Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy

(2018) Pooja Singhmar et al.   PAIN

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development

(2018) William G. Robichaux et al.   PHYSIOLOGICAL REVIEWS

Epac1 protects the retina against ischemia/reperfusion-induced neuronal and vascular damage

(2018) Li Liu et al.   PLoS One

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

(2018) Huihui Chen et al.   Nature Communications

Epac1−/− mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights

(2018) Fitz-Roy E. Curry et al.   Acta Physiologica

Reduced Annexin A1 Secretion by ABCA1 Causes Retinal Inflammation and Ganglion Cell Apoptosis in a Murine Glaucoma Model

(2018) Lu Li et al.   Frontiers in Cellular Neuroscience

A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model

(2017) Yun-Ju Do et al.   EXPERIMENTAL CELL RESEARCH

Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

(2017) Haiying Zhang et al.   Journal of Neuroinflammation

Increased microvascular permeability in mice lacking Epac1 (Rapgef3)

(2016) R. K. Kopperud et al.   Acta Physiologica

Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness

(2016) Jonathan Scott et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

(2016) Pooja Singhmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

(2016) Maria H. Madeira et al.   Translational Research

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

(2016) Esraa Shosha et al.   Cell Death & Disease

A Mouse Model of Retinal Ischemia-Reperfusion Injury Through Elevation of Intraocular Pressure

(2016) Matthew J. Hartsock et al.   Jove-Journal of Visualized Experiments

Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury

(2015) Ruiqi Cai et al.   FASEB JOURNAL

Structure–Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N′-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists

(2015) Na Ye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

(2015) Maria H. Madeira et al.   Journal of Neuroinflammation

Curcumin Inhibits Neuronal Loss in the Retina and Elevates Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Rats

(2015) Jun Li et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma

(2015) Dorota Skowronska-Krawczyk et al.   MOLECULAR CELL

Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes

(2015) Laëtitia Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

(2015) Y Ha et al.   Cell Death & Disease

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

(2015) Marko Kostic et al.   Cell Reports

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

(2015) Yingmin Zhu et al.   Scientific Reports

The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

(2014) Flavia D. Toledo et al.   ARCHIVES OF TOXICOLOGY

Gastrodin Inhibits Glutamate-Induced Apoptosis of PC12 Cells via Inhibition of CaMKII/ASK-1/p38 MAPK/p53 Signaling Cascade

(2014) Genling Jiang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia–reperfusion-induced retinal damage

(2014) Galina Dvoriantchikova et al.   EXPERIMENTAL EYE RESEARCH

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses

(2014) Satoshi Okumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β2-adrenoceptor stimulation

(2014) Yoshiki Ohnuki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKA: Lessons learned after twenty years

(2013) Susan S. Taylor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

(2013) Huijing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC)

(2013) Haijun Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Opposing HDAC4 nuclear fluxes due to phosphorylation by β-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres

(2013) Yewei Liu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Therapeutic Effects of PPARα Agonists on Diabetic Retinopathy in Type 1 Diabetes Models

(2012) Ying Chen et al.   DIABETES

The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma

(2012) Frances E. Cone et al.   EXPERIMENTAL EYE RESEARCH

Social, Communication, and Cortical Structural Impairments in Epac2-Deficient Mice

(2012) D. P. Srivastava et al.   JOURNAL OF NEUROSCIENCE

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

(2012) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

(2012) Ying Yang et al.   NEURON

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

CaMKII regulates pericyte loss in the retina of early diabetic mouse

(2011) Young Hee Kim et al.   MOLECULES AND CELLS

Resveratrol Inhibits Neuronal Apoptosis and Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Mouse Retina

(2010) Y.-H. Kim et al.   DIABETES

Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection

(2010) Frances E. Cone et al.   EXPERIMENTAL EYE RESEARCH

Differential Roles of Epac in Regulating Cell Death in Neuronal and Myocardial Cells

(2010) Sayaka Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation

(2010) Supachoke Mangmool et al.   JOURNAL OF CELL BIOLOGY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential distribution of exchange proteins directly activated by cyclic AMP within the adult rat retina

(2009) C.M. Whitaker et al.   NEUROSCIENCE

The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

(2009) C.-L. Zhang et al.   SCIENCE

Epac and PKA: a tale of two intracellular cAMP receptors

(2008) Xiaodong Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Selective blockade of CaMKII-α inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons

(2008) Dennis J. Goebel   BRAIN RESEARCH

8-pCPT-2′-O-Me-cAMP-AM: An Improved Epac-Selective cAMP Analogue

(2008) Marjolein J. Vliem et al.   CHEMBIOCHEM

Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy

(2008) Mélanie Métrich et al.   CIRCULATION RESEARCH

5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

(2008) R. A. Gubitosi-Klug et al.   DIABETES

Epac and Phospholipase Cϵ Regulate Ca2+Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

(2008) Emily A. Oestreich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY