Vagal sensory pathway for the gut-brain communication

An airway-to-brain sensory pathway mediates influenza-induced sickness

(2023) Na-Ryum Bin et al.   NATURE

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility

(2023) Elijah D. Lowenstein et al.   NEURON

Sensory representation and detection mechanisms of gut osmolality change

(2022) Takako Ichiki et al.   NATURE

The preference for sugar over sweetener depends on a gut sensor cell

(2022) Kelly L. Buchanan et al.   NATURE NEUROSCIENCE

Neural signalling of gut mechanosensation in ingestive and digestive processes

(2022) Minyoo Kim et al.   NATURE REVIEWS NEUROSCIENCE

Internal senses of the vagus nerve

(2022) Sara L. Prescott et al.   NEURON

An inter-organ neural circuit for appetite suppression

(2022) Tong Zhang et al.   CELL

A multidimensional coding architecture of the vagal interoceptive system

(2022) Qiancheng Zhao et al.   NATURE

The neural basis of sugar preference

(2022) Winston W. Liu et al.   NATURE REVIEWS NEUROSCIENCE

Enteroendocrine cell types that drive food reward and aversion

(2022) Ling Bai et al.   eLife

Age-associated gut microbiota impair hippocampus-dependent memory in a vagus-dependent manner

(2022) Damien Rei et al.   JCI Insight

The gut-to-brain axis for toxin-induced defensive responses

(2022) Zhiyong Xie et al.   CELL

Gut–brain circuits for fat preference

(2022) Mengtong Li et al.   NATURE

Hypothalamic detection of macronutrients via multiple gut-brain pathways

(2021) Nitsan Goldstein et al.   Cell Metabolism

Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

(2021) Woo Seok Kim et al.   Nature Communications

The metabolic impact of small intestinal nutrient sensing

(2021) Frank A. Duca et al.   Nature Communications

Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis

(2021) Shiqun Zhang et al.   CELL

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

(2021) Hyo Shin Yoon et al.   Nature Microbiology

Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism

(2021) Diba Borgmann et al.   Cell Metabolism

The cellular and molecular basis of somatosensory neuron development

(2021) Shan Meltzer et al.   NEURON

An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents

(2020) Sara L. Prescott et al.   CELL

Toward Understanding Microbiome-Neuronal Signaling

(2020) K.G. Jameson et al.   MOLECULAR CELL

A neural circuit mechanism for mechanosensory feedback control of ingestion

(2020) Dong-Yoon Kim et al.   NATURE

The gut–brain axis mediates sugar preference

(2020) Hwei-Ee Tan et al.   NATURE

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

(2020) Nick J. Spencer et al.   Nature Reviews Gastroenterology & Hepatology

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

(2020) Madushani Herath et al.   Frontiers in Cellular and Infection Microbiology

Microbiota modulate sympathetic neurons via a gut–brain circuit

(2020) Paul A. Muller et al.   NATURE

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

(2020) Toshiaki Teratani et al.   NATURE

A Vagal-NTS Neural Pathway that Stimulates Feeding

(2020) Jing Chen et al.   CURRENT BIOLOGY

Layers of signals that regulate appetite

(2020) Christopher A Zimmerman et al.   CURRENT OPINION IN NEUROBIOLOGY

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

(2020) Lihua Ye et al.   Cell Host & Microbe

Area Postrema Cell Types that Mediate Nausea-Associated Behaviors

(2020) Chuchu Zhang et al.   NEURON

TLR4 Signaling Selectively and Directly Promotes CGRP Release from Vagal Afferents in the Mouse

(2020) Lin Jia et al.   eNeuro

Pancreatic β-Cells Communicate With Vagal Sensory Neurons

(2020) Madina Makhmutova et al.   GASTROENTEROLOGY

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

(2019) Fiona M. Gribble et al.   Nature Reviews Endocrinology

A gut-to-brain signal of fluid osmolarity controls thirst satiation

(2019) Christopher A. Zimmerman et al.   NATURE

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

(2019) Haiwei Chen et al.   CELL

An Atlas of Vagal Sensory Neurons and Their Molecular Specialization

(2019) Jussi Kupari et al.   Cell Reports

Sour Sensing from the Tongue to the Brain

(2019) Jin Zhang et al.   CELL

Genetic Identification of Vagal Sensory Neurons That Control Feeding

(2019) Ling Bai et al.   CELL

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

(2019) Heping Xu et al.   IMMUNITY

Rethinking Food Reward

(2019) Ivan E. de Araujo et al.   Annual Review of Psychology

Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

(2019) Nicole Y. Lai et al.   CELL

NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways

(2019) Iltan Aklan et al.   Cell Metabolism

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

(2018) Pankaj Baral et al.   NATURE MEDICINE

CGRP as the target of new migraine therapies — successful translation from bench to clinic

(2018) Lars Edvinsson et al.   Nature Reviews Neurology

Microbial regulation of the L cell transcriptome

(2018) Tulika Arora et al.   Scientific Reports

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms

(2018) Kristoffer L. Egerod et al.   Molecular Metabolism

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

(2018) Sigrid Breit et al.   Frontiers in Psychiatry

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System

(2018) Shuohao Sun et al.   CELL

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

(2018) Constanza Alcaino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

(2018) Martina Sgritta et al.   NEURON

The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation

(2017) Kirsteen N. Browning et al.   GASTROENTEROLOGY

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

(2017) Bryan B. Yoo et al.   IMMUNITY

Dynamics of Gut-Brain Communication Underlying Hunger

(2017) Lisa R. Beutler et al.   NEURON

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

(2017) Felipe A. Pinho-Ribeiro et al.   TRENDS IN IMMUNOLOGY

Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity

(2017) Zhenwei Su et al.   Cell Reports

The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract

(2017) Bruno Bonaz et al.   Frontiers in Immunology

SGLT1 sugar transporter/sensor is required for post-oral glucose appetition

(2016) Anthony Sclafani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

Neuro-Immune Interactions at Barrier Surfaces

(2016) Henrique Veiga-Fernandes et al.   CELL

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Striatal Dopamine Links Gastrointestinal Rerouting to Altered Sweet Appetite

(2016) Wenfei Han et al.   Cell Metabolism

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

Thirst neurons anticipate the homeostatic consequences of eating and drinking

(2016) Christopher A. Zimmerman et al.   NATURE

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Separate circuitries encode the hedonic and nutritional values of sugar

(2016) Luis A Tellez et al.   NATURE NEUROSCIENCE

Vagal neurocircuitry and its influence on gastric motility

(2016) R. Alberto Travagli et al.   Nature Reviews Gastroenterology & Hepatology

GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine

(2016) K. Pokusaeva et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Irritable bowel syndrome

(2016) Paul Enck et al.   Nature Reviews Disease Primers

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

The gut connectome: making sense of what you eat

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Thirst driving and suppressing signals encoded by distinct neural populations in the brain

(2015) Yuki Oka et al.   NATURE

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

(2015) M.K. Nøhr et al.   NEUROSCIENCE

Intragastric fat self-administration is impaired in GPR40/120 double knockout mice

(2015) Anthony Sclafani et al.   PHYSIOLOGY & BEHAVIOR

Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses

(2014) Ryo Ikeda et al.   CELL

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Rapid post-oral stimulation of intake and flavor conditioning in rats by glucose but not a non-metabolizable glucose analog

(2014) Karen Ackroff et al.   PHYSIOLOGY & BEHAVIOR

Enteroendocrine cell signalling via the vagus nerve

(2013) Graham J Dockray   CURRENT OPINION IN PHARMACOLOGY

The role of vagal neurocircuits in the regulation of nausea and vomiting

(2013) Tanja Babic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Extrinsic primary afferent signalling in the gut

(2013) Simon J. H. Brookes et al.   Nature Reviews Gastroenterology & Hepatology

The gut as a sensory organ

(2013) John B. Furness et al.   Nature Reviews Gastroenterology & Hepatology

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance

(2012) Harvey J. Grill et al.   Cell Metabolism

The vagus nerve and the inflammatory reflex—linking immunity and metabolism

(2012) Valentin A. Pavlov et al.   Nature Reviews Endocrinology

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose

(2012) Michael M. Scott et al.   PLoS One

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

Intestinal glucose-induced calcium-calmodulin kinase signaling in the gut-brain axis in awake rats

(2011) K. M. Vincent et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The microbiome-gut-brain axis: from bowel to behavior

(2011) J. F. Cryan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Flavor preferences conditioned by post-oral infusion of monosodium glutamate in rats

(2011) Karen Ackroff et al.   PHYSIOLOGY & BEHAVIOR

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of basal pseudopod-like processes in ileal and colonic PYY cells

(2010) Diego V. Bohórquez et al.   JOURNAL OF MOLECULAR HISTOLOGY

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Post-oral infusion sites that support glucose-conditioned flavor preferences in rats

(2009) Karen Ackroff et al.   PHYSIOLOGY & BEHAVIOR

Identification of functional intramuscular rectal mechanoreceptors in aganglionic rectal smooth muscle from piebald lethal mice

(2008) Nick J. Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

(2008) Q. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production

(2008) Penny Y. T. Wang et al.   NATURE

The vagus nerve, food intake and obesity

(2008) Hans-Rudolf Berthoud   REGULATORY PEPTIDES

Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior

(2007) Lisa E. Goehler et al.   BRAIN BEHAVIOR AND IMMUNITY