Antigenic peptide molecular recognition by the DRB1–DQB1 haplotype modulates multiple sclerosis susceptibility

Structural and Dynamical Insights on HLA-DR2 Complexes That Confer Susceptibility to Multiple Sclerosis in Sardinia: A Molecular Dynamics Simulation Study

(2013) Amit Kumar et al.   PLoS One

Interaction between HLA-DRB1-DQB1 Haplotypes in Sardinian Multiple Sclerosis Population

(2013) Eleonora Cocco et al.   PLoS One

On the Importance and Origin of Aromatic Interactions in Chemistry and Biodisciplines

(2012) Kevin E. Riley et al.   ACCOUNTS OF CHEMICAL RESEARCH

For many but not for all: how the conformational flexibility of the peptide/MHCII complex shapes epitope selection

(2012) Andrea Ferrante   IMMUNOLOGIC RESEARCH

Enthalpy–Entropy Compensation and Cooperativity as Thermodynamic Epiphenomena of Structural Flexibility in Ligand–Receptor Interactions

(2012) Andrea Ferrante et al.   JOURNAL OF MOLECULAR BIOLOGY

DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)

(2012) Nathali Kaushansky et al.   Journal of Neuroinflammation

HLA-DRB1-DQB1 Haplotypes Confer Susceptibility and Resistance to Multiple Sclerosis in Sardinia

(2012) Eleonora Cocco et al.   PLoS One

Aromatic interaction profile to understand the molecular basis of raltegravir resistance

(2012) Tuniki Balaraju et al.   STRUCTURAL CHEMISTRY

Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers

(2012) Christopher J. Holland et al.   Scientific Reports

Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a pMHC-TCR Complex

(2012) Cyril F. Reboul et al.   PLoS Computational Biology

Revealing the genetic basis of multiple sclerosis: are we there yet?

(2011) Sergio E Baranzini   CURRENT OPINION IN GENETICS & DEVELOPMENT

Environmental triggers of multiple sclerosis

(2011) Kristina Kakalacheva et al.   FEBS LETTERS

Epstein-Barr virus and multiple sclerosis: interaction with HLA

(2011) E Sundqvist et al.   GENES AND IMMUNITY

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease

(2011) Emily M. L. Chastain et al.   IMMUNOLOGICAL REVIEWS

Disparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding Mechanism

(2011) Daniel R. Scott et al.   JOURNAL OF MOLECULAR BIOLOGY

Small molecule modulators of MHC class II antigen presentation: Mechanistic insights and implications for therapeutic application

(2011) Melissa J. Call   MOLECULAR IMMUNOLOGY

Epstein–Barr virus nuclear antigen-1 B-cell epitopes in multiple sclerosis twins

(2011) R Mechelli et al.   Multiple Sclerosis Journal

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Characterization of Structural Features Controlling the Receptiveness of Empty Class II MHC Molecules

(2011) Bernd Rupp et al.   PLoS One

Central nervous system myelin: structure, synthesis and assembly

(2011) Shweta Aggarwal et al.   TRENDS IN CELL BIOLOGY

Eucb: A C++ program for molecular dynamics trajectory analysis

(2010) Ioannis G. Tsoulos et al.   COMPUTER PHYSICS COMMUNICATIONS

Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

(2010) Scheherazade Sadegh-Nasseri et al.   IMMUNOLOGIC RESEARCH

Molecular and structural determinants of adamantyl susceptibility to HLA-DRs allelic variants: an in silico approach to understand the mechanism of MLEs

(2010) Zaheer-ul-Haq et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IEDB-3D: structural data within the immune epitope database

(2010) J. Ponomarenko et al.   NUCLEIC ACIDS RESEARCH

A Comparative Approach Linking Molecular Dynamics of Altered Peptide Ligands and MHC with In Vivo Immune Responses

(2010) Bernhard Knapp et al.   PLoS One

Bidirectional binding of invariant chain peptides to an MHC class II molecule

(2010) S. Gunther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

(2010) Peter Csermely et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural Biology of the T-cell Receptor: Insights into Receptor Assembly, Ligand Recognition, and Initiation of Signaling

(2010) K. W. Wucherpfennig et al.   Cold Spring Harbor Perspectives in Biology

The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis

(2009) Nathali Kaushansky et al.   AUTOIMMUNITY REVIEWS

Structural Polymorphism and Multifunctionality of Myelin Basic Protein

(2009) George Harauz et al.   BIOCHEMISTRY

Multiple sclerosis and the major histocompatibility complex

(2009) Sreeram V Ramagopalan et al.   CURRENT OPINION IN NEUROLOGY

T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides

(2009) Maria Harkiolaki et al.   IMMUNITY

HLA-DQB1*0602 Determines Disease Susceptibility in a New "Humanized" Multiple Sclerosis Model in HLA-DR15 (DRB1*1501;DQB1*0602) Transgenic Mice

(2009) N. Kaushansky et al.   JOURNAL OF IMMUNOLOGY

Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: A molecular dynamics simulation study

(2008) Rakina Yaneva et al.   BIOPOLYMERS

Molecular Dynamics—Solvated Interaction Energy Studies of Protein–Protein Interactions: The MP1–p14 Scaffolding Complex

(2008) Qizhi Cui et al.   JOURNAL OF MOLECULAR BIOLOGY

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

(2008) Jorge R. Oksenberg et al.   NATURE REVIEWS GENETICS

A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach

(2008) Peng Wang et al.   PLoS Computational Biology