Insights into the molecular basis and mechanism of heme‐triggered TLR4 signalling: The role of heme‐binding motifs in TLR4 and MD2

Heme induces inflammatory injury by directly binding to the complex of myeloid differentiation protein 2 and toll-like receptor 4

(2022) Jianjun Lin et al.   TOXICOLOGY LETTERS

Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease

(2021) Joan D. Beckman et al.   Frontiers in Immunology

Linking Labile Heme with Thrombosis

(2021) Marie-Thérèse Hopp et al.   Journal of Clinical Medicine

Revisiting the interaction of heme with hemopexin

(2021) Milena Sophie Detzel et al.   BIOLOGICAL CHEMISTRY

SARS-CoV-2 spike protein interacts with and activates TLR41

(2021) Yingchi Zhao et al.   CELL RESEARCH

Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death

(2021) Beatriz E. Bolívar et al.   JOURNAL OF IMMUNOLOGY

Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

(2021) Ping Zhang et al.   Frontiers in Immunology

Linking COVID-19 and Heme-Driven Pathophysiologies: A Combined Computational–Experimental Approach

(2021) Marie-Thérèse Hopp et al.   Biomolecules

Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ

(2021) Saori Oishi et al.   Blood Advances

Type I interferon is induced by hemolysis and drives antibody-mediated erythrophagocytosis in sickle cell disease

(2021) Yunfeng Liu et al.   BLOOD

TLR4 biased small molecule modulators

(2021) Cong Lin et al.   PHARMACOLOGY & THERAPEUTICS

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

(2021) Ines H. Kaltheuner et al.   Nature Communications

Heme stimulates platelet mitochondrial oxidant production to induce targeted granule secretion

(2021) Gowtham K. Annarapu et al.   Redox Biology

New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-κB Signaling-Mediated Inflammatory Responses in Human Monocytes

(2021) Dong Young Kang et al.   Cells

A Computational Approach for Mapping Heme Biology in the Context of Hemolytic Disorders

(2020) Farah Humayun et al.   Frontiers in Bioengineering and Biotechnology

HeMoQuest: a webserver for qualitative prediction of transient heme binding to protein motifs

(2020) Ajay Abisheck Paul George et al.   BMC BIOINFORMATICS

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2

(2020) Joshua H. Bourne et al.   HAEMATOLOGICA

Molecular insights and functional consequences of the interaction of heme with activated protein C

(2020) Diana Imhof et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme causes pain in sickle mice via toll-like receptor 4-mediated ROS- and endoplasmic reticulum stress-induced glial activation

(2020) Jianxun Lei et al.   ANTIOXIDANTS & REDOX SIGNALING

High-affinity binding and catalytic activity of His/Tyr-based sequences: Extending heme-regulatory motifs beyond CP

(2020) Benjamin Franz Syllwasschy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

(2020) John D. Belcher et al.   Frontiers in Immunology

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

(2020) Anna Ciesielska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis

(2020) Elisa B. Prestes et al.   JOURNAL OF IMMUNOLOGY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Role of Toll Like Receptor 4 in Alzheimer’s Disease

(2020) Maria Calvo-Rodriguez et al.   Frontiers in Immunology

Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice

(2020) Oluwabukola T. Gbotosho et al.   Frontiers in Immunology

The receptor for advanced glycation end products is a sensor for cell‐free heme

(2020) Olivia May et al.   FEBS Journal

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

(2019) Nicolas S. Merle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

(2019) Anub M. Thomas et al.   JOURNAL OF IMMUNOLOGY

Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells

(2019) Gerrit Müller et al.   Autophagy

LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses

(2019) Anja Pfalzgraff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structural insights into heme binding to IL-36α proinflammatory cytokine

(2019) Amelie Wißbrock et al.   Scientific Reports

Hemolysis Derived Products Toxicity and Endothelium: Model of the Second Hit

(2019) Marie Frimat et al.   Toxins

Insights into mechanism and functional consequences of heme binding to hemolysin-activating lysine acyltransferase HlyC from Escherichia coli

(2018) Sandra Peherstorfer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo

(2018) Anja Pfalzgraff et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study

(2018) Brant M. Wagener et al.   PLOS MEDICINE

Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer

(2018) Mahesh Chandra Patra et al.   Frontiers in Immunology

Oxidized hemoglobin forms contribute to NLRP3 inflammasome-driven IL-1β production upon intravascular hemolysis

(2018) Benard Bogonko Nyakundi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage

(2017) Hyunjung Min et al.   Molecular Brain

Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli

(2016) Hans Henning Brewitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Altered heme-mediated modulation of dendritic cell function in sickle cell alloimmunization

(2016) E. Godefroy et al.   HAEMATOLOGICA

The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation

(2016) Monica Molteni et al.   MEDIATORS OF INFLAMMATION

Heme: Modulator of Plasma Systems in Hemolytic Diseases

(2016) Lubka T. Roumenina et al.   TRENDS IN MOLECULAR MEDICINE

Altered heme-mediated modulation of dendritic cell function in sickle cell alloimmunization

(2016) E. Godefroy et al.   HAEMATOLOGICA

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

Role of the Chemical Environment beyond the Coordination Site: Structural Insight into FeIIIProtoporphyrin Binding to Cysteine-Based Heme-Regulatory Protein Motifs

(2015) Hans Henning Brewitz et al.   CHEMBIOCHEM

Spectroscopic studies on peptides and proteins with cysteine-containing heme regulatory motifs (HRM)

(2015) Erik Schubert et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent

(2015) Carmen M. Dickinson-Copeland et al.   PLoS One

TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts

(2014) Saghi Hamidi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

YASARA View—molecular graphics for all devices—from smartphones to workstations

(2014) Elmar Krieger et al.   BIOINFORMATICS

Heme-Binding Properties of HupD Functioning as a Substrate-Binding Protein in a Heme-Uptake ABC-Transporter System in Listeria monocytogenes

(2014) Yasunori Okamoto et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation

(2014) Qianwei Li et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Building Force Fields: An Automatic, Systematic, and Reproducible Approach

(2014) Lee-Ping Wang et al.   Journal of Physical Chemistry Letters

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

Analysis of Fe(III) Heme Binding to Cysteine-Containing Heme-Regulatory Motifs in Proteins

(2013) Toni Kühl et al.   ACS Chemical Biology

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

(2013) Carmen Noelker et al.   Scientific Reports

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Signaling Organelles of the Innate Immune System

(2012) Jonathan C. Kagan   CELL

X-ray structure of the Yersinia pestis heme transporter HmuUV

(2012) Jae-Sung Woo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

(2012) K. Schroder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HemeBIND: a novel method for heme binding residue prediction by combining structural and sequence information

(2011) Rong Liu et al.   BMC BIOINFORMATICS

Determination of Hemin-Binding Characteristics of Proteins by a Combinatorial Peptide Library Approach

(2011) Toni Kühl et al.   CHEMBIOCHEM

Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets

(2010) Matteo Piazza et al.   Innate Immunity

Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

(2010) Patricia L. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme Impairs Prostaglandin E2 and TGF-  Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

(2010) B. B. Andrade et al.   JOURNAL OF IMMUNOLOGY

Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll‐Like Receptor Agonists and Is Blocked by Hemopexin

(2010) Tian Lin et al.   JOURNAL OF INFECTIOUS DISEASES

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA