Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease

(2021) Joan D. Beckman et al.   Frontiers in Immunology

The multifaceted role of ischemia/reperfusion in sickle cell anemia

(2020) Robert P. Hebbel et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

(2020) John D. Belcher et al.   Frontiers in Immunology

Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients

(2018) Rayra Pereira Santiago et al.   BLOOD CELLS MOLECULES AND DISEASES

Inflammation in sickle cell disease

(2018) Nicola Conran et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

(2018) Lingfeng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

(2018) John D. Belcher et al.   PLoS One

Pathophysiology of Sickle Cell Disease

(2018) Prithu Sundd et al.   Annual Review of Pathology-Mechanisms of Disease

Therapeutic strategies for sickle cell disease: towards a multi-agent approach

(2018) Marilyn J. Telen et al.   NATURE REVIEWS DRUG DISCOVERY

Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

(2017) Yi Wang et al.   Nature Communications

MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

(2016) Jibo Han et al.   BASIC RESEARCH IN CARDIOLOGY

Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell

(2016) Thassila N. Pitanga et al.   CYTOKINE

Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS-induced acute lung injury

(2016) Yali Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

(2016) Gregory M Vercellotti et al.   MOLECULAR MEDICINE

TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS

(2016) Ying Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory targets of therapy in sickle cell disease

(2016) Amma Owusu-Ansah et al.   Translational Research

MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis

(2015) Yi Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies

(2015) Bidossessi Wilfried Hounkpe et al.   Scientific Reports

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

(2015) Seiji Yamamoto et al.   Scientific Reports

Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation

(2014) H. Xu et al.   BLOOD

Cellular Adhesion and the Endothelium

(2014) Marilyn J. Telen   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a

(2014) Yanhong Wang et al.   INFLAMMATION

IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients

(2014) O. Sandanger et al.   JOURNAL OF IMMUNOLOGY

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Biomarkers of Inflammation, Growth Factor, and Coagulation Activation in Patients With Sickle Cell Disease

(2011) M. H. Qari et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Interferon-γ-induced MD-2 Protein Expression and Lipopolysaccharide (LPS) Responsiveness in Corneal Epithelial Cells Is Mediated by Janus Tyrosine Kinase-2 Activation and Direct Binding of STAT1 Protein to the MD-2 Promoter

(2011) Sanhita Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid differentiation 2 as a therapeutic target of inflammatory disorders

(2011) Sun Hong Park et al.   PHARMACOLOGY & THERAPEUTICS

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

(2010) Patricia L. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MD-2–Dependent Pulmonary Immune Responses to Inhaled Lipooligosaccharides

(2008) Suzana Hađina et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased release of sMD-2 during human endotoxemia and sepsis: A role for endothelial cells

(2008) Tim G.A.M. Wolfs et al.   MOLECULAR IMMUNOLOGY

Pulmonary Complications of Sickle Cell Disease

(2008) Mark T. Gladwin et al.   NEW ENGLAND JOURNAL OF MEDICINE