Resident memory T cells, critical components in tumor immunology

CD103+Tumor-Resident CD8+T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment

(2018) Jarem Edwards et al.   CLINICAL CANCER RESEARCH

Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection

(2018) Thomas J. Connors et al.   JOURNAL OF IMMUNOLOGY

Trials and Tribble-ations of tissue TRM cells

(2018) Jun Siong Low et al.   NATURE IMMUNOLOGY

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

(2018) Simone L. Park et al.   NATURE IMMUNOLOGY

Tissue-resident memory T cells at the center of immunity to solid tumors

(2018) Derk Amsen et al.   NATURE IMMUNOLOGY

Reduced generation of lung tissue–resident memory T cells during infancy

(2017) Kyra D. Zens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

(2017) Michel Enamorado et al.   Nature Communications

Induction of resident memory T cells enhances the efficacy of cancer vaccine

(2017) Mevyn Nizard et al.   Nature Communications

Tissue-resident memory T cells play a key role in the efficacy of cancer vaccines

(2017) C. Granier et al.   OncoImmunology

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

(2017) Fenne L. Komdeur et al.   OncoImmunology

TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment

(2016) Marie Boutet et al.   CANCER RESEARCH

Tim-3 Expression on Tumor-Infiltrating PD-1 + CD8 + T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma

(2016) Clémence Granier et al.   CANCER RESEARCH

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

(2016) Saïda Dadi et al.   CELL

CD103 and Intratumoral Immune Response in Breast Cancer

(2016) Z.-Q. Wang et al.   CLINICAL CANCER RESEARCH

CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma

(2016) Hagma H. Workel et al.   EUROPEAN JOURNAL OF CANCER

Optimal Generation of Tissue-Resident but Not Circulating Memory T Cells during Viral Infection Requires Crosspriming by DNGR-1 + Dendritic Cells

(2016) Salvador Iborra et al.   IMMUNITY

Specific niches for lung-resident memory CD8 + T cells at the site of tissue regeneration enable CD69-independent maintenance

(2016) Shiki Takamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15–Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells

(2016) Jason M. Schenkel et al.   JOURNAL OF IMMUNOLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

(2016) L. K. Mackay et al.   SCIENCE

Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours

(2016) Lukasz Bialkowski et al.   Scientific Reports

Very Late Antigen-1 Marks Functional Tumor-Resident CD8 T Cells and Correlates with Survival of Melanoma Patients

(2016) Timothy Murray et al.   Frontiers in Immunology

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

Resident Memory T Cells as Surrogate Markers of the Efficacy of Cancer Vaccines

(2015) M. Nizard et al.   CLINICAL CANCER RESEARCH

Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract

(2015) Y.-Y. Sun et al.   CLINICAL CANCER RESEARCH

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

CD103+ Tumor Infiltrating Lymphocytes Predict a Favorable Prognosis in Urothelial Cell Carcinoma of the Bladder

(2015) Bo Wang et al.   JOURNAL OF UROLOGY

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

(2015) L M Wakim et al.   Mucosal Immunology

Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection

(2015) Tessa Bergsbaken et al.   NATURE IMMUNOLOGY

Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells

(2015) Rei Watanabe et al.   Science Translational Medicine

Tissue instruction for migration and retention of TRM cells

(2015) Norifumi Iijima et al.   TRENDS IN IMMUNOLOGY

A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control

(2015) Gang Xin et al.   Cell Reports

PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer

(2015) J. R. Webb et al.   Cancer Immunology Research

Intrinsically de-sialylated CD103+ CD8 T cells mediate beneficial anti-glioma immune responses

(2014) Emmanuel Jouanneau et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Smad and NFAT Pathways Cooperate To Induce CD103 Expression in Human CD8 T Lymphocytes

(2014) M. Mokrani et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Generation of Effector Cells That Localize to Mucosal Tissues and Form Resident Memory CD8 T Cells Is Controlled by mTOR

(2014) Ryan T. Sowell et al.   JOURNAL OF IMMUNOLOGY

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

(2014) Makoto Kurachi et al.   NATURE IMMUNOLOGY

Tumor-Infiltrating Lymphocytes Expressing the Tissue Resident Memory Marker CD103 Are Associated with Increased Survival in High-Grade Serous Ovarian Cancer

(2013) J. R. Webb et al.   CLINICAL CANCER RESEARCH

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid

(2013) Chuanwu Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

(2013) Cara N Skon et al.   NATURE IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

(2013) F. Sandoval et al.   Science Translational Medicine

Lung cancer: potential targets for immunotherapy

(2013) Eric Tartour et al.   Lancet Respiratory Medicine

CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions

(2012) K. Franciszkiewicz et al.   CANCER RESEARCH

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Recirculating Memory T Cells Are a Unique Subset of CD4+ T Cells with a Distinct Phenotype and Migratory Pattern

(2012) S. K. Bromley et al.   JOURNAL OF IMMUNOLOGY

Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues

(2012) K. A. Casey et al.   JOURNAL OF IMMUNOLOGY

The Molecular Signature of Tissue Resident Memory CD8 T Cells Isolated from the Brain

(2012) L. M. Wakim et al.   JOURNAL OF IMMUNOLOGY

A vaccine strategy that protects against genital herpes by establishing local memory T cells

(2012) Haina Shin et al.   NATURE

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

(2012) L. K. Mackay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression

(2011) M. C. Wolkers et al.   BLOOD

Minimal Engagement of CD103 on Cytotoxic T Lymphocytes with an E-Cadherin-Fc Molecule Triggers Lytic Granule Polarization via a Phospholipase Cγ–Dependent Pathway

(2011) Audrey Le Floc'h et al.   CANCER RESEARCH

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung

(2011) Berber Piet et al.   JOURNAL OF CLINICAL INVESTIGATION

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Dynamic T cell migration program provides resident memory within intestinal epithelium

(2010) David Masopust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral Induction of CD103 Triggers Tumor-Specific CTL Function and CCR5-Dependent T-Cell Retention

(2009) K. Franciszkiewicz et al.   CANCER RESEARCH

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

(2008) L. M. Wakim et al.   SCIENCE