Melatonin prevents EAAC1 deletion‐induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence

AAV‐mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice

(2022) J. Roig‐Soriano et al.   AGING CELL

EphA4 / ephrinA3 reverse signaling mediated downregulation of glutamate transporter GLAST in Müller cells in an experimental glaucoma model

(2022) Zhi‐Xin Zhou et al.   GLIA

CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson disease

(2021) Gregory P Williams et al.   BRAIN

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

(2021) Anthony Lagnado et al.   EMBO JOURNAL

Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma

(2021) Denis Gubin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Prevents Non-image-Forming Visual System Alterations Induced by Experimental Glaucoma in Rats

(2021) María F. González Fleitas et al.   MOLECULAR NEUROBIOLOGY

Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts

(2021) Hua-Long Zhu et al.   Redox Biology

Mitochondrial dysfunction triggers the pathogenesis of Parkinson’s disease in neuronal C/EBPβ transgenic mice

(2021) Eun Hee Ahn et al.   MOLECULAR PSYCHIATRY

Retinal oxidative stress activates the NRF2/ARE pathway: An early endogenous protective response to ocular hypertension

(2021) Sarah Naguib et al.   Redox Biology

Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy

(2021) Jeremy A. Hansell et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease

(2021) Chongyang Chen et al.   JOURNAL OF PINEAL RESEARCH

LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity

(2021) Pengyi Yan et al.   Cell Reports

Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer’s Disease

(2020) Zhongli Shi et al.   AGING CELL

Melatonin suppresses senescence‐derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L–mitophagy pathway

(2020) Jun Hee Lee et al.   AGING CELL

The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models

(2020) Makoto Ishikawa et al.   Autophagy

Adreno–melatonin receptor complexes control ion homeostasis and intraocular pressure ‐ their disruption contributes to hypertensive glaucoma

(2020) Hanan Awad Alkozi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

(2020) Wei Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cypermethrin-induced cortical neurons apoptosis via the Nrf2/ARE signaling pathway

(2020) Lihua Zhou et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration

(2020) Soo-Ho Choi et al.   Redox Biology

Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation

(2020) Rasmus Berglund et al.   Science Immunology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma

(2019) Hiroki Sano et al.   Cell Death & Disease

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

(2019) Mario Merlini et al.   NEURON

Blockade of microglial adenosine A 2A receptor suppresses elevated pressure‐induced inflammation, oxidative stress, and cell death in retinal cells

(2019) Inês Dinis Aires et al.   GLIA

XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence

(2019) Shuai Hou et al.   NUCLEIC ACIDS RESEARCH

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

(2019) Ziwen Wang et al.   Nature Communications

Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer

(2019) Ruth E. Musgrove et al.   JOURNAL OF CLINICAL INVESTIGATION

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

7T MRI Predicts Amelioration of Neurodegeneration in the Brain after AAV Gene Therapy

(2019) Heather L. Gray-Edwards et al.   Molecular Therapy-Methods & Clinical Development

Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo

(2018) Elena Kozina et al.   BRAIN

ISCEV guide to visual electrodiagnostic procedures

(2018) Anthony G. Robson et al.   DOCUMENTA OPHTHALMOLOGICA

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

(2018) Yuanyuan Chen et al.   Nature Communications

Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer

(2018) Hui Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Soluble receptor for advance glycation end-products inhibits ischemia/reperfusion-induced myocardial autophagy via the STAT3 pathway

(2018) Mengqiu Dang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglia mediate non-cell-autonomous cell death of retinal ganglion cells

(2018) Akiko Takeda et al.   GLIA

Intraocular pressure–independent management of normal tension glaucoma

(2018) Jennifer Adeghate et al.   SURVEY OF OPHTHALMOLOGY

Managing normal tension glaucoma by lowering the intraocular pressure

(2018) M. Reza Razeghinejad et al.   SURVEY OF OPHTHALMOLOGY

Genetics of glaucoma

(2017) Janey L. Wiggs et al.   HUMAN MOLECULAR GENETICS

Glaucoma

(2017) Jost B Jonas et al.   LANCET

Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma

(2017) Kei Akaiwa et al.   Cell Death & Disease

Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes

(2017) Wucai Yang et al.   Scientific Reports

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

FOXO1 is a TXN- and p300-dependent sensor and effector of oxidative stress in diffuse large B-cell lymphomas characterized by increased oxidative metabolism

(2016) T Sewastianik et al.   ONCOGENE

A novel human model of the neurodegenerative disease GM1 gangliosidosis using induced pluripotent stem cells demonstrates inflammasome activation

(2015) Mi-Young Son et al.   JOURNAL OF PATHOLOGY

NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress

(2015) Po-Jen Chen et al.   NUCLEIC ACIDS RESEARCH

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Population-based glaucoma prevalence studies in Asians

(2014) Hyun-kyung Cho et al.   SURVEY OF OPHTHALMOLOGY

Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1)

(2013) Koji Aoyama et al.   AMINO ACIDS

Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma

(2013) K Namekata et al.   CELL DEATH AND DIFFERENTIATION

Melatonin: a novel neuroprotectant for the treatment of glaucoma

(2010) Nicolás A. Belforte et al.   JOURNAL OF PINEAL RESEARCH