Plasma membrane repair empowers the necrotic survivors as innate immune modulators

Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair

(2023) Xinan Meng et al.   JOURNAL OF CELL BIOLOGY

Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis

(2022) Weihong Wang et al.   DEVELOPMENTAL CELL

Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry

(2022) Ana Beatriz Santa Cruz Garcia et al.   Nature Communications

Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion

(2022) Johannes Westman et al.   Cell Reports

Optogenetic activators of apoptosis, necroptosis, and pyroptosis

(2022) Kateryna Shkarina et al.   JOURNAL OF CELL BIOLOGY

Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair

(2022) Yuwei Huang et al.   NATURE CELL BIOLOGY

ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack

(2022) Alex T. Ritter et al.   SCIENCE

Recruitment of tetraspanin TSP-15 to epidermal wounds promotes plasma membrane repair in C. elegans

(2022) Yuanyuan Wang et al.   DEVELOPMENTAL CELL

Caspase-7 activates ASM to repair gasdermin and perforin pores

(2022) Kengo Nozaki et al.   NATURE

Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response

(2022) Zhaoting Li et al.   Nature Communications

Mitochondrial fragmentation and ROS signaling in wound response and repair

(2022) Shiqi Xu et al.   Cell Regeneration

Plasma membrane integrity in health and disease: significance and therapeutic potential

(2021) Catarina Dias et al.   Cell Discovery

Sealing holes in cellular membranes

(2021) Yan Zhen et al.   EMBO JOURNAL

Plasma membrane integrity: implications for health and disease

(2021) Dustin A. Ammendolia et al.   BMC BIOLOGY

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

(2021) Jin Young Baik et al.   Nature Communications

Regulation of lytic and non-lytic functions of gasdermin pores

(2021) Sebastian Rühl et al.   JOURNAL OF MOLECULAR BIOLOGY

Redox-sensitive CDC-42 clustering promotes wound closure in C. elegans

(2021) Jingxiu Xu et al.   Cell Reports

Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling

(2020) Hongying Fu et al.   Nature Communications

Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans

(2020) Xinan Meng et al.   DEVELOPMENTAL CELL

Endophilin-A2 dependent tubular endocytosis promotes plasma membrane repair and parasite invasion

(2020) Matthias Corrotte et al.   JOURNAL OF CELL SCIENCE

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

(2020) Lohans Pedrera et al.   CELL DEATH AND DIFFERENTIATION

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

(2019) Weiliang Fan et al.   Science Signaling

Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains

(2019) Yuwei Huang et al.   NATURE CELL BIOLOGY

ESCRT-III–dependent membrane repair blocks ferroptosis

(2019) Enyong Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes

(2019) Guillermo Montalban-Bravo et al.   LEUKEMIA

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein

(2018) Prashant Bharadwaj et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis

(2018) Delong Jiao et al.   CELL RESEARCH

Plasma membrane repair

(2018) Norma W. Andrews et al.   CURRENT BIOLOGY

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Structure of the human PKD1-PKD2 complex

(2018) Qiang Su et al.   SCIENCE

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

(2018) Hui Chen et al.   Cell Death & Disease

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer

(2018) Ayaz Najafov et al.   PLOS BIOLOGY

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

(2018) John McCullough et al.   Annual Review of Cell and Developmental Biology

To the edge of cell death and back

(2018) Yi-Nan Gong et al.   FEBS Journal

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Necroptosis: (Last) Message in a Bubble

(2017) Peter Vandenabeele et al.   IMMUNITY

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

A molecular signature for anastasis, recovery from the brink of apoptotic cell death

(2017) Gongping Sun et al.   JOURNAL OF CELL BIOLOGY

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

(2017) Gui-Wei He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

(2017) Amulya Nidhi Shrivastava et al.   NEURON

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion

(2017) Mikkel Roland Holst et al.   Cell Reports

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

The early wound signals

(2016) Philipp Niethammer   CURRENT OPINION IN GENETICS & DEVELOPMENT

An actin-dependent annexin complex mediates plasma membrane repair in muscle

(2016) Alexis R. Demonbreun et al.   JOURNAL OF CELL BIOLOGY

Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway

(2016) J Xin et al.   LEUKEMIA

Membrane dynamics during cellular wound repair

(2016) Nicholas R. Davenport et al.   MOLECULAR BIOLOGY OF THE CELL

Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

(2016) Ryan J. Cummings et al.   NATURE

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Co-option of Membrane Wounding Enables Virus Penetration into Cells

(2015) Stefania Luisoni et al.   Cell Host & Microbe

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle

(2015) Harriet P. Lo et al.   JOURNAL OF CELL BIOLOGY

Membrane Repair: Mechanisms and Pathophysiology

(2015) Sandra T. Cooper et al.   PHYSIOLOGICAL REVIEWS

Cell healing: Calcium, repair and regeneration

(2015) Alison M. Moe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

C. elegans Epidermal Wounding Induces a Mitochondrial ROS Burst that Promotes Wound Repair

(2014) Suhong Xu et al.   DEVELOPMENTAL CELL

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1  Released from Dying Cells

(2014) T. Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string

(2012) M. T. Abreu-Blanco et al.   JOURNAL OF CELL SCIENCE

Spatiotemporal dynamics of actin remodeling and endomembrane trafficking in alveolar epithelial type I cell wound healing

(2011) Lindsay M. Godin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

RAB-5- and RAB-11-Dependent Vesicle-Trafficking Pathways Are Required for Plasma Membrane Repair after Attack by Bacterial Pore-Forming Toxin

(2011) Ferdinand C.O. Los et al.   Cell Host & Microbe

A Gαq-Ca2+ Signaling Pathway Promotes Actin-Mediated Epidermal Wound Closure in C. elegans

(2011) Suhong Xu et al.   CURRENT BIOLOGY

Cell wound repair inDrosophilaoccurs through three distinct phases of membrane and cytoskeletal remodeling

(2011) Maria Teresa Abreu-Blanco et al.   JOURNAL OF CELL BIOLOGY

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair

(2011) Anthony Bouter et al.   Nature Communications

Resistance to Caspase-Independent Cell Death Requires Persistence of Intact Mitochondria

(2010) Stephen W.G. Tait et al.   DEVELOPMENTAL CELL

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

(2010) Christina Tam et al.   JOURNAL OF CELL BIOLOGY

Mechanics of cytokinesis in eukaryotes

(2009) Thomas D Pollard   CURRENT OPINION IN CELL BIOLOGY

Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase

(2009) A. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

(2009) María Yáñez-Mó et al.   TRENDS IN CELL BIOLOGY

Distinct Innate Immune Responses to Infection and Wounding in the C. elegans Epidermis

(2008) Nathalie Pujol et al.   CURRENT BIOLOGY

Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis

(2008) Matthias Husmann et al.   FEBS LETTERS

The role of annexins in tumour development and progression

(2008) S Mussunoor et al.   JOURNAL OF PATHOLOGY

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY