The microbiome and innate immunity

Taking it Personally: Personalized Utilization of the Human Microbiome in Health and Disease

(2016) Niv Zmora et al.   Cell Host & Microbe

Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease

(2016) Karishma Kamdar et al.   Cell Host & Microbe

Modulating the Gut Microbiota Improves Glucose Tolerance, Lipoprotein Profile and Atherosclerotic Plaque Development in ApoE-Deficient Mice

(2016) Ida Rune et al.   PLoS One

Transkingdom control of viral infection and immunity in the mammalian intestine

(2016) J. K. Pfeiffer et al.   SCIENCE

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Integration of Innate Immune Signaling

(2016) Christoph A. Thaiss et al.   TRENDS IN IMMUNOLOGY

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

(2015) Denise Morais da Fonseca et al.   CELL

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

(2015) Aleksandar D. Kostic et al.   Cell Host & Microbe

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

(2015) Vanessa Leone et al.   Cell Host & Microbe

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche

(2015) Yubin Luo et al.   Cell Metabolism

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street

(2015) David M. Underhill et al.   IMMUNITY

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota

(2015) Xiaohuan Guo et al.   IMMUNITY

Epithelial NAIPs protect against colonic tumorigenesis

(2015) Ramanjaneyulu Allam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

(2015) Shruti Naik et al.   NATURE

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Analysis of gene–environment interactions in postnatal development of the mammalian intestine

(2015) Seth Rakoff-Nahoum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells

(2015) M. R. Hepworth et al.   SCIENCE

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

(2015) Shuiqing Hu et al.   Cell Reports

Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome

(2015) Maayan Levy et al.   Genome Medicine

Site-specific programming of the host epithelial transcriptome by the gut microbiota

(2015) Felix Sommer et al.   GENOME BIOLOGY

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

Exploring New Horizons in Microbiome Research

(2014) Christoph A. Thaiss et al.   Cell Host & Microbe

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

The Cytosolic Bacterial Peptidoglycan Sensor Nod2 Affords Stem Cell Protection and Links Microbes to Gut Epithelial Regeneration

(2014) Giulia Nigro et al.   Cell Host & Microbe

Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

(2014) Yun-Gi Kim et al.   Cell Host & Microbe

Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome

(2014) Amir Zarrinpar et al.   Cell Metabolism

Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape

(2014) J. Gray Camp et al.   GENOME RESEARCH

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

(2014) Judith Behnsen et al.   IMMUNITY

Mining the Human Gut Microbiota for Effector Strains that Shape the Immune System

(2014) Philip P. Ahern et al.   IMMUNITY

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

(2014) Maria L. Balmer et al.   JOURNAL OF IMMUNOLOGY

The Multifaceted Role of the Intestinal Microbiota in Colon Cancer

(2014) Thergiory Irrazábal et al.   MOLECULAR CELL

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease

(2014) Sebastian Zeissig et al.   NATURE IMMUNOLOGY

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

(2014) Lukas Schwab et al.   NATURE MEDICINE

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

(2014) Hitesh S Deshmukh et al.   NATURE MEDICINE

Commensal bacteria protect against food allergen sensitization

(2014) A. T. Stefka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Commensal microbes and interferon-  determine persistence of enteric murine norovirus infection

(2014) M. T. Baldridge et al.   SCIENCE

Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

(2014) B. Zhang et al.   SCIENCE

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

Diet-Induced Alterations in Gut Microflora Contribute to Lethal Pulmonary Damage in TLR2/TLR4-Deficient Mice

(2014) Yewei Ji et al.   Cell Reports

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

(2014) Catalin Chimerel et al.   Cell Reports

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

(2013) Atish Mukherji et al.   CELL

Innate Immune Receptors: Key Regulators of Metabolic Disease Progression

(2013) Chengcheng Jin et al.   Cell Metabolism

The interplay between the innate immune system and the microbiota

(2013) Christoph A Thaiss et al.   CURRENT OPINION IN IMMUNOLOGY

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis

(2013) Lionel Rigottier-Gois   ISME Journal

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

(2013) Wei Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

(2013) Theresa Alenghat et al.   NATURE

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells

(2013) Gretchen E. Diehl et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

Nonredundant Function of Soluble LT 3 Produced by Innate Lymphoid Cells in Intestinal Homeostasis

(2013) A. A. Kruglov et al.   SCIENCE

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

(2012) Hachung Chung et al.   CELL

Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

(2012) Frederic A. Carvalho et al.   Cell Host & Microbe

Innate immune signalling at the intestinal epithelium in homeostasis and disease

(2012) Johanna Pott et al.   EMBO REPORTS

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

(2012) Nick Powell et al.   IMMUNITY

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Innate Lymphoid Cell Interactions with Microbiota: Implications for Intestinal Health and Disease

(2012) Gregory F. Sonnenberg et al.   IMMUNITY

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice

(2012) Carles Ubeda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation

(2012) David A Hill et al.   NATURE MEDICINE

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota

(2012) N. Kamada et al.   SCIENCE

Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

(2012) I. D. Iliev et al.   SCIENCE

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Epigenetic Control of the Host Gene by Commensal Bacteria in Large Intestinal Epithelial Cells

(2011) Kyoko Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

(2011) G. Y. Chen et al.   JOURNAL OF IMMUNOLOGY

A unique homologue of the eukaryotic protein-modifier ubiquitin present in the bacterium Bacteroides fragilis, a predominant resident of the human gastrointestinal tract

(2011) S. Patrick et al.   MICROBIOLOGY-SGM

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

(2011) S. Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Successful Transmission of a Retrovirus Depends on the Commensal Microbiota

(2011) M. Kane et al.   SCIENCE

Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis

(2011) S. K. Kuss et al.   SCIENCE

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE