Targeted inhibition of MASTL kinase activity induces apoptosis in breast cancer

Therapeutic natural compounds Enzastaurin and Palbociclib inhibit MASTL kinase activity preventing breast cancer cell proliferation

(2022) Aneesha Polisety et al.   MEDICAL ONCOLOGY

DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)

(2022) Brad T Sherman et al.   NUCLEIC ACIDS RESEARCH

MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels

(2022) Elisa Närvä et al.   iScience

Knockdown of Microtubule Associated Serine/threonine Kinase Like Expression Inhibits Gastric Cancer Cell Growth and Induces Apoptosis by Activation of ERK1/2 and Inactivation of NF-κB Signaling

(2021) Cai-xia An et al.   Current Medical Science

Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

(2021) Minsung Kang et al.   Pharmaceuticals

Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer Pathogenesis

(2020) Sylwia Pietrasik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of CD44 sensitizes cisplatin-resistance and affects Wnt/β-catenin signaling in HNSCC cells

(2020) Souvick Roy et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

MASTL promotes cell contractility and motility through kinase-independent signaling

(2020) Maria Emilia Taskinen et al.   JOURNAL OF CELL BIOLOGY

MASTL: A novel therapeutic target for Cancer Malignancy

(2020) Iram Fatima et al.   Cancer Medicine

Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting

(2020) James Ronald William Conway et al.   Cells

The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis

(2020) Xavier Bisteau et al.   ONCOGENE

MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer

(2020) Ah-Young Kim et al.   Frontiers in Oncology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

OUP accepted manuscript

(2018)   BIOINFORMATICS

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

(2018) Yi Na Yoon et al.   BMC CANCER

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

(2018) Samuel Rogers et al.   ONCOGENE

GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway

(2018) Susann Kleinsimon et al.   Scientific Reports

Identification of new inhibitors against human Great wall kinase using in silico approaches

(2018) Ummi Ammarah et al.   Scientific Reports

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

(2018) Srijayaprakash Babu Uppada et al.   Molecular Cancer

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

(2018) Elena Cetti et al.   CANCER LETTERS

Vibrational and optical characterization of s-triazine derivatives

(2017) Luigi Stagi et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptor

(2017) Amit Kumar et al.   Scientific Reports

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

(2016) Cory A. Ocasio et al.   Oncotarget

MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation

(2016) Po Yee Wong et al.   Scientific Reports

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

Dynamical insights into the differential characteristics of Mycobacterium avium subsp. paratuberculosis peptide binding to HLA-DRB1 proteins associated with multiple sclerosis

(2015) Amit Kumar et al.   NEW JOURNAL OF CHEMISTRY

Antigenic peptide molecular recognition by the DRB1–DQB1 haplotype modulates multiple sclerosis susceptibility

(2014) Amit Kumar et al.   Molecular BioSystems

PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit

(2014) Nadia Hégarat et al.   PLoS Genetics

AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

(2013) José M. Arencibia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

GADD45 Proteins: Central Players in Tumorigenesis

(2012) R. E. Tamura et al.   CURRENT MOLECULAR MEDICINE

Nerve growth factor receptor (NGFR): a potential marker for specific molecular subtypes of breast cancer

(2012) Julia Y S Tsang et al.   JOURNAL OF CLINICAL PATHOLOGY

The Greatwall kinase: a new pathway in the control of the cell cycle

(2012) T Lorca et al.   ONCOGENE

Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor

(2012) Masatoshi Hara et al.   Nature Communications

Characterization of the Mechanisms Controlling Greatwall Activity

(2011) S. Vigneron et al.   MOLECULAR AND CELLULAR BIOLOGY

MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

(2010) Erik Voets et al.   CELL CYCLE

NWChem: A comprehensive and scalable open-source solution for large scale molecular simulations

(2010) M. Valiev et al.   COMPUTER PHYSICS COMMUNICATIONS

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS