Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoAcarboxylase/reductase homologs in expanding polyketide diversity

Divergolides A-D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis

(2011) Ling Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Characterization of 2-Octenoyl-CoA Carboxylase/Reductase UtilizingpteBfromStreptomyce avermitilis

(2011) Hye-Gyeong YOO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors

(2011) Shwan Rachid et al.   CHEMBIOCHEM

3,6,7-tri-epi-invictolide, a diastereomer of queen recognition pheromone and its analog from a marine-derived actinomycete

(2011) Seizo Sato et al.   JOURNAL OF ANTIBIOTICS

Structure and Biosynthesis of the Marine Streptomycete Ansamycin Ansalactam A and Its Distinctive Branched Chain Polyketide Extender Unit

(2011) Micheal C. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation

(2011) Shunji Takahashi et al.   Nature Chemical Biology

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

(2010) Tobias A. M. Gulder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biotechnological potential of the ethylmalonyl-CoA pathway

(2010) Birgit E. Alber   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Discovery of Salinosporamide K from the Marine Bacterium “Salinispora pacifica” by Genome Mining Gives Insight into Pathway Evolution

(2010) Alessandra S. Eustáquio et al.   CHEMBIOCHEM

Biosynthesis of Thuggacins in Myxobacteria: Comparative Cluster Analysis Reveals Basis for Natural Product Structural Diversity

(2010) Kathrin Buntin et al.   CHEMISTRY & BIOLOGY

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of 5-Chloro-5-Deoxy-d-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis

(2010) Andrew J. Kale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Fluorometabolite Production: Fluorinase Expression inSalinispora tropicaYields Fluorosalinosporamide†

(2010) Alessandra S. Eustáquio et al.   JOURNAL OF NATURAL PRODUCTS

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Tiacumicin B Biosynthetic Gene Cluster Affording Diversified Tiacumicin Analogues and Revealing a Tailoring Dihalogenase

(2010) Yi Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor

(2010) Xudong Qu et al.   Molecular BioSystems

Streptomyces scabies87-22 Contains a Coronafacic Acid-Like Biosynthetic Cluster That Contributes to Plant–Microbe Interactions

(2010) Dawn R. D. Bignell et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Reveromycins Revealed: New polyketidespiroketals from Australian marine-derived and terrestrial Streptomyces spp. A case of natural productsvs. artifacts

(2010) Leith Fremlin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of a Gene Cluster of Polyether Antibiotic Lasalocid fromStreptomyces lasaliensis

(2009) Akira MIGITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Analysis of the Indanomycin Biosynthetic Gene Cluster fromStreptomyces antibioticusNRRL 8167

(2009) Chaoxuan Li et al.   CHEMBIOCHEM

Characterization of the Tautomycetin Biosynthetic Gene Cluster fromStreptomyces griseochromogenesProvides New Insight into Dialkylmaleic Anhydride Biosynthesis#

(2009) Wenli Li et al.   JOURNAL OF NATURAL PRODUCTS

Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity

(2009) Yuan Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

(2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation

(2009) Tobias J. Erb et al.   MOLECULAR MICROBIOLOGY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

The impact of genomics on the exploitation of the myxobacterial secondary metabolome

(2009) Silke C. Wenzel et al.   NATURAL PRODUCT REPORTS

Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis

(2009) Dong-Chan Oh et al.   Nature Chemical Biology

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

(2009) T. J. Erb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

(2009) Gitanjali Yadav et al.   PLoS Computational Biology

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular Analysis of the Kirromycin Biosynthetic Gene Cluster Revealed β-Alanine as Precursor of the Pyridone Moiety

(2008) Tilmann Weber et al.   CHEMISTRY & BIOLOGY

Biosynthesis of polyketide synthase extender units

(2008) Yolande A. Chan et al.   NATURAL PRODUCT REPORTS

Evolution of polyketide synthases in bacteria

(2008) C. P. Ridley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA