Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

(2018) Brian O. Diekman et al.   AGING CELL

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Cellular senescence impact on immune cell fate and function

(2016) Rita Vicente et al.   AGING CELL

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

M2 polarization of murine peritoneal macrophages induces regulatory cytokine production and suppresses T-cell proliferation

(2016) Shinji Oishi et al.   IMMUNOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

(2015) Kristen Fortney et al.   PLoS Genetics

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

(2014) Benjamin D Cosgrove et al.   NATURE MEDICINE

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

(2013) Darren J. Baker et al.   Cell Reports

Review: a meta-analysis of GWAS and age-associated diseases

(2012) William R. Jeck et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a

(2012) B. Berent-Maoz et al.   BLOOD

Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals

(2012) H. Tani et al.   GENOME RESEARCH

Classical Macrophage Activation Up-Regulates Several Matrix Metalloproteinases through Mitogen Activated Protein Kinases and Nuclear Factor-κB

(2012) Wei-Chun Huang et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

(2011) Chao-Ling Kuo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of p16INK4a prevents cancer and promotes aging in lymphocytes

(2011) Y. Liu et al.   BLOOD

p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages

(2011) C. Cudejko et al.   BLOOD

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Real-time in vivo imaging of p16Ink4a gene expression: a new approach to study senescence stress signaling in living animals

(2010) Naoko Ohtani et al.   Cell Division

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Age-Dependent Decline in  -Cell Proliferation Restricts the Capacity of  -Cell Regeneration in Mice

(2009) S.-I. Tschen et al.   DIABETES

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

(2009) Yan Liu et al.   PLoS One

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY