Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

(2014) Claudia Günther et al.   GUT

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth

(2014) Changyou Li et al.   Molecular Oncology

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Assessment of Tumor Development and Wound Healing Using Endoscopic Techniques in Mice

(2010) Markus F. Neurath et al.   GASTROENTEROLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Caspase-8 in cancer biology and therapy

(2008) Simone Fulda   CANCER LETTERS