MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

(2018) Yi Na Yoon et al.   BMC CANCER

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

(2018) Samuel Rogers et al.   ONCOGENE

Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression

(2018) Lingdi Zhang et al.   Nature Communications

Identification of new inhibitors against human Great wall kinase using in silico approaches

(2018) Ummi Ammarah et al.   Scientific Reports

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

(2018) Srijayaprakash Babu Uppada et al.   Molecular Cancer

Mitosis perturbation by MASTL depletion impairs the viability of thyroid tumor cells

(2018) Elena Cetti et al.   CANCER LETTERS

Breast cancer stem cells in HER2-negative breast cancer cells contribute to HER2-mediated radioresistance and molecular subtype conversion: clinical implications for serum HER2 in recurrent HER2-negative breast cancer

(2017) Yun Gyoung Kim et al.   Oncotarget

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

(2016) Cory A. Ocasio et al.   Oncotarget

MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation

(2016) Po Yee Wong et al.   Scientific Reports

Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC

(2015) R. Nagel et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening

(2015) Maria Chiara Anania et al.   Oncotarget

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

(2015) Jorge Vera et al.   eLife

Mastl kinase, a promising therapeutic target, promotes cancer recurrence

(2015) Ling Wang et al.   Oncotarget

Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

(2014) Evanthia Lionta et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Role of Greatwall kinase in release of mouse oocytes from diplotene arrest

(2014) Xiangyu Zhao et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Greatwall Kinase Is Required for Meiotic Maturation in Porcine Oocytes1

(2013) Ying-Hua Li et al.   BIOLOGY OF REPRODUCTION

CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1

(2013) J.-S. Kim et al.   CANCER RESEARCH

Docking Challenge: Protein Sampling and Molecular Docking Performance

(2013) Khaled M. Elokely et al.   Journal of Chemical Information and Modeling

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity

(2012) Appalaraju Jaggupilli et al.   Clinical & Developmental Immunology

AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

(2012) T. A. Yap et al.   CLINICAL CANCER RESEARCH

Bypassing the Greatwall-Endosulfine Pathway: Plasticity of a Pivotal Cell-Cycle Regulatory Module in Drosophila melanogaster and Caenorhabditis elegans

(2012) M.-Y. Kim et al.   GENETICS

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

Greatwall and Polo-like Kinase 1 Coordinate to Promote Checkpoint Recovery

(2011) Aimin Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Greatwall kinase during Xenopus oocyte maturation

(2011) Tomomi M. Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel role for Greatwall kinase in recovery from DNA damage

(2010) Aimin Peng et al.   CELL CYCLE

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production

(2010) Jae-Sung Kim et al.   PROTEOMICS

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

Greatwall maintains mitosis through regulation of PP2A

(2009) Suzanne Vigneron et al.   EMBO JOURNAL

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiple pathways regulated by the tumor suppressor PP2A in transformation

(2008) Jukka Westermarck et al.   TRENDS IN MOLECULAR MEDICINE