CD28/PD1 co-expression: dual impact on CD8+ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response

cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity

(2023) Yunlong Zhao et al.   IMMUNITY

Functional Engagement of the PD-1/PD-L1 Complex But Not PD-L1 Expression Is Highly Predictive of Patient Response to Immunotherapy in Non–Small-Cell Lung Cancer

(2023) Lissete Sánchez-Magraner et al.   JOURNAL OF CLINICAL ONCOLOGY

CTLA4 prohibits T cells from cross-dressing

(2023) Noémie Paillon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An integrated single-cell transcriptomic dataset for non-small cell lung cancer

(2023) Karolina Hanna Prazanowska et al.   Scientific Data

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses

(2022) Karl L. Banta et al.   IMMUNITY

Heterogeneity of tissue resident memory T cells

(2022) Špela Konjar et al.   IMMUNOLOGY LETTERS

‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses

(2022) Dietmar Zehn et al.   NATURE IMMUNOLOGY

Regulatory T‐cell development in the tumor microenvironment

(2022) Kota Itahashi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer

(2021) Moran Yang et al.   Journal for ImmunoTherapy of Cancer

Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells

(2021) Liliana E. Lucca et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8+ regulatory T cells

(2021) Alejandro J. Cagnoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

(2021) Romain Banchereau et al.   Journal for ImmunoTherapy of Cancer

CD27 expression on Treg cells limits immune responses against tumors

(2021) Sabine Muth et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

(2021) Susan N. Christo et al.   NATURE IMMUNOLOGY

Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment

(2021) Yuechen Luo et al.   Nature Communications

Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small-cell lung cancer

(2021) L. Federico et al.   ANNALS OF ONCOLOGY

Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

(2021) Jaikumar Duraiswamy et al.   CANCER CELL

Single-cell profiling reveals the importance of CXCL13/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma

(2021) Tomohiro Aoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target

(2020) Zachary T. Freeman et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripheral T cell expansion predicts tumour infiltration and clinical response

(2020) Thomas D. Wu et al.   NATURE

The nf-core framework for community-curated bioinformatics pipelines

(2020) Philip A. Ewels et al.   NATURE BIOTECHNOLOGY

Frontline immunotherapy for NSCLC — the tale of the tail

(2020) Anne C. Chiang et al.   Nature Reviews Clinical Oncology

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

(2020) Hanjie Li et al.   CELL

PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15

(2020) Kyung Hwan Kim et al.   Cellular & Molecular Immunology

Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

(2020) J. Justin Milner et al.   IMMUNITY

IRF4 instructs effector Treg differentiation and immune suppression in human cancer

(2020) Giorgia Alvisi et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

(2020) Camille-Charlotte Balança et al.   Cancer Immunology Research

Early precursors and molecular determinants of tissue-resident memory CD8+ T lymphocytes revealed by single-cell RNA sequencing

(2020) Nadia S. Kurd et al.   Science Immunology

KLRG1+ Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory

(2020) Kristin R. Renkema et al.   JOURNAL OF IMMUNOLOGY

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

(2020) Giovanni Galletti et al.   NATURE IMMUNOLOGY

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

(2020) Yunfan Sun et al.   CELL

A transcriptionally distinct CXCL13+CD103+CD8+ T-cell population is associated with B-cell recruitment and neoantigen load in human cancer

(2019) Hagma H Workel et al.   Cancer Immunology Research

Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer

(2019) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

(2019) Yunlong Zhao et al.   IMMUNITY

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

KLRG1 + Effector CD8 + T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

(2018) Dietmar Herndler-Brandstetter et al.   IMMUNITY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients

(2018) Belinda Palermo et al.   OncoImmunology

Resident memory T cells, critical components in tumor immunology

(2018) Fathia Mami-Chouaib et al.   Journal for ImmunoTherapy of Cancer

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

CD11a and CD49d enhance the detection of antigen-specific T cells following human vaccination

(2017) Allison F. Christiaansen et al.   VACCINE

Local Inflammatory Cues Regulate Differentiation and Persistence of CD8 + Tissue-Resident Memory T Cells

(2017) Tessa Bergsbaken et al.   Cell Reports

Trends and advances in tumor immunology and lung cancer immunotherapy

(2016) Mohanad Aldarouish et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Polyfunctional Melan-A-specific tumor-reactive CD8+T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS

(2016) Ornella Franzese et al.   OncoImmunology

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

Dacarbazine Treatment before Peptide Vaccination Enlarges T-Cell Repertoire Diversity of Melan-A-Specific, Tumor-Reactive CTL in Melanoma Patients

(2010) B. Palermo et al.   CANCER RESEARCH

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD