Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

(2020) Mari Lilith Lund et al.   DIABETES

A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice

(2020) Lijuan Wang et al.   GUT

Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice

(2020) Clara Depommier et al.   Gut Microbes

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

(2019) Fiona M. Gribble et al.   Nature Reviews Endocrinology

Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement

(2019) Maria Carlota Dao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

(2019) Eduard Ansaldo et al.   SCIENCE

2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2019) John B. Buse et al.   DIABETES CARE

Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats

(2018) Jean-Philippe Krieger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

(2018) Louise Lang Lehrskov et al.   Cell Metabolism

CREB/CRTC2 controls GLP-1–dependent regulation of glucose homeostasis

(2018) Ji-Hyun Lee et al.   FASEB JOURNAL

Quantitative proteomic analysis identifies AHNAK as a novel candidate biomarker for bladder urothelial carcinoma diagnosis by liquid-based cytology

(2018) Hyebin Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Gut microbiota utilize immunoglobulin A for mucosal colonization

(2018) G. P. Donaldson et al.   SCIENCE

Akkermansia muciniphila can reduce the damage of gluco/lipotoxicity, oxidative stress and inflammation, and normalize intestine microbiota in streptozotocin-induced diabetic rats

(2018) Ling Zhang et al.   Pathogens and Disease

Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery

(2018) Vance L. Albaugh et al.   GASTROENTEROLOGY

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

(2017) Zhuang Li et al.   GUT

Gypenosides Reduced the Risk of Overweight and Insulin Resistance in C57BL/6J Mice through Modulating Adipose Thermogenesis and Gut Microbiota

(2017) Jie Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gq and Gs signaling acting in synergy to control GLP-1 secretion

(2017) Maria Hauge et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

(2017) Lorène J. Lebrun et al.   Cell Reports

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

(2017) Noora Ottman et al.   PLoS One

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

(2016) Lydia Lynch et al.   Cell Metabolism

The effect of heritability and host genetics on the gut microbiota and metabolic syndrome

(2016) Mi Young Lim et al.   GUT

Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor γ in Adipogenesis

(2016) Young-Kwon Park et al.   MOLECULAR AND CELLULAR BIOLOGY

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Mucin-munching bacteria modulate glucose metabolism

(2016) Tim Geach   Nature Reviews Endocrinology

Characterization of Outer Membrane Proteome of Akkermansia muciniphila Reveals Sets of Novel Proteins Exposed to the Human Intestine

(2016) Noora Ottman et al.   Frontiers in Microbiology

Microbial regulation of GLP-1 and L-cell biology

(2016) Thomas U. Greiner et al.   Molecular Metabolism

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Endocannabinoids — at the crossroads between the gut microbiota and host metabolism

(2015) Patrice D. Cani et al.   Nature Reviews Endocrinology

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease

(2015) Parth J Parekh et al.   Clinical and Translational Gastroenterology

Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

(2014) Rune E. Kuhre et al.   DIABETES

GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6-Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering

(2014) F. Kahles et al.   DIABETES

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

(2014) Catalin Chimerel et al.   Cell Reports

Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders

(2014) N Tennoune et al.   Translational Psychiatry

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S

(2014) Vanitha Bala et al.   Frontiers in Physiology

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

(2014) Soona Shin et al.   Molecular Metabolism

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion

(2013) Hariom Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Ligand-based receptor identification on living cells and tissues using TRICEPS

(2013) Andreas P Frei et al.   Nature Protocols

Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis

(2013) Chil-sung Kang et al.   PLoS One

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct identification of ligand-receptor interactions on living cells and tissues

(2012) Andreas P Frei et al.   NATURE BIOTECHNOLOGY

The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight

(2012) Caroline L.J. Karlsson et al.   Obesity

Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

(2012) Trond Ulven   Frontiers in Endocrinology

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

(2011) Amandine Everard et al.   DIABETES

Metabolomics of Fecal Extracts Detects Altered Metabolic Activity of Gut Microbiota in Ulcerative Colitis and Irritable Bowel Syndrome

(2011) Gwénaëlle Le Gall et al.   JOURNAL OF PROTEOME RESEARCH

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women

(2010) A. Santacruz et al.   BRITISH JOURNAL OF NUTRITION

Interleukin-6 Signaling in Liver-Parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action

(2010) F. Thomas Wunderlich et al.   Cell Metabolism