Polyfunctional Melan-A-specific tumor-reactive CD8+T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS

Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8+T-cell proliferation and survival

(2015) Rasha Abu Eid et al.   OncoImmunology

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

(2014) A. B. van der Waart et al.   BLOOD

Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics

(2014) J. G. Crompton et al.   CANCER RESEARCH

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

(2014) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy

(2014) Xiaozhou Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Predicting the Impact of CD8+ T Cell Polyfunctionality on HIV Disease Progression

(2014) F. Graw et al.   JOURNAL OF VIROLOGY

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Sprouty-2 regulates HIV-specific T cell polyfunctionality

(2013) Yen-Ling Chiu et al.   JOURNAL OF CLINICAL INVESTIGATION

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

ICOS Regulates the Generation and Function of Human CD4+ Treg in a CTLA-4 Dependent Manner

(2013) Jian Zheng et al.   PLoS One

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

(2013) Amandine Legat et al.   Frontiers in Immunology

Polyfunctional CD4+ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy

(2012) Z.-C. Ding et al.   BLOOD

Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation

(2012) E. H. Kim et al.   JOURNAL OF IMMUNOLOGY

Interferon-α as Antiviral and Antitumor Vaccine Adjuvants: Mechanisms of Action and Response Signature

(2012) Eleonora Aricò et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Extended Co-Expression of Inhibitory Receptors by Human CD8 T-Cells Depending on Differentiation, Antigen-Specificity and Anatomical Localization

(2012) Lukas Baitsch et al.   PLoS One

Targeting PD-1/PD-L1 interactions for cancer immunotherapy

(2012) Laurence Zitvogel et al.   OncoImmunology

Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose

(2011) Tanja Lövgren et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

(2011) Andrew N. Macintyre et al.   IMMUNITY

Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade

(2011) Sian M. Henson et al.   IMMUNOLOGY

Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation

(2011) L. Janbazian et al.   JOURNAL OF IMMUNOLOGY

Phenotype, Function, and Gene Expression Profiles of Programmed Death-1 hi CD8 T Cells in Healthy Human Adults

(2011) Jaikumar Duraiswamy et al.   JOURNAL OF IMMUNOLOGY

Dacarbazine Treatment before Peptide Vaccination Enlarges T-Cell Repertoire Diversity of Melan-A-Specific, Tumor-Reactive CTL in Melanoma Patients

(2010) B. Palermo et al.   CANCER RESEARCH

Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells

(2010) N. Martin-Orozco et al.   CANCER RESEARCH

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of CD27/CD70 pathway of activation in immunity and tolerance

(2010) Julie Denoeud et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monitoring of NY-ESO-1 specific CD4+ T cells using molecularly defined MHC class II/His-tag-peptide tetramers

(2010) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD

Inducible Costimulator (ICOS) Enhances the Cytolytic Activity of Cytokine-Induced Killer Cells Against Gallbladder CancerIn VitroandIn Vivo

(2009) Jian Wang et al.   CANCER INVESTIGATION

Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients

(2009) N. Takahashi et al.   JOURNAL OF IMMUNOLOGY

Chemotherapy enhances vaccine-induced antitumor immunity in melanoma patients

(2008) Paola Nisticò et al.   INTERNATIONAL JOURNAL OF CANCER

Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells

(2008) G. Badr et al.   JOURNAL OF VIROLOGY

AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition

(2008) S. Caporali et al.   MOLECULAR PHARMACOLOGY

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

(2008) J. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA