Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting

MASTL promotes cell contractility and motility through kinase-independent signaling

(2020) Maria Emilia Taskinen et al.   JOURNAL OF CELL BIOLOGY

An open-source drug discovery platform enables ultra-large virtual screens

(2020) Christoph Gorgulla et al.   NATURE

ENSA and ARPP19 differentially control cell cycle progression and development

(2019) Khaled Hached et al.   JOURNAL OF CELL BIOLOGY

Dephosphorylation of Plk1 occurs through PP2A-B55/ENSA/Greatwall pathway during mitotic DNA damage recovery

(2019) Shin-Young Kim et al.   CELL CYCLE

Molecular Basis of the Mechanisms Controlling MASTL

(2019) Dario Hermida et al.   MOLECULAR & CELLULAR PROTEOMICS

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

(2018) Samuel Rogers et al.   ONCOGENE

Identification of new inhibitors against human Great wall kinase using in silico approaches

(2018) Ummi Ammarah et al.   Scientific Reports

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

(2018) Srijayaprakash Babu Uppada et al.   Molecular Cancer

Greatwall kinase at a glance

(2018) Anna Castro et al.   JOURNAL OF CELL SCIENCE

Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets

(2018) Begoña Hurtado et al.   JOURNAL OF CLINICAL INVESTIGATION

Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma

(2018) Otília Menyhárt et al.   Royal Society Open Science

The human protein atlas: A spatial map of the human proteome

(2017) Peter J. Thul et al.   PROTEIN SCIENCE

Cellular Reorganization during Mitotic Entry

(2017) Lysie Champion et al.   TRENDS IN CELL BIOLOGY

β-Catenin promotes cell proliferation, migration, and invasion but induces apoptosis in renal cell carcinoma

(2017) Chun-Ming Yang et al.   OncoTargets and Therapy

Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer

(2017) Xian‑Jun Sun et al.   Oncology Letters

Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma

(2016) Meike Dahlhaus et al.   CANCER LETTERS

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

(2016) Cory A. Ocasio et al.   Oncotarget

Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement

(2015) Subramanian P. Ramanathan et al.   NATURE CELL BIOLOGY

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

(2015) Jorge Vera et al.   eLife

Mastl kinase, a promising therapeutic target, promotes cancer recurrence

(2015) Ling Wang et al.   Oncotarget

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

(2014) Byron C Williams et al.   eLife

Myocardin related transcription factors are required for coordinated cell cycle progression

(2013) Dmitry Shaposhnikov et al.   CELL CYCLE

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

PKB/Akt-Dependent Regulation of Cell Motility

(2013) G. Xue et al.   JNCI-Journal of the National Cancer Institute

miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase

(2013) Kun Wang et al.   NEURO-ONCOLOGY

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

(2013) M. Alvarez-Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton

(2012) Donald L. Ly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

(2012) Balázs Győrffy et al.   ENDOCRINE-RELATED CANCER

Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry

(2012) K. A. Blake-Hodek et al.   MOLECULAR AND CELLULAR BIOLOGY

The secret life of kinases: functions beyond catalysis

(2011) Jens Rauch et al.   Cell Communication and Signaling

Monoclonal Antibodies Against Xenopus Greatwall Kinase

(2011) Ling Wang et al.   HYBRIDOMA

MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

(2010) Erik Voets et al.   CELL CYCLE

Actin cytoskeleton dynamics and the cell division cycle

(2010) Yi-Wen Heng et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

In vivo inactivation of MASTL kinase results in thrombocytopenia

(2009) H. Jan Johnson et al.   EXPERIMENTAL HEMATOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The actin cytoskeleton in spindle assembly and positioning

(2009) Patricia Kunda et al.   TRENDS IN CELL BIOLOGY

Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

(2008) Jörg Birkenfeld et al.   TRENDS IN CELL BIOLOGY