期刊
JOURNAL OF BACTERIOLOGY
卷 193, 期 10, 页码 2647-2651出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00108-11
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资金
- Spanish Ministry of Science and Innovation [BFU2006-00404]
- Red Tematica de Investigacion Cooperativa de Centros de Cancer (Ministry of Health) [ISCIII-RETIC RD06/0020/0026]
- Obra Social Cajastur
- Spanish Ministerio de Ciencia e Innovacion of Spain (MICINN) [SAF2008-01845]
The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus. Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ, slgM, or both in S. lydicus led to a considerable increase in streptolydigin production.
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