Therapeutic natural compounds Enzastaurin and Palbociclib inhibit MASTL kinase activity preventing breast cancer cell proliferation

Knockdown of Microtubule Associated Serine/threonine Kinase Like Expression Inhibits Gastric Cancer Cell Growth and Induces Apoptosis by Activation of ERK1/2 and Inactivation of NF-κB Signaling

(2021) Cai-xia An et al.   Current Medical Science

Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression

(2021) Myreille Larouche et al.   JOURNAL OF CELL BIOLOGY

MASTL regulates EGFR signaling to impact pancreatic cancer progression

(2021) Iram Fatima et al.   ONCOGENE

Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2

(2021) Ahmed Kandeil et al.   Pathogens

Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

(2021) Minsung Kang et al.   Pharmaceuticals

MASTL promotes cell contractility and motility through kinase-independent signaling

(2020) Maria Emilia Taskinen et al.   JOURNAL OF CELL BIOLOGY

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Screening of Natural Stilbene Oligomers from Vitis vinifera for Anticancer Activity on Human Hepatocellular Carcinoma Cells

(2020) Iris Aja et al.   Antioxidants

MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer

(2020) Ah-Young Kim et al.   Frontiers in Oncology

Inflammatory cytokine‑induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression

(2019) Liye Cao et al.   Oncology Letters

Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors

(2018) Shenglin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

(2018) Yi Na Yoon et al.   BMC CANCER

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

(2018) Samuel Rogers et al.   ONCOGENE

Identification of new inhibitors against human Great wall kinase using in silico approaches

(2018) Ummi Ammarah et al.   Scientific Reports

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

(2018) Srijayaprakash Babu Uppada et al.   Molecular Cancer

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

(2018) Elena Cetti et al.   CANCER LETTERS

Salvianolic acid A, a novel PI3K/Akt inhibitor, induces cell apoptosis and suppresses tumor growth in acute myeloid leukemia

(2017) Renzhi Pei et al.   LEUKEMIA & LYMPHOMA

CoCl2 increases the expression of hypoxic markers HIF‑1α, VEGF and CXCR4 in breast cancer MCF‑7 cells

(2017) Qing Li et al.   Oncology Letters

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response

(2016) Tyzoon K. Nomanbhoy et al.   BIOCHEMISTRY

The master Greatwall kinase, a critical regulator of mitosis and meiosis

(2016) Suzanne Vigneron et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

(2016) Cory A. Ocasio et al.   Oncotarget

The contractome - a systems view of actomyosin contractility in non-muscle cells

(2015) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

(2015) Jorge Vera et al.   eLife

Mastl kinase, a promising therapeutic target, promotes cancer recurrence

(2015) Ling Wang et al.   Oncotarget

Characterization of the Mechanisms Controlling Greatwall Activity

(2011) S. Vigneron et al.   MOLECULAR AND CELLULAR BIOLOGY

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE