The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABAA receptors in rat glaucoma models

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

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Astrocyte Autophagy Flux Protects Neurons Against Oxygen-Glucose Deprivation and Ischemic/Reperfusion Injury

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(2016) Benjamin Michael Davis et al.   ACTA NEUROPATHOLOGICA

TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model

(2016) Makoto Ishikawa et al.   NEUROPHARMACOLOGY

Autophagy in glaucoma: Crosstalk with apoptosis and its implications

(2015) Yao Wang et al.   BRAIN RESEARCH BULLETIN

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(2015) Junya Hasegawa et al.   METHODS

Autophagy in axonal degeneration in glaucomatous optic neuropathy

(2015) Yasunari Munemasa et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model

(2014) M. Ishikawa et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Rapamycin Is Neuroprotective in a Rat Chronic Hypertensive Glaucoma Model

(2014) Wenru Su et al.   PLoS One

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

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Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity

(2013) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2013) Y Kitaoka et al.   Cell Death & Disease

The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes

(2012) Bradlee L Heckmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

(2012) H-Y Lopilly Park et al.   Cell Death & Disease

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(2011) Terje Johansen et al.   Autophagy

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

The neurosteroids, allopregnanolone and progesterone, induce autophagy in cultured astrocytes

(2011) Ha Na Kim et al.   NEUROCHEMISTRY INTERNATIONAL

Targeting autophagy during cancer therapy to improve clinical outcomes

(2011) Jean M. Mulcahy Levy et al.   PHARMACOLOGY & THERAPEUTICS

Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

(2009) Paloma B. Liton et al.   Autophagy

Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates

(2009) Sovan Sarkar et al.   Autophagy

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(2009) Carson C. Thoreen et al.   Autophagy

Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1−/− mouse brain

(2009) Guanghong Liao et al.   BRAIN RESEARCH

Direct inhibition of the mitochondrial permeability transition pore: A possible mechanism for better neuroprotective effects of allopregnanolone over progesterone

(2009) Iqbal Sayeed et al.   BRAIN RESEARCH

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION