Optogenetic activators of apoptosis, necroptosis, and pyroptosis

Pulsatile contractions promote apoptotic cell extrusion in epithelial tissues

(2021) Youmna Atieh et al.   CURRENT BIOLOGY

Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion

(2021) Anh Phuong Le et al.   Nature Communications

Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion

(2021) Kinga Duszyc et al.   CURRENT BIOLOGY

Light‐Driven Cascade Mitochondria‐to‐Nucleus Photosensitization in Cancer Cell Ablation

(2021) Kang‐Nan Wang et al.   Advanced Science

Apoptotic cell extrusion depends on single-cell synthesis of sphingosine-1-phosphate by sphingosine kinase 2

(2021) Bruno Jaime Santacreu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Optogenetic Control of Non‐Apoptotic Cell Death

(2021) Lian He et al.   Advanced Science

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

(2021) Paolo Armando Gagliardi et al.   DEVELOPMENTAL CELL

Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement

(2020) Seokhwi Kim et al.   Science Advances

RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif

(2020) Hong Hu et al.   CELL DEATH AND DIFFERENTIATION

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11

(2020) Betsaida Bibo-Verdugo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

(2020) Andre L. Samson et al.   Nature Communications

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

(2020) Nathalia Moraes de Vasconcelos et al.   Cell Reports

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

(2020) Rosalie Heilig et al.   Life Science Alliance

Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion

(2020) Jessica L. Teo et al.   MOLECULAR BIOLOGY OF THE CELL

The Coming Decade of Cell Death Research: Five Riddles

(2019) Douglas R. Green   CELL

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Zebrafish in Inflammasome Research

(2019) Gabriel Forn-Cuní et al.   Cells

The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis

(2019) Jiang-Yuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Green monomeric photosensitizing fluorescent protein for photo-inducible protein inactivation and cell ablation

(2018) Yemima Dani Riani et al.   BMC BIOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

(2018) Shizue Ohsawa et al.   DEVELOPMENTAL CELL

Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis

(2018) Scott P. Davies et al.   Frontiers in Immunology

Anastasis: recovery from the brink of cell death

(2018) Ho Man Tang et al.   Royal Society Open Science

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

(2017) Isabella Rauch et al.   IMMUNITY

MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion

(2017) Paolo Armando Gagliardi et al.   JOURNAL OF CELL BIOLOGY

Dynamics of in vivo ASC speck formation

(2017) Paola Kuri et al.   JOURNAL OF CELL BIOLOGY

Engineering a light-activated caspase-3 for precise ablation of neurons in vivo

(2017) Ashley D. Smart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The clearance of dying cells: table for two

(2016) D R Green et al.   CELL DEATH AND DIFFERENTIATION

ASC filament formation serves as a signal amplification mechanism for inflammasomes

(2016) Mathias S. Dick et al.   Nature Communications

Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG

(2016) Suhong Xu et al.   Scientific Reports

An open-hardware platform for optogenetics and photobiology

(2016) Karl P. Gerhardt et al.   Scientific Reports

Optogenetic Apoptosis: Light-Triggered Cell Death

(2015) Robert M. Hughes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Osmotic surveillance mediates rapid wound closure through nucleotide release

(2014) William J. Gault et al.   JOURNAL OF CELL BIOLOGY

Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours

(2014) D. Kuipers et al.   JOURNAL OF CELL SCIENCE

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

An optimized optogenetic clustering tool for probing protein interaction and function

(2014) Amir Taslimi et al.   Nature Communications

The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells

(2014) Tessa Gargett et al.   Frontiers in Pharmacology

Wnt/Dkk Negative Feedback Regulates Sensory Organ Size in Zebrafish

(2013) Hironori Wada et al.   CURRENT BIOLOGY

Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage

(2013) Jiao Zhang et al.   Nature Communications

Rapid and Permanent Neuronal Inactivation In Vivo via Subcellular Generation of Reactive Oxygen with the Use of KillerRed

(2013) Daniel C. Williams et al.   Cell Reports

Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response

(2012) Ho Lam Tang et al.   MOLECULAR BIOLOGY OF THE CELL

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

Apoptotic regulation of epithelial cellular extrusion

(2011) Daniel Andrade et al.   APOPTOSIS

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway

(2011) Yapeng Gu et al.   JOURNAL OF CELL BIOLOGY

Engineering a Photoactivated Caspase-7 for Rapid Induction of Apoptosis

(2011) Evan Mills et al.   ACS Synthetic Biology

Optogenetic in vivo cell manipulation in KillerRed-expressing zebrafish transgenics

(2010) Cathleen Teh et al.   BMC DEVELOPMENTAL BIOLOGY

Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation

(2010) Andrew Oberst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses

(2008) Aisada Uchugonova et al.   Journal of Biophotonics

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY