Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

(2019) Van B. Lu et al.   Nature Communications

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

(2019) Geoffrey P. Roberts et al.   DIABETES

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

(2018) Charlotte Bayer Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeting the Incretin/Glucagon System with Triagonists to Treat Diabetes

(2018) Megan E Capozzi et al.   ENDOCRINE REVIEWS

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

(2018) Joep Beumer et al.   NATURE CELL BIOLOGY

Glucagon-like peptide 1 in health and disease

(2018) Andreas Andersen et al.   Nature Reviews Endocrinology

Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery

(2018) Geoffrey P. Roberts et al.   Surgery for Obesity and Related Diseases

β-Oxidation in ghrelin-producing cells is important for ghrelin acyl-modification

(2018) Chika Ikenoya et al.   Scientific Reports

Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites

(2018) Mari L. Lund et al.   Molecular Metabolism

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

(2018) Rune E. Kuhre et al.   Molecular Metabolism

Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

(2018) Deborah A. Goldspink et al.   Molecular Metabolism

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial

(2018) Patrick M O'Neil et al.   LANCET

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

SCFAs strongly stimulate PYY production in human enteroendocrine cells

(2018) P. Larraufie et al.   Scientific Reports

Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells

(2018) Lawrence J. Billing et al.   Molecular Metabolism

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

(2018) Juan Pablo Frias et al.   LANCET

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

(2018) Piotr A. Mroz et al.   Molecular Metabolism

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

(2018) Tamer Coskun et al.   Molecular Metabolism

The Diverse Metabolic Roles of Peripheral Serotonin

(2017) Alyce M. Martin et al.   ENDOCRINOLOGY

Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice

(2017) Akiko Sankoda et al.   ENDOCRINOLOGY

Costorage of Enteroendocrine Hormones Evaluated at the Cell and Subcellular Levels in Male Mice

(2017) Linda J. Fothergill et al.   ENDOCRINOLOGY

The Effect of a Subcutaneous Infusion of GLP-1, OXM, and PYY on Energy Intake and Expenditure in Obese Volunteers

(2017) Tricia Tan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion

(2017) Monika Saltiel et al.   Nutrients

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion

(2017) Lorène J. Lebrun et al.   Cell Reports

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

(2017) Lucy Brooks et al.   Molecular Metabolism

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

(2016) Dorien Reijnders et al.   Cell Metabolism

TLR ligands and butyrate increasePyyexpression through two distinct but inter-regulated pathways

(2016) Pierre Larraufie et al.   CELLULAR MICROBIOLOGY

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia

(2016) Rodolphe Dusaulcy et al.   ENDOCRINOLOGY

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism

(2016) Kaare V. Grunddal et al.   ENDOCRINOLOGY

β-Cell Glucagon-Like Peptide-1 Receptor Contributes to Improved Glucose Tolerance After Vertical Sleeve Gastrectomy

(2016) Darline Garibay et al.   ENDOCRINOLOGY

Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery

(2016) M S Svane et al.   INTERNATIONAL JOURNAL OF OBESITY

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells

(2016) Paul Richards et al.   PEPTIDES

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells

(2016) Ramona Pais et al.   PEPTIDES

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells

(2016) Catherine E. Moss et al.   PEPTIDES

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production

(2016) Ying Shiuan Lee et al.   Molecular Metabolism

The insulinotrophic effect of insulin-like peptide 5in vitroandin vivo

(2015) Xiao Luo et al.   BIOCHEMICAL JOURNAL

GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study

(2015) Kristine Færch et al.   DIABETES

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

(2015) Nicolai A. Rhee et al.   DIABETOLOGIA

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults

(2015) Hannah B. Lewis et al.   Obesity

Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel

(2015) Hui-Ren Zhou et al.   TOXICOLOGICAL SCIENCES

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism

(2015) Kristian H. Mikkelsen et al.   PLoS One

Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

(2014) Rune E. Kuhre et al.   DIABETES

Stimulation of GLP-1 Secretion Downstream of the Ligand-Gated Ion Channel TRPA1

(2014) Edward C. Emery et al.   DIABETES

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

(2014) TinaMarie Lieu et al.   GASTROENTEROLOGY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Gastric emptying and glycaemia in health and diabetes mellitus

(2014) Liza K. Phillips et al.   Nature Reviews Endocrinology

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

(2014) J. Grosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

(2014) Catalin Chimerel et al.   Cell Reports

G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro

(2013) Zhi Gong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-Like Peptide-2

(2013) Daniel J. Drucker et al.   Annual Review of Physiology

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Enteroendocrine hormones—central effects on behavior

(2013) Karolina P Skibicka et al.   CURRENT OPINION IN PHARMACOLOGY

Gut motility and enteroendocrine secretion

(2013) Tongzhi Wu et al.   CURRENT OPINION IN PHARMACOLOGY

Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes

(2013) Nils B. Jørgensen et al.   DIABETES

Generation of L Cells in Mouse and Human Small Intestine Organoids

(2013) N. Petersen et al.   DIABETES

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

(2013) H. E. Wilson-Perez et al.   DIABETES

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

(2013) Eleftheria Diakogiannaki et al.   DIABETOLOGIA

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

(2013) Mark K. Nøhr et al.   ENDOCRINOLOGY

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

(2013) Maja S. Engelstoft et al.   Molecular Metabolism

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells

(2012) Ichiro Sakata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance

(2012) N. B. Jørgensen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice

(2012) Xinping Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men

(2012) Ixchel M. Brennan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

G-Protein-Coupled Receptors in Intestinal Chemosensation

(2012) Frank Reimann et al.   Cell Metabolism

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion

(2012) H. E. Parker et al.   DIABETOLOGIA

A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

(2012) Kristoffer L. Egerod et al.   ENDOCRINOLOGY

Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry

(2012) Abdella M. Habib et al.   ENDOCRINOLOGY

The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor Is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells

(2012) Manami Oya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine

(2012) Oliver J. Mace et al.   JOURNAL OF PHYSIOLOGY-LONDON

Roux-en-Y gastric bypass surgery increases number but not density of CCK-, GLP-1-, 5-HT-, and neurotensin-expressing enteroendocrine cells in rats

(2012) M. B. Mumphrey et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Duodenal Enteroendocrine I-Cells Contain mRNA Transcripts Encoding Key Endocannabinoid and Fatty Acid Receptors

(2012) Alexandros G. Sykaras et al.   PLoS One

The gut endocrine system as a coordinator of postprandial nutrient homoeostasis

(2012) Fiona M. Gribble   PROCEEDINGS OF THE NUTRITION SOCIETY

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

(2011) V. Gorboulev et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Longevity of human islet α- and β-cells

(2011) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

(2011) E. L. Lim et al.   DIABETOLOGIA

Luminal Amino Acid-Sensing Cells in Gastric Mucosa

(2011) Eiji Nakamura et al.   DIGESTION

Electrical activity-triggered glucagon-like peptide-1 secretion from primary murine L-cells

(2011) G. J. Rogers et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide

(2011) Scott E. Kanoski et al.   NEUROPHARMACOLOGY

Ghrelin secretion stimulated by  1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Fat Hydrolysis in Regulating Glucagon-Like Peptide-1 Secretion

(2009) Svetlana Beglinger et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cholecystokinin and gut–brain signalling

(2009) Graham J. Dockray   REGULATORY PEPTIDES

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo

(2008) Yukihiro Fujita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

(2008) H. E. Parker et al.   DIABETOLOGIA