Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

Genetics and Outcome of Atypical Hemolytic Uremic Syndrome: A Nationwide French Series Comparing Children and Adults

(2013) V. Fremeaux-Bacchi et al.   Clinical Journal of the American Society of Nephrology

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

(2012) L. T. Roumenina et al.   BLOOD

Overall Neutralization of Complement Factor H by Autoantibodies in the Acute Phase of the Autoimmune Form of Atypical Hemolytic Uremic Syndrome

(2012) C. Blanc et al.   JOURNAL OF IMMUNOLOGY

Heme Interacts with C1q and Inhibits the Classical Complement Pathway

(2011) Lubka T. Roumenina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative complement pathway assessment in patients with atypical HUS

(2011) Lubka T. Roumenina et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

(2011) David Weismann et al.   NATURE

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B

(2010) J. Rayes et al.   BLOOD

Activation of complement in normal serum by hydrogen peroxide and hydrogen peroxide-related oxygen radicals produced by activated neutrophils

(2010) M. SHINGU et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pregnancy-Associated Hemolytic Uremic Syndrome Revisited in the Era of Complement Gene Mutations

(2010) F. Fakhouri et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clinical Features of Anti-Factor H Autoantibody-Associated Hemolytic Uremic Syndrome

(2010) M.-A. Dragon-Durey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dynamic control of the complement system by modulated expression of regulatory proteins

(2010) Joshua M Thurman et al.   LABORATORY INVESTIGATION

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome

(2009) L. T. Roumenina et al.   BLOOD

Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

(2009) Markus J. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury

(2009) Joshua M. Thurman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Hemolytic–Uremic Syndrome

(2009) Marina Noris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

(2008) V. Fremeaux-Bacchi et al.   BLOOD