CGRP as the target of new migraine therapies — successful translation from bench to clinic
出版年份 2018 全文链接
标题
CGRP as the target of new migraine therapies — successful translation from bench to clinic
作者
关键词
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出版物
Nature Reviews Neurology
Volume 14, Issue 6, Pages 338-350
出版商
Springer Nature
发表日期
2018-04-24
DOI
10.1038/s41582-018-0003-1
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Side effects associated with current and prospective antimigraine pharmacotherapies
- (2017) Abimael González-Hernández et al. Expert Opinion on Drug Metabolism & Toxicology
- The safety and efficacy of the 5-HT 1F receptor agonist lasmiditan in the acute treatment of migraine
- (2017) Bianca Raffaelli et al. EXPERT OPINION ON PHARMACOTHERAPY
- Overview of Neuropeptides: Awakening the Senses?
- (2017) Andrew F. Russo HEADACHE
- The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine
- (2017) Lars Edvinsson HEADACHE
- Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca2+ levels in the perfused and non-perfused isolated rat middle cerebral artery
- (2017) André Erdling et al. JOURNAL OF HEADACHE AND PAIN
- An update on migraine: current understanding and future directions
- (2017) Francesca Puledda et al. JOURNAL OF NEUROLOGY
- Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody
- (2017) Agustin Melo-Carrillo et al. JOURNAL OF NEUROSCIENCE
- Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2017) Theo Vos et al. LANCET
- Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial
- (2017) Stewart Tepper et al. LANCET NEUROLOGY
- The Role of 5-Hydroxytryptamine in the Pathophysiology of Migraine and its Relevance to the Design of Novel Treatments
- (2017) Carlos M. Villalón et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Understanding migraine as a cycling brain syndrome: reviewing the evidence from functional imaging
- (2017) Arne May NEUROLOGICAL SCIENCES
- Erenumab (AMG 334) in episodic migraine
- (2017) Messoud Ashina et al. NEUROLOGY
- Fremanezumab for the Preventive Treatment of Chronic Migraine
- (2017) Stephen D. Silberstein et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Controlled Trial of Erenumab for Episodic Migraine
- (2017) Peter J. Goadsby et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pathophysiology of Migraine: A Disorder of Sensory Processing
- (2017) Peter J. Goadsby et al. PHYSIOLOGICAL REVIEWS
- Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries
- (2017) Majid Sheykhzade et al. VASCULAR PHARMACOLOGY
- Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles
- (2016) Debbie L. Hay et al. Annual Review of Pharmacology and Toxicology
- Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis
- (2016) Robin M van Dongen et al. CEPHALALGIA
- A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine
- (2016) Tiffini Voss et al. CEPHALALGIA
- TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP
- (2016) Marina Quartu et al. JOURNAL OF ANATOMY
- Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial
- (2016) Hong Sun et al. LANCET NEUROLOGY
- New strategies for the treatment and prevention of primary headache disorders
- (2016) Nathaniel M. Schuster et al. Nature Reviews Neurology
- TEV-48125 for the preventive treatment of chronic migraine
- (2016) Marcelo E. Bigal et al. NEUROLOGY
- Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies
- (2016) Silke Miller et al. NEUROSCIENCE
- Wiping Out CGRP: Potential Cardiovascular Risks
- (2016) Antoinette MaassenVanDenBrink et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood–brain barrier
- (2015) Sajedeh Eftekhari et al. BRAIN RESEARCH
- Therapeutic antibodies against CGRP or its receptor
- (2015) Marcelo E. Bigal et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment
- (2015) Lars Edvinsson BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The Journey to Establish CGRP as a Migraine Target: A Retrospective View
- (2015) Lars Edvinsson HEADACHE
- Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography
- (2015) Sajedeh Eftekhari et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Dural administration of inflammatory soup or Complete Freund’s Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion
- (2015) M. Lukács et al. JOURNAL OF HEADACHE AND PAIN
- Experimental inflammation following dural application of complete Freund’s adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage
- (2015) Cornelia Lundblad et al. JOURNAL OF HEADACHE AND PAIN
- Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study
- (2015) Marcelo E Bigal et al. LANCET NEUROLOGY
- Calcitonin Gene-Related Peptide Receptor Antagonists: New Therapeutic Agents for Migraine
- (2014) Ian M. Bell JOURNAL OF MEDICINAL CHEMISTRY
- Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study
- (2014) David W Dodick et al. LANCET NEUROLOGY
- Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial
- (2014) David W Dodick et al. LANCET NEUROLOGY
- Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
- (2014) F. A. Russell et al. PHYSIOLOGICAL REVIEWS
- Migraine: The seventh disabler
- (2013) TJ Steiner et al. CEPHALALGIA
- BMS-927711 for the acute treatment of migraine: A double-blind, randomized, placebo controlled, dose-ranging trial
- (2013) Ronald Marcus et al. CEPHALALGIA
- Differentiation of Nerve Fibers Storing CGRP and CGRP Receptors in the Peripheral Trigeminovascular System
- (2013) Sajedeh Eftekhari et al. JOURNAL OF PAIN
- Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study
- (2013) Faisal Mohammad Amin et al. LANCET NEUROLOGY
- Analysis of the proteolysis of bioactive peptides using a peptidomics approach
- (2013) Yun-Gon Kim et al. Nature Protocols
- Pathophysiology of Migraine
- (2012) Daniela Pietrobon et al. Annual Review of Physiology
- Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level
- (2012) Sajedeh Eftekhari et al. BMC NEUROSCIENCE
- Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF
- (2012) Jan Hoffmann et al. CEPHALALGIA
- Direct Interactions between Calcitonin-Like Receptor (CLR) and CGRP-Receptor Component Protein (RCP) Regulate CGRP Receptor Signaling
- (2012) Sophie C. Egea et al. ENDOCRINOLOGY
- Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
- (2012) Isaac M Chiu et al. NATURE NEUROSCIENCE
- Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults: Table 1
- (2012) S.D. Silberstein et al. NEUROLOGY
- mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene–related peptide in the rat trigeminovascular system
- (2012) Dipak V. Amrutkar et al. PAIN
- Basic mechanisms of migraine and its acute treatment
- (2012) Lars Edvinsson et al. PHARMACOLOGY & THERAPEUTICS
- Adherence with Migraine Prophylaxis in Clinical Practice
- (2012) Ariel Berger et al. Pain Practice
- Tracing neural connections to pain pathways with relevance to primary headaches
- (2011) Lars Edvinsson CEPHALALGIA
- Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine
- (2011) David J Hewitt et al. CEPHALALGIA
- Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects
- (2011) Alice De Corato et al. JOURNAL OF NEUROIMMUNOLOGY
- Calcitonin Gene-Related Peptide-Mediated Enhancement of Purinergic Neuron/Glia Communication by the Algogenic Factor Bradykinin in Mouse Trigeminal Ganglia from Wild-Type and R192Q Cav2.1 Knock-In Mice: Implications for Basic Mechanisms of Migraine Pain
- (2011) S. Ceruti et al. JOURNAL OF NEUROSCIENCE
- Diencephalic and brainstem mechanisms in migraine
- (2011) Simon Akerman et al. NATURE REVIEWS NEUROSCIENCE
- Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin D2 (PGD2)
- (2010) Troels Wienecke et al. CEPHALALGIA
- Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries
- (2010) Lars Edvinsson et al. CEPHALALGIA
- Measurement of vasoactive neuropeptides in biological materials: Problems and pitfalls from 30 years of experience and novel future approaches
- (2010) Lars Edvinsson et al. CEPHALALGIA
- BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study
- (2010) Hans-Christoph Diener et al. CEPHALALGIA
- Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura
- (2010) Jakob Møller Hansen et al. CEPHALALGIA
- New drugs in migraine treatment and prophylaxis: telcagepant and topiramate
- (2010) Lars Edvinsson et al. LANCET
- CGRP and its receptors provide new insights into migraine pathophysiology
- (2010) Tony W. Ho et al. Nature Reviews Neurology
- Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
- (2010) S. Eftekhari et al. NEUROSCIENCE
- Plasma and saliva levels of nerve growth factor and neuropeptides in chronic migraine patients
- (2010) M-U Jang et al. ORAL DISEASES
- Possible sites of action of the new calcitonin gene-related peptide receptor antagonists
- (2010) Sajedeh Eftekhari et al. Therapeutic Advances in Neurological Disorders
- Brainstem and Thalamic Projections from a Craniovascular Sensory Nervous Centre in the Rostral Cervical Spinal Dorsal Horn of Rats
- (2009) Y Liu et al. CEPHALALGIA
- Elevated Saliva Calcitonin Gene-Related Peptide Levels During Acute Migraine Predict Therapeutic Response to Rizatriptan
- (2009) Roger K. Cady et al. HEADACHE
- CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways
- (2009) C. V. Vause et al. JOURNAL OF NEUROCHEMISTRY
- Proinflammatory-Activated Trigeminal Satellite Cells Promote Neuronal Sensitization: Relevance for Migraine Pathology
- (2009) Alessandro Capuano et al. Molecular Pain
- Randomized, controlled trial of telcagepant for the acute treatment of migraine
- (2009) K. M. Connor et al. NEUROLOGY
- The vascular theory of migraine—a great story wrecked by the facts
- (2008) Peter J. Goadsby BRAIN
- Central projections of the sensory innervation of the rat middle meningeal artery
- (2008) Yi Liu et al. BRAIN RESEARCH
- Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells
- (2008) Jing Li et al. BRAIN RESEARCH
- The Blood-Brain Barrier in Migraine Treatment
- (2008) L Edvinsson et al. CEPHALALGIA
- Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
- (2008) Jochen K. Lennerz et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial
- (2008) Tony W Ho et al. LANCET
- Inhibitory effect of BIBN4096BS, CGRP8-37, a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery
- (2007) L Edvinsson et al. BRITISH JOURNAL OF PHARMACOLOGY
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