Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

A MarR Family Transcriptional Regulator, DptR3, Activates Daptomycin Biosynthesis and Morphological Differentiation in Streptomyces roseosporus

(2015) Qinling Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome Mining ofStreptomycessp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway

(2015) Carolina Cano-Prieto et al.   CHEMBIOCHEM

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743

(2015) Michael M. Schofield et al.   ENVIRONMENTAL MICROBIOLOGY

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

Computational approaches to natural product discovery

(2015) Marnix H Medema et al.   Nature Chemical Biology

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

The EMBL-EBI bioinformatics web and programmatic tools framework

(2015) Weizhong Li et al.   NUCLEIC ACIDS RESEARCH

Structural and Biochemical Characterization ofChlamydia trachomatisHypothetical Protein CT263 Supports That Menaquinone Synthesis Occurs through the Futalosine Pathway

(2014) Michael L. Barta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lomaiviticin Biosynthesis Employs a New Strategy for Starter Unit Generation

(2014) Abraham J. Waldman et al.   ORGANIC LETTERS

Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells

(2013) Abhilash Samykutty et al.   Evidence-based Complementary and Alternative Medicine

Menaquinone Biosynthesis: Formation of Aminofutalosine Requires a Unique Radical SAM Enzyme

(2013) Nilkamal Mahanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advantages of Single-Molecule Real-Time Sequencing in High-GC Content Genomes

(2013) Seung Chul Shin et al.   PLoS One

Langkolide, a 32-Membered Macrolactone Antibiotic Produced by Streptomyces sp. Acta 3062

(2012) Soleiman E. Helaly et al.   JOURNAL OF NATURAL PRODUCTS

Diversity of P450 enzymes in the biosynthesis of natural products

(2012) Larissa M. Podust et al.   NATURAL PRODUCT REPORTS

LAL Regulators SCO0877 and SCO7173 as Pleiotropic Modulators of Phosphate Starvation Response and Actinorhodin Biosynthesis in Streptomyces coelicolor

(2012) Susana M. Guerra et al.   PLoS One

Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities

(2011) Ah Reum Han et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate

(2011) D. H. Horna et al.   JOURNAL OF BACTERIOLOGY

Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoAcarboxylase/reductase homologs in expanding polyketide diversity

(2011) Micheal C. Wilson et al.   NATURAL PRODUCT REPORTS

Unusual carbon fixation gives rise to diverse polyketide extender units

(2011) Nick Quade et al.   Nature Chemical Biology

A guide to successful bioprospecting: informed by actinobacterial systematics

(2010) Michael Goodfellow et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Assembly algorithms for next-generation sequencing data

(2010) Jason R. Miller et al.   GENOMICS

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

(2010) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Automated genome mining for natural products

(2009) Michael HT Li et al.   BMC BIOINFORMATICS

An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains

(2009) Tohru Dairi   JOURNAL OF ANTIBIOTICS

Antitumor Compounds from Marine Actinomycetes

(2009) Carlos Olano et al.   Marine Drugs

Heme and menaquinone induced electron transport in lactic acid bacteria

(2009) Rob Brooijmans et al.   Microbial Cell Factories

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

(2009) Pooja Arora et al.   Nature Chemical Biology

Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces noursei

(2008) Trygve Brautaset et al.   CHEMISTRY & BIOLOGY

Renaissance in antibacterial discovery from actinomycetes

(2008) R BALTZ   CURRENT OPINION IN PHARMACOLOGY

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

(2008) Antonio Starcevic et al.   NUCLEIC ACIDS RESEARCH

An Alternative Menaquinone Biosynthetic Pathway Operating in Microorganisms

(2008) T. Hiratsuka et al.   SCIENCE