Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes

MASTL: A novel therapeutic target for Cancer Malignancy

(2020) Iram Fatima et al.   Cancer Medicine

The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis

(2020) Xavier Bisteau et al.   ONCOGENE

MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer

(2020) Ah-Young Kim et al.   Frontiers in Oncology

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

(2018) Yi Na Yoon et al.   BMC CANCER

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

(2018) Samuel Rogers et al.   ONCOGENE

Identification of new inhibitors against human Great wall kinase using in silico approaches

(2018) Ummi Ammarah et al.   Scientific Reports

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

(2018) Srijayaprakash Babu Uppada et al.   Molecular Cancer

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

(2018) Elena Cetti et al.   CANCER LETTERS

Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer

(2017) Xian‑Jun Sun et al.   Oncology Letters

Breast cancer stem cells in HER2-negative breast cancer cells contribute to HER2-mediated radioresistance and molecular subtype conversion: clinical implications for serum HER2 in recurrent HER2-negative breast cancer

(2017) Yun Gyoung Kim et al.   Oncotarget

PP2A as a master regulator of the cell cycle

(2016) Nathan Wlodarchak et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

(2016) Cory A. Ocasio et al.   Oncotarget

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening

(2015) Maria Chiara Anania et al.   Oncotarget

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

(2015) Jorge Vera et al.   eLife

Mastl kinase, a promising therapeutic target, promotes cancer recurrence

(2015) Ling Wang et al.   Oncotarget

Role of Greatwall kinase in release of mouse oocytes from diplotene arrest

(2014) Xiangyu Zhao et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

(2014) Deepak Adhikari et al.   JOURNAL OF CELL BIOLOGY

Greatwall Kinase Is Required for Meiotic Maturation in Porcine Oocytes1

(2013) Ying-Hua Li et al.   BIOLOGY OF REPRODUCTION

CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1

(2013) J.-S. Kim et al.   CANCER RESEARCH

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

(2013) M. Alvarez-Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

(2012) T. A. Yap et al.   CLINICAL CANCER RESEARCH

Regulation of Greatwall kinase during Xenopus oocyte maturation

(2011) Tomomi M. Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production

(2010) Jae-Sung Kim et al.   PROTEOMICS

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

Greatwall maintains mitosis through regulation of PP2A

(2009) Suzanne Vigneron et al.   EMBO JOURNAL

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY