Skinner et al.   mSphere

Interactions Between the Gastrointestinal Microbiome and Clostridium difficile

(2015) Casey M. Theriot et al.   Annual Review of Microbiology

Synthesis and structure–activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)

(2015) John D. Williams et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: mechanisms of resistance, molecular identification and epidemiological data

(2015) O. Oikonomou et al.   BMC INFECTIOUS DISEASES

Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control inPseudomonas aeruginosa

(2015) Nora R. Eibergen et al.   CHEMBIOCHEM

Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance

(2015) Zubair A. Qureshi et al.   CLINICAL INFECTIOUS DISEASES

Antibacterial monoclonal antibodies: the next generation?

(2015) Antonio DiGiandomenico et al.   CURRENT OPINION IN MICROBIOLOGY

Can resistance against quorum-sensing interference be selected?

(2015) Rodolfo García-Contreras et al.   ISME Journal

Pathogenic Acinetobacter: from the Cell Surface to Infinity and Beyond

(2015) Brent S. Weber et al.   JOURNAL OF BACTERIOLOGY

A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin

(2015) Susan E. Maslanka et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular identification of tigecycline- and colistin-resistant carbapenemase-producing Acinetobacter baumannii from a Greek hospital from 2011 to 2013

(2015) Angeliki Mavroidi et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Role of LuxIR Homologue AnoIR in Acinetobacter nosocomialis and the Effect of Virstatin on the Expression of anoR Gene

(2015) Man Hwan Oh et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

(2015) Ana L. Flores-Mireles et al.   NATURE REVIEWS MICROBIOLOGY

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

(2015) Jim Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Burden of Clostridium difficile Infection in the United States

(2015) Fernanda C. Lessa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clostridium difficile Infection

(2015) Daniel A. Leffler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pheromone killing of multidrug-resistantEnterococcus faecalisV583 by native commensal strains

(2015) Michael S. Gilmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule antivirulence agent for treating Clostridium difficile infection

(2015) Kristina Oresic Bender et al.   Science Translational Medicine

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

(2015) Jim Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli

(2015) Dagmara I. Kisiela et al.   PLoS Pathogens

Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection

(2015) Sargurunathan Subashchandrabose et al.   mSphere

Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections

(2015) Shankar Thangamani et al.   Scientific Reports

Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria

(2014) Joseph P. Gerdt et al.   ACS Chemical Biology

Effects of Antibiotics on Human Microbiota and Subsequent Disease

(2014) Kristie M. Keeney et al.   Annual Review of Microbiology

Mutations in the Pseudomonas aeruginosa Needle Protein GenepscFConfer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System

(2014) Nicholas O. Bowlin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Anti-PcrV Antibody Providing Enhanced Protection against Pseudomonas aeruginosa in Multiple Animal Infection Models

(2014) Paul Warrener et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Virstatin inhibits biofilm formation and motility of Acinetobacter baumannii

(2014) Yassine Nait Chabane et al.   BMC MICROBIOLOGY

Vancomycin, Metronidazole, or Tolevamer for Clostridium difficile Infection: Results From Two Multinational, Randomized, Controlled Trials

(2014) Stuart Johnson et al.   CLINICAL INFECTIOUS DISEASES

Designing inhibitors of anthrax toxin

(2014) Ekaterina M Nestorovich et al.   Expert Opinion on Drug Discovery

Mechanisms of Neutralization of a Human Anti-α-toxin Antibody

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and Identification of an Enterobacter cloacae Strain Producing a Novel Subtype of Shiga Toxin Type 1

(2014) W. S. Probert et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Characterization of Alpha-ToxinhlaGene Variants, Alpha-Toxin Expression Levels, and Levels of Antibody to Alpha-Toxin in Hemodialysis and Postsurgical Patients with Staphylococcus aureus Bacteremia

(2014) Batu K. Sharma-Kuinkel et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins ofStaphylococcus aureuswith a single human monoclonal antibody

(2014) Harald Rouha et al.   mAbs

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Antiinfective therapy with a small molecule inhibitor ofStaphylococcus aureussortase

(2014) Jie Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

(2014) A. DiGiandomenico et al.   Science Translational Medicine

Genome-Wide Identification of Acinetobacter baumannii Genes Necessary for Persistence in the Lung

(2014) N. Wang et al.   mBio

Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic Escherichia coli

(2014) Sarah E. Greene et al.   mBio

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

(2014) Erin K. Sully et al.   PLoS Pathogens

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review

(2014) Stefan H E Kaufmann et al.   Lancet Respiratory Medicine

Development of a Peptide Antagonist against fsr Quorum Sensing of Enterococcus faecalis

(2013) Jiro Nakayama et al.   ACS Chemical Biology

Quo vadis quorum quenching?

(2013) Jie Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

The agr Locus Regulates Virulence and Colonization Genes in Clostridium difficile 027

(2013) M. J. Martin et al.   JOURNAL OF BACTERIOLOGY

Molecular Characterization of a Novel Botulinum Neurotoxin Type H Gene

(2013) Nir Dover et al.   JOURNAL OF INFECTIOUS DISEASES

A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131

(2013) Makrina Totsika et al.   JOURNAL OF INFECTIOUS DISEASES

A cell-cell communication signal integrates quorum sensing and stress response

(2013) Jasmine Lee et al.   Nature Chemical Biology

Complete Genome Sequence of a Pantón-Valentine Leukocidin-Negative Community-Associated Methicillin-Resistant Staphylococcus aureus Strain of Sequence type 72 from Korea

(2013) Yan Chen et al.   PLoS One

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The true cost of antimicrobial resistance

(2013) R. Smith et al.   BMJ-British Medical Journal

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Structure, Function, and Biology of the Enterococcus faecalis Cytolysin

(2013) Daria Van Tyne et al.   Toxins

Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil inPseudomonas aeruginosaclinical isolates

(2013) Rodolfo García-Contreras et al.   Pathogens and Disease

Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-native N-Acyl Homoserine Lactones

(2012) Danielle M. Stacy et al.   ACS Chemical Biology

In VitroandIn VivoBiological Activities of Iron Chelators and Gallium Nitrate against Acinetobacter baumannii

(2012) Louis de Léséleuc et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Activities of Iron Chelators against Common Nosocomial Pathogens

(2012) Mitchell G. Thompson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Risk Factors for the Hemolytic Uremic Syndrome in Children Infected With Escherichia coli O157:H7: A Multivariable Analysis

(2012) C. S. Wong et al.   CLINICAL INFECTIOUS DISEASES

Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010

(2012) Dawn M. Sievert et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Nosocomial outbreak of carbapenem-resistant Enterobacter cloacae highlighting the interspecies transferability of the blaOXA-48 gene in the gut flora

(2012) L. Cremet et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening

(2012) Antonio DiGiandomenico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of curli fimbriae in the biofilm formation of Enterobacter cloacae

(2012) Sung-Min Kim et al.   JOURNAL OF MICROBIOLOGY

MRSA epidemic linked to a quickly spreading colonization and virulence determinant

(2012) Min Li et al.   NATURE MEDICINE

Detection of AI-2 Receptors in Genomes of Enterobacteriaceae Suggests a Role of Type-2 Quorum Sensing in Closed Ecosystems

(2012) Fabio Rezzonico et al.   SENSORS

Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis

(2012) L. Lin et al.   mBio

Staphylococcus aureus Hemolysins, bi-component Leukocidins, and Cytolytic Peptides: A Redundant Arsenal of Membrane-Damaging Virulence Factors?

(2012) François Vandenesch et al.   Frontiers in Cellular and Infection Microbiology

Quorum quenching quandary: resistance to antivirulence compounds

(2011) Toshinari Maeda et al.   ISME Journal

A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis

(2011) S. Balu et al.   JOURNAL OF IMMUNOLOGY

Antibiotic resistance is ancient

(2011) Vanessa M. D’Costa et al.   NATURE

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

(2011) C. K. Cusumano et al.   Science Translational Medicine

The role of toxin A and toxin B in the virulence of Clostridium difficile

(2011) Glen P. Carter et al.   TRENDS IN MICROBIOLOGY

The Sociomicrobiology of Antivirulence Drug Resistance: a Proof of Concept

(2011) B. Mellbye et al.   mBio

Monoclonal Antibody Therapies against Anthrax

(2011) Zhaochun Chen et al.   Toxins

Basis of Virulence in Community-Associated Methicillin-ResistantStaphylococcus aureus

(2010) Michael Otto   Annual Review of Microbiology

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quorum sensing inAcinetobacter: an emerging pathogen

(2010) Nidhi Bhargava et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Bacteremia complicating gram-negative urinary tract infections: A population-based study

(2010) Majdi N. Al-Hasan et al.   JOURNAL OF INFECTION

Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity

(2010) Erik Chorell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

(2010) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quorum Sensing Inhibition Selects for Virulence and Cooperation in Pseudomonas aeruginosa

(2010) Thilo Köhler et al.   PLoS Pathogens

Safety and Pharmacokinetics of Urtoxazumab, a Humanized Monoclonal Antibody, against Shiga-Like Toxin 2 in Healthy Adults and in Pediatric Patients Infected with Shiga-Like Toxin-Producing Escherichia coli

(2009) E. L. Lopez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety and Pharmacokinetics of Chimeric Anti-Shiga Toxin 1 and Anti-Shiga Toxin 2 Monoclonal Antibodies in Healthy Volunteers

(2009) M. Bitzan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cytotoxic activity ofEnterobacter cloacaehuman isolates

(2009) Sylwia Krzymińska et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The changing epidemiology of resistance

(2009) P. M. Hawkey et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Covalent Inhibition of Bacterial Quorum Sensing

(2009) Neri Amara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria

(2009) Eric C Carnes et al.   Nature Chemical Biology

Raxibacumab for the Treatment of Inhalational Anthrax

(2009) Thi-Sau Migone et al.   NEW ENGLAND JOURNAL OF MEDICINE

A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa

(2009) Toshihiro Kai et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Performance of Purified Antigens for Serodiagnosis of Pulmonary Tuberculosis: a Meta-Analysis

(2008) K. R. Steingart et al.   Clinical and Vaccine Immunology

Vancomycin-Resistant Staphylococcus aureus in the United States, 2002-2006

(2008) D. M. Sievert et al.   CLINICAL INFECTIOUS DISEASES

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

An Engineered Human Antibody Fab Fragment Specific for Pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activity

(2008) M. Baer et al.   INFECTION AND IMMUNITY

Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody

(2008) K. A. D. Sauter et al.   INFECTION AND IMMUNITY

Isolation and Characterization of an Autoinducer Synthase from Acinetobacter baumannii

(2008) C. Niu et al.   JOURNAL OF BACTERIOLOGY

Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1

(2008) T. Akerlund et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Virulence evolution and the trade-off hypothesis: history, current state of affairs and the future

(2008) S. ALIZON et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES