Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood

Factor H interfers with the adhesion of sickle red cells to vascular endothelium: a novel disease modulating molecule

(2019) Elisabetta Lombardi et al.   HAEMATOLOGICA

Complement activation during intravascular hemolysis: Implication for sickle cell disease and hemolytic transfusion reactions

(2019) N.S. Merle et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome

(2018) Anub Mathew Thomas et al.   Neonatology

Critical role of C5a in sickle cell disease

(2018) Gregory M. Vercellotti et al.   AMERICAN JOURNAL OF HEMATOLOGY

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

(2018) Olivia May et al.   Frontiers in Immunology

Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets

(2016) Andreas Barratt-Due et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heme: Modulator of Plasma Systems in Hemolytic Diseases

(2016) Lubka T. Roumenina et al.   TRENDS IN MOLECULAR MEDICINE

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses inPlasmodium falciparumMalaria

(2015) Aase Berg et al.   JOURNAL OF INFECTIOUS DISEASES

Excess of heme induces tissue factor-dependent activation of coagulation in mice

(2015) E. M. Sparkenbaugh et al.   HAEMATOLOGICA

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

(2014) G. Chen et al.   BLOOD

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis

(2013) A. Barratt-Due et al.   JOURNAL OF IMMUNOLOGY

Chimeric Anti-CD14 IGG2/4 Hybrid Antibodies for Therapeutic Intervention in Pig and Human Models of Inflammation

(2013) C. Lau et al.   JOURNAL OF IMMUNOLOGY

An international serum standard for application in assays to detect human complement activation products

(2013) Grethe Bergseth et al.   MOLECULAR IMMUNOLOGY

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

(2012) P. Chantrathammachart et al.   BLOOD

Advances in assay of complement function and activation

(2011) Morten Harboe et al.   ADVANCED DRUG DELIVERY REVIEWS

Complement Activation Triggers Metalloproteinases Release Inducing Cervical Remodeling and Preterm Birth in Mice

(2011) Juan M. Gonzalez et al.   AMERICAN JOURNAL OF PATHOLOGY

Complement takes its Toll: an inflammatory crosstalk between Toll-like receptors and the receptors for the complement anaphylatoxin C5a

(2011) B. Holst et al.   ANAESTHESIA

Heme Interacts with C1q and Inhibits the Classical Complement Pathway

(2011) Lubka T. Roumenina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukotriene B4 Mediates Neutrophil Migration Induced by Heme

(2011) A. P. T. Monteiro et al.   JOURNAL OF IMMUNOLOGY

Ornithodoros moubata Complement Inhibitor Is an Equally Effective C5 Inhibitor in Pigs and Humans

(2011) A. Barratt-Due et al.   JOURNAL OF IMMUNOLOGY

Hemoglobin-Induced Oxidative Stress Contributes to Matrix Metalloproteinase Activation and Blood–Brain Barrier Dysfunction in vivo

(2010) Masataka Katsu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Harmful Role of C5a on Innate Immunity in Sepsis

(2010) Peter A. Ward   Journal of Innate Immunity

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Elevated Levels of Prothrombin Fragment 1 + 2 Indicate High Risk of Thrombosis

(2007) Satoshi Ota et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS